Ryudo Fujiwara1, Akihiro Yoshida2, Ken-Ichi Hirata2. 1. Department of internal medicine, Division of cardiovascular medicine, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan snowreveries119@yahoo.co.jp. 2. Department of internal medicine, Division of cardiovascular medicine, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan.