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Literature DB >> 24449392

Epigenetic epidemiology: promises for public health research.

Abstract

Epigenetic changes underlie developmental and age related biology. Promising epidemiologic research implicates epigenetics in disease risk and progression, and suggests epigenetic status depends on environmental risks as well as genetic predisposition. Epigenetics may represent a mechanistic link between environmental exposures, or genetics, and many common diseases, or may simply provide a quantitative biomarker for exposure or disease for areas of epidemiology currently lacking such measures. This great promise is balanced by issues related to study design, measurement tools, statistical methods, and biological interpretation that must be given careful consideration in an epidemiologic setting. This article describes the promises and challenges for epigenetic epidemiology, and suggests directions to advance this emerging area of molecular epidemiology.

Entities: CellLine Chemical Disease Gene Mutation Species

Keywords: DNA methylation; disease; environment; epidemiology; epigenetics

Mesh：

Substances：

Year: 2014 PMID： 24449392 PMCID： PMC4011487 DOI： 10.1002/em.21850

Source DB: PubMed Journal: Environ Mol Mutagen ISSN： 0893-6692 Impact factor: 3.216

154 in total

Review 1. The history of cancer epigenetics.

Authors: Andrew P Feinberg; Benjamin Tycko
Journal: Nat Rev Cancer Date: 2004-02 Impact factor: 60.716

2. Extraction, purification and analysis of histones.

Authors: David Shechter; Holger L Dormann; C David Allis; Sandra B Hake
Journal: Nat Protoc Date: 2007 Impact factor: 13.491

3. Folate depletion during pregnancy and lactation reduces genomic DNA methylation in murine adult offspring.

Authors: Jill A McKay; Kevin J Waltham; Elizabeth A Williams; John C Mathers
Journal: Genes Nutr Date: 2010-12-18 Impact factor: 5.523

4. Assessing the validity of blood-based gene expression profiles for the classification of schizophrenia and bipolar disorder: a preliminary report.

Authors: Ming T Tsuang; Nadine Nossova; Tom Yager; Min-Min Tsuang; Shi-Chin Guo; Kou Ge Shyu; Stephen J Glatt; C C Liew
Journal: Am J Med Genet B Neuropsychiatr Genet Date: 2005-02-05 Impact factor: 3.568

5. Aberrant DNA methylation associated with bipolar disorder identified from discordant monozygotic twins.

Authors: G Kuratomi; K Iwamoto; M Bundo; I Kusumi; N Kato; N Iwata; N Ozaki; T Kato
Journal: Mol Psychiatry Date: 2007-05-01 Impact factor: 15.992

Review 6. Epigenetics and the environment.

Authors: Jessica E Sutherland; Max Costa
Journal: Ann N Y Acad Sci Date: 2003-03 Impact factor: 5.691

7. Effects of green tea and black tea on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone bioactivation, DNA methylation, and lung tumorigenesis in A/J mice.

Authors: S T Shi; Z Y Wang; T J Smith; J Y Hong; W F Chen; C T Ho; C S Yang
Journal: Cancer Res Date: 1994-09-01 Impact factor: 12.701

8. Transgenerational epigenetic inheritance of longevity in Caenorhabditis elegans.

Authors: Eric L Greer; Travis J Maures; Duygu Ucar; Anna G Hauswirth; Elena Mancini; Jana P Lim; Bérénice A Benayoun; Yang Shi; Anne Brunet
Journal: Nature Date: 2011-10-19 Impact factor: 49.962

9. Maternal genistein alters coat color and protects Avy mouse offspring from obesity by modifying the fetal epigenome.

Authors: Dana C Dolinoy; Jennifer R Weidman; Robert A Waterland; Randy L Jirtle
Journal: Environ Health Perspect Date: 2006-04 Impact factor: 9.031

10. Uncertain inheritance transgenerational effects of environmental exposures.

Authors: Charles W Schmidt
Journal: Environ Health Perspect Date: 2013-10 Impact factor: 9.031

47 in total

1. Prenatal mercury concentration is associated with changes in DNA methylation at TCEANC2 in newborns.

Authors: Kelly M Bakulski; HwaJin Lee; Jason I Feinberg; Ellen M Wells; Shannon Brown; Julie B Herbstman; Frank R Witter; Rolf U Halden; Kathleen Caldwell; Mary Ellen Mortensen; Andrew E Jaffe; John Moye; Laura E Caulfield; Yi Pan; Lynn R Goldman; Andrew P Feinberg; M Daniele Fallin
Journal: Int J Epidemiol Date: 2015-04-22 Impact factor: 7.196

Epigenetic epidemiology: promises for public health research.

Review 1. The history of cancer epigenetics.

2. Extraction, purification and analysis of histones.

3. Folate depletion during pregnancy and lactation reduces genomic DNA methylation in murine adult offspring.

4. Assessing the validity of blood-based gene expression profiles for the classification of schizophrenia and bipolar disorder: a preliminary report.

5. Aberrant DNA methylation associated with bipolar disorder identified from discordant monozygotic twins.

Review 6. Epigenetics and the environment.

7. Effects of green tea and black tea on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone bioactivation, DNA methylation, and lung tumorigenesis in A/J mice.

8. Transgenerational epigenetic inheritance of longevity in Caenorhabditis elegans.

9. Maternal genistein alters coat color and protects Avy mouse offspring from obesity by modifying the fetal epigenome.

10. Uncertain inheritance transgenerational effects of environmental exposures.

1. Prenatal mercury concentration is associated with changes in DNA methylation at TCEANC2 in newborns.

Review 2. Early Life Exposures and Adult Cancer Risk.

3. Epigenetic Research in Neuropsychiatric Disorders: the "Tissue Issue".

4. Copper associates with differential methylation in placentae from two US birth cohorts.

5. DNA methylation of cord blood cell types: Applications for mixed cell birth studies.

6. Cord blood buffy coat DNA methylation is comparable to whole cord blood methylation.

7. Mediation by Placental DNA Methylation of the Association of Prenatal Maternal Smoking and Birth Weight.

8. Genome-Wide Epigenetic Studies in Human Disease: A Primer on -Omic Technologies.

9. Untargeted metabolomics reveals multiple metabolites influencing smoking-related DNA methylation.

Review 10. Epigenetic Biomarkers of Breast Cancer Risk: Across the Breast Cancer Prevention Continuum.