Literature DB >> 2445070

Biopharmaceutical aspects of FK-506.

R Venkataramanan1, V S Warty, M A Zemaitis, A T Sanghvi, G J Burckart, H Seltman, S Todo, L Makowka, T E Starzl.   

Abstract

FK is a potent immunosuppressive agent. FK can be analyzed in biologic fluids by EIA. The oral absorption of FK is rapid but variable in dogs. After intramuscular administration, FK is slowly and continuously absorbed. FK is primarily eliminated by metabolism. Less than 1% of the administered dose is excreted in the bile or the urine. After chronic intramuscular administration FK inhibits drug metabolism. Monitoring of FK levels in plasma is essential for the proper interpretation of efficacy and toxicity studies.

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Year:  1987        PMID： 2445070      PMCID： PMC2953256     

Source DB:  PubMed          Journal:  Transplant Proc        ISSN： 0041-1345            Impact factor:   1.066


  8 in total

1.  THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. I. EVIDENCE FOR ITS HEMOPROTEIN NATURE.

Authors:  T OMURA; R SATO
Journal:  J Biol Chem       Date:  1964-07       Impact factor: 5.157

2.  The colorimetric estimation of formaldehyde by means of the Hantzsch reaction.

Authors:  T NASH
Journal:  Biochem J       Date:  1953-10       Impact factor: 3.857

3.  Determination of serum proteins by means of the biuret reaction.

Authors:  A G GORNALL; C J BARDAWILL; M M DAVID
Journal:  J Biol Chem       Date:  1949-02       Impact factor: 5.157

4.  Hepatic triphosphopyridine nucleotide-cytochrome c reductase: isolation, characterization, and kinetic studies.

Authors:  A H PHILLIPS; R G LANGDON
Journal:  J Biol Chem       Date:  1962-08       Impact factor: 5.157

5.  Role of bile and bile salts on cyclosporine absorption in dogs.

Authors:  B G Ericzon; S Todo; S Lynch; I Kam; R J Ptachcinski; G J Burckart; D H Van Thiel; T E Starzl; R Venkataramanan
Journal:  Transplant Proc       Date:  1987-02       Impact factor: 1.066

6.  Studies on the rate of reduction of hepatic microsomal cytochrome P-450 by reduced nicotinamide adenine dinucleotide phosphate: effect of drug substrates.

Authors:  P L Gigon; T E Gram; J R Gillette
Journal:  Mol Pharmacol       Date:  1969-03       Impact factor: 4.436

7.  The effects of cyclosporin A (CsA) on hepatic microsomal drug metabolism in the rat.

Authors:  J A Augustine; M A Zemaitis
Journal:  Drug Metab Dispos       Date:  1986 Jan-Feb       Impact factor: 3.922

8.  Influence of prednisolone on antipyrine and chloramphenicol disposition in rabbits.

Authors:  V K Shukla; S K Garg; V S Mathur
Journal:  Pharmacology       Date:  1984       Impact factor: 2.547
  8 in total
  16 in total

1.  FK 506--an effective immunosuppressant in achieving long-term functional islet allograft survival in diabetic rats.

Authors:  W J Tze; J Tai; S S Cheung; C Ricordi; N Murase; T E Starzl
Journal:  Transplant Proc       Date:  1992-06       Impact factor: 1.066

2.  The pharmacodynamics of pentobarbital following FK 506 therapy.

Authors:  K Habucky; R Venkataramanan; R Xiaoshan; V S Warty; J J Fung; T E Starzl
Journal:  Transplant Proc       Date:  1991-12       Impact factor: 1.066

3.  Pharmacokinetics of FK 506 in transplant patients.

Authors:  R Venkataramanan; A Jain; V S Warty; K Abu-Elmagd; M Alessiani; J Lever; A Krajak; J Flowers; S Mehta; S Zuckerman
Journal:  Transplant Proc       Date:  1991-12       Impact factor: 1.066

4.  Long-term survival of islet allografts in diabetic rats treated with FK 506.

Authors:  W J Tze; J Tai; S S Cheung; N Murase; C Ricordi; T E Starzl
Journal:  Transplant Proc       Date:  1991-12       Impact factor: 1.066

5.  Interaction between FK 506 and cyclosporine in dogs.

Authors:  Y M Wu; R Venkataramanan; M Suzuki; Y Zhu; H Abdallah; J Emeigh; G J Burckart; V S Warty; J J Fung; S Todo
Journal:  Transplant Proc       Date:  1991-12       Impact factor: 1.066

6.  Oral absorption of FK506 in rats.

Authors:  A Kagayama; S Tanimoto; J Fujisaki; A Kaibara; K Ohara; K Iwasaki; Y Hirano; T Hata
Journal:  Pharm Res       Date:  1993-10       Impact factor: 4.200

7.  A modern Cosmas and Damian: Sir Roy Calne and Thomas Starzl receive the 2012 Lasker~Debakey Clinical Medical Research Award.

Authors:  Jillian Hurst
Journal:  J Clin Invest       Date:  2012-10       Impact factor: 14.808

8.  Effects of the immunosuppressant FK506 on intracellular Ca2+ release and Ca2+ accumulation mechanisms.

Authors:  G Bultynck; P De Smet; A F Weidema; M Ver Heyen; K Maes; G Callewaert; L Missiaen; J B Parys; H De Smedt
Journal:  J Physiol       Date:  2000-06-15       Impact factor: 5.182

9.  Replicative senescence of biliary epithelial cells precedes bile duct loss in chronic liver allograft rejection: increased expression of p21(WAF1/Cip1) as a disease marker and the influence of immunosuppressive drugs.

Authors:  J G Lunz; S Contrucci; K Ruppert; N Murase; J J Fung; T E Starzl; A J Demetris
Journal:  Am J Pathol       Date:  2001-04       Impact factor: 4.307

Review 10.  Tacrolimus. A review of its pharmacology, and therapeutic potential in hepatic and renal transplantation.

Authors:  D H Peters; A Fitton; G L Plosker; D Faulds
Journal:  Drugs       Date:  1993-10       Impact factor: 9.546
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