BACKGROUND: The effect of sentinel lymph node status on survival in patients with Merkel cell carcinoma (MCC) of the head and neck is uncertain. METHODS: We used the Surveillance Epidemiology and End Results (SEER) database to identify patients with MCC who underwent sentinel lymph node biopsy (SLNB). Clinicopathologic data and disease-specific survival (DSS) were compared among patients with positive and negative sentinel lymph nodes. RESULTS: We identified 721 patients with cutaneous MCC who underwent SLNB, of which 173 (24%) had head and neck MCC. The rate of sentinel lymph node positivity in patients with head and neck MCC was 23.1%. Sentinel lymph node metastasis did not significantly affect survival in head and neck MCC (p = .139). CONCLUSION: Using the SEER database, we report what we believe to be the largest head and neck MCC study to date. Our results suggest that sentinel lymph node status does not predict survival in head and neck MCC. Independent predictors of MCC-related mortality seem to be unique in the head and neck region.
BACKGROUND: The effect of sentinel lymph node status on survival in patients with Merkel cell carcinoma (MCC) of the head and neck is uncertain. METHODS: We used the Surveillance Epidemiology and End Results (SEER) database to identify patients with MCC who underwent sentinel lymph node biopsy (SLNB). Clinicopathologic data and disease-specific survival (DSS) were compared among patients with positive and negative sentinel lymph nodes. RESULTS: We identified 721 patients with cutaneous MCC who underwent SLNB, of which 173 (24%) had head and neck MCC. The rate of sentinel lymph node positivity in patients with head and neck MCC was 23.1%. Sentinel lymph node metastasis did not significantly affect survival in head and neck MCC (p = .139). CONCLUSION: Using the SEER database, we report what we believe to be the largest head and neck MCC study to date. Our results suggest that sentinel lymph node status does not predict survival in head and neck MCC. Independent predictors of MCC-related mortality seem to be unique in the head and neck region.
Authors: Yun Song; Feredun S Azari; Rebecca Tang; Adrienne B Shannon; John T Miura; Douglas L Fraker; Giorgos C Karakousis Journal: Ann Surg Oncol Date: 2020-05-13 Impact factor: 4.339
Authors: Ellen M Zwijnenburg; Satish F K Lubeek; Johanna E M Werner; Avital L Amir; Willem L J Weijs; Robert P Takes; Sjoert A H Pegge; Carla M L van Herpen; Gosse J Adema; Johannes H A M Kaanders Journal: Cancers (Basel) Date: 2021-03-31 Impact factor: 6.639
Authors: Monika Dudzisz-Sledz; Paweł Sobczuk; Katarzyna Kozak; Tomasz Switaj; Hanna Kosela-Paterczyk; Anna Malgorzata Czarnecka; Slawomir Falkowski; Paweł Rogala; Tadeusz Morysinski; Mateusz Jacek Spalek; Marcin Zdzienicki; Tomasz Goryn; Marcin Zietek; Bozena Cybulska-Stopa; Stanisław Klek; Grazyna Kaminska-Winciorek; Barbara Ziolkowska; Anna Szumera-Cieckiewicz; Piotr Rutkowski Journal: Cancers (Basel) Date: 2022-01-14 Impact factor: 6.639