Literature DB >> 24449311

Improving the drug development process: more not less randomized trials.

Benjamin Djulbegovic1, Iztok Hozo2, John P A Ioannidis3.   

Abstract

Mesh:

Year:  2014        PMID: 24449311     DOI: 10.1001/jama.2013.283742

Source DB:  PubMed          Journal:  JAMA        ISSN: 0098-7484            Impact factor:   56.272


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  8 in total

Review 1.  Precision medicine needs randomized clinical trials.

Authors:  Everardo D Saad; Xavier Paoletti; Tomasz Burzykowski; Marc Buyse
Journal:  Nat Rev Clin Oncol       Date:  2017-02-07       Impact factor: 66.675

2.  Timing and Characteristics of Cumulative Evidence Available on Novel Therapeutic Agents Receiving Food and Drug Administration Accelerated Approval.

Authors:  Huseyin Naci; Olivier J Wouters; Radhika Gupta; John P A Ioannidis
Journal:  Milbank Q       Date:  2017-06       Impact factor: 4.911

Review 3.  Testing cardiovascular drug safety and efficacy in randomized trials.

Authors:  Garret A FitzGerald
Journal:  Circ Res       Date:  2014-03-28       Impact factor: 17.367

4.  Predicting success in regulatory approval from Phase I results.

Authors:  Laeeq Malik; Alex Mejia; Helen Parsons; Benjamin Ehler; Devalingam Mahalingam; Andrew Brenner; John Sarantopoulos; Steven Weitman
Journal:  Cancer Chemother Pharmacol       Date:  2014-09-23       Impact factor: 3.333

5.  Benchmarks for detecting 'breakthroughs' in clinical trials: empirical assessment of the probability of large treatment effects using kernel density estimation.

Authors:  Branko Miladinovic; Ambuj Kumar; Rahul Mhaskar; Benjamin Djulbegovic
Journal:  BMJ Open       Date:  2014-10-21       Impact factor: 2.692

Review 6.  When Null Hypothesis Significance Testing Is Unsuitable for Research: A Reassessment.

Authors:  Denes Szucs; John P A Ioannidis
Journal:  Front Hum Neurosci       Date:  2017-08-03       Impact factor: 3.169

Review 7.  Are adaptive randomised trials or non-randomised studies the best way to address the Ebola outbreak in west Africa?

Authors:  Simone Lanini; Alimuddin Zumla; John P A Ioannidis; Antonino Di Caro; Sanjeev Krishna; Lawrence Gostin; Enrico Girardi; Michel Pletschette; Gino Strada; Aldo Baritussio; Gina Portella; Giovanni Apolone; Silvio Cavuto; Roberto Satolli; Peter Kremsner; Francesco Vairo; Giuseppe Ippolito
Journal:  Lancet Infect Dis       Date:  2015-04-14       Impact factor: 25.071

8.  Partnering With Patients in the Development and Lifecycle of Medicines: A Call for Action.

Authors:  Anton Hoos; James Anderson; Marc Boutin; Lode Dewulf; Jan Geissler; Graeme Johnston; Angelika Joos; Marilyn Metcalf; Jeanne Regnante; Ifeanyi Sargeant; Roslyn F Schneider; Veronica Todaro; Gervais Tougas
Journal:  Ther Innov Regul Sci       Date:  2015-11       Impact factor: 1.778

  8 in total

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