| Literature DB >> 24447345 |
Maximilian J Waldner1, Markus F Neurath2.
Abstract
IL-6 signaling is of central importance for the maintenance of chronic intestinal inflammation in inflammatory bowel diseases (IBD) such as Crohn's disease and ulcerative colitis. IL-6 regulates T cell differentiation, activation and resistance against apoptosis and thereby controls the balance between pro-inflammatory T cell subsets such as Th1 or Th17 cells and immunosuppressive regulatory T cells. Furthermore, IL-6 has been implicated in the pathogenesis of colorectal cancer (CRC). In fact, IL-6 directly promotes tumor cell proliferation and survival through STAT3 activation. Due to its role in both types of diseases, IL-6 has been proposed as a missing link between inflammation and tumor development. During recent years, several therapeutics targeting IL-6 dependent pathways have been developed. Although clinical data about anti-IL-6 treatment in intestinal diseases are currently scarce, targeting this pathway might be a promising strategy in IBD and CRC.Entities:
Keywords: Colorectal cancer; Crohn's disease; Cytokines; Inflammatory bowel disease; Interleukin-6; JAK; SOCS3; STAT3; Ulcerative colitis
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Year: 2014 PMID： 24447345 DOI： 10.1016/j.smim.2013.12.003
Source DB: PubMed Journal: Semin Immunol ISSN： 1044-5323 Impact factor: 11.130