Literature DB >> 24446339

miR-34a targets the inhibin beta B gene, promoting granulosa cell apoptosis in the porcine ovary.

F Tu1, Z X Pan1, Y Yao1, H L Liu1, S R Liu2, Z Xie3, Q F Li1.   

Abstract

During ovarian follicular growth and development, only a few follicles actually ovulate. Recently, it was found that follicular atresia is triggered by granulosa cell apoptosis, but the molecular mechanism of follicular atresia was not understood. Using flow cytometry, we found that miR-34a promotes granulosa cell apoptosis in pig ovarian follicles. In addition, inhibin beta B was found to be a miR-34a target gene, based on luciferase reporter assays, quantitative RT-PCR and Western blotting. Taken together, our data indicate that miR-34a plays an important role in granulosa cell apoptosis by targeting the INHBB gene in the porcine ovary.

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Year:  2014        PMID： 24446339     DOI： 10.4238/2014.January.14.6

Source DB:  PubMed          Journal:  Genet Mol Res        ISSN： 1676-5680


  14 in total

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2.  Upregulation of miR-34a by diallyl disulfide suppresses invasion and induces apoptosis in SGC-7901 cells through inhibition of the PI3K/Akt signaling pathway.

Authors:  Guojun Wang; Guanghui Liu; Yanwei Ye; Yang Fu; Xiefu Zhang
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3.  RNAi-mediated knockdown of INHBB increases apoptosis and inhibits steroidogenesis in mouse granulosa cells.

Authors:  Mohamed M'baye; Guohua Hua; Hamid Ali Khan; Liguo Yang
Journal:  J Reprod Dev       Date:  2015-06-09       Impact factor: 2.214

4.  FoxO3 increases miR-34a to cause palmitate-induced cholangiocyte lipoapoptosis.

Authors:  Sathish Kumar Natarajan; Bailey A Stringham; Ashley M Mohr; Cody J Wehrkamp; Sizhao Lu; Mary Anne Phillippi; Dee Harrison-Findik; Justin L Mott
Journal:  J Lipid Res       Date:  2017-03-01       Impact factor: 5.922

Review 5.  MicroRNAs: New Insight in Modulating Follicular Atresia: A Review.

Authors:  Tesfaye Worku; Zia Ur Rehman; Hira Sajjad Talpur; Dinesh Bhattarai; Farman Ullah; Ngabu Malobi; Tesfaye Kebede; Liguo Yang
Journal:  Int J Mol Sci       Date:  2017-02-09       Impact factor: 5.923

6.  MicroRNA Mediating Networks in Granulosa Cells Associated with Ovarian Follicular Development.

Authors:  Baoyun Zhang; Long Chen; Guangde Feng; Wei Xiang; Ke Zhang; Mingxing Chu; Pingqing Wang
Journal:  Biomed Res Int       Date:  2017-02-19       Impact factor: 3.411

Review 7.  Non-coding RNA regulation in reproduction: Their potential use as biomarkers.

Authors:  Vanesa Robles; David G Valcarce; Marta F Riesco
Journal:  Noncoding RNA Res       Date:  2019-05-03

Review 8.  MicroRNAs in ovarian function and disorders.

Authors:  Ying Li; Ying Fang; Ying Liu; Xiaokui Yang
Journal:  J Ovarian Res       Date:  2015-08-01       Impact factor: 4.234

9.  The expression pattern of microRNAs in granulosa cells of subordinate and dominant follicles during the early luteal phase of the bovine estrous cycle.

Authors:  Dessie Salilew-Wondim; Ijaz Ahmad; Samuel Gebremedhn; Sudeep Sahadevan; M D Munir Hossain; Franca Rings; Michael Hoelker; Ernst Tholen; Christiane Neuhoff; Christian Looft; Karl Schellander; Dawit Tesfaye
Journal:  PLoS One       Date:  2014-09-05       Impact factor: 3.240

10.  Characterization of the miRNA regulators of the human ovulatory cascade.

Authors:  G M Yerushalmi; M Salmon-Divon; L Ophir; Y Yung; M Baum; G Coticchio; R Fadini; M Mignini-Renzini; M Dal Canto; R Machtinger; E Maman; A Hourvitz
Journal:  Sci Rep       Date:  2018-10-23       Impact factor: 4.379
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