Literature DB >> 24450639

New strategies for the treatment of ovarian cancer.

Elizabeth Robinson1, Natalie Fisher1, Vasileios Stamelos, Charles Redman2, Alan Richardson1.   

Abstract

Ovarian cancer usually responds well to chemotherapy, but once the disease becomes resistant to chemotherapy, the treatment options available are inadequate. A number of strategies are currently undergoing clinical evaluation, among which angiogenesis and PARP [poly(ADP-ribose) polymerase] inhibitors appear promising. Pre-clinical studies have identified several potential new therapeutic strategies, and we review the potential for use of BH3 (Bcl-2 homology) mimetics, autotaxin inhibitors and statins to treat ovarian cancer.

Entities:  

Mesh：

Substances：

Year:  2014        PMID： 24450639     DOI： 10.1042/BST20130203

Source DB:  PubMed          Journal:  Biochem Soc Trans        ISSN： 0300-5127            Impact factor:   5.407


  6 in total

1.  ABT-737 and pictilisib synergistically enhance pitavastatin-induced apoptosis in ovarian cancer cells.

Authors:  Elizabeth De Wolf; Christopher De Wolf; Alan Richardson
Journal:  Oncol Lett       Date:  2017-12-05       Impact factor: 2.967

Review 2.  Paclitaxel targets VEGF-mediated angiogenesis in ovarian cancer treatment.

Authors:  Bin Ai; Zhixin Bie; Shuai Zhang; Ailing Li
Journal:  Am J Cancer Res       Date:  2016-08-01       Impact factor: 6.166

3.  MCP-1/CCR-2 axis in adipocytes and cancer cell respectively facilitates ovarian cancer peritoneal metastasis.

Authors:  Chaoyang Sun; Xi Li; Ensong Guo; Na Li; Bo Zhou; Hao Lu; Jia Huang; Meng Xia; Wanying Shan; Beibei Wang; Kezhen Li; Danhui Weng; Xiaoyan Xu; Qinglei Gao; Shixuan Wang; Junbo Hu; Yiling Lu; Gordon B Mills; Gang Chen
Journal:  Oncogene       Date:  2019-11-08       Impact factor: 9.867

4.  Statin as a Combined Therapy for Advanced-Stage Ovarian Cancer: A Propensity Score Matched Analysis.

Authors:  Hong-Yu Chen; Qian Wang; Qiu-Hong Xu; Li Yan; Xue-Feng Gao; Yan-Hong Lu; Li Wang
Journal:  Biomed Res Int       Date:  2016-11-16       Impact factor: 3.411

5.  Statin use is associated with improved survival in ovarian cancer: A retrospective population-based study.

Authors:  Alexandra Couttenier; Olivia Lacroix; Evelien Vaes; Chris R Cardwell; Harlinde De Schutter; Annie Robert
Journal:  PLoS One       Date:  2017-12-19       Impact factor: 3.240

6.  Inhibition of the mevalonate pathway augments the activity of pitavastatin against ovarian cancer cells.

Authors:  Marwan Ibrahim Abdullah; Mohammed Najim Abed; Alan Richardson
Journal:  Sci Rep       Date:  2017-08-14       Impact factor: 4.379
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.