| Literature DB >> 24448670 |
P-L Lam1, G-L Lu, K-M Hon, K-W Lee, C-L Ho, X Wang, J C-O Tang, K-H Lam, R S-M Wong, S H-L Kok, Z-X Bian, H Li, K K-H Lee, R Gambari, C-H Chui, W-Y Wong.
Abstract
A series of ruthenium(II) bis(2,2'-bipyridyl) complexes containing N-phenyl-substituted diazafluorenes (Ru-C1, Ru-C6, Ru-C7 and Ru-F) was synthesized and their potential antibacterial activity against methicillin resistant Staphylococcus aureus (MRSA) was investigated. The Ru-C7 complex showed significant improvement in both minimum inhibitory concentration (MIC, 6.25 μg mL(-1)) and minimum bactericidal concentration (MBC, 25 μg mL(-1)) towards MRSA when compared with those of methicillin (positive control) (MIC = 25 μg mL(-1) and MBC = 100 μg mL(-1)). The Ru-C7 complex possessed much stronger antibacterial effects than the Ru-C6 complex (MIC, 25 μg mL(-1), MBC, >100 μg mL(-1)). Both Ru-C6 and Ru-C7 complexes were also demonstrated to be biologically safe when tested on normal human skin keratinocytes.Entities:
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Year: 2014 PMID： 24448670 DOI： 10.1039/c3dt52879k
Source DB: PubMed Journal: Dalton Trans ISSN： 1477-9226 Impact factor: 4.390