Shally Awasthi1, Kumar Vikram. 1. Department of Pediatrics and Translational Medicine Unit, King George's Medical University, Lucknow, 226003, India, shallya@rediffmail.com.
Abstract
OBJECTIVES: To assess the association between serum 25 hydroxy vitamin D levels and asthma and its control in Indian children. METHODS: This was a prospective case-control study conducted in tertiary care hospital. Cases of asthma and healthy age-matched controls were included, aged 1-15 y, who had not received any vitamin D supplementation in the last year and had no other co-morbidity, after obtaining written informed parental consent. 25 hydroxy vitamin D insufficiency was taken below level of ≤ 30 ng/mL. RESULTS: Fifty asthmatics and 25 age-matched controls were recruited from August 2011-July 2012. 25 hydroxy vitamin D insufficiency was associated with occurrence of asthma (OR = 13.5; 95 % CI = 4.25-42.85: p = 0.000). With decreasing level of asthma control there was increasing strength of association with 25 hydroxy vitamin D insufficiency [χ (2) for trend = 24.96 (p = 0.000)]. CONCLUSIONS: 25 hydroxy vitamin D insufficiency is associated with bronchial asthma as well as its level of control.
OBJECTIVES: To assess the association between serum 25 hydroxy vitamin D levels and asthma and its control in Indian children. METHODS: This was a prospective case-control study conducted in tertiary care hospital. Cases of asthma and healthy age-matched controls were included, aged 1-15 y, who had not received any vitamin D supplementation in the last year and had no other co-morbidity, after obtaining written informed parental consent. 25 hydroxy vitamin Dinsufficiency was taken below level of ≤ 30 ng/mL. RESULTS: Fifty asthmatics and 25 age-matched controls were recruited from August 2011-July 2012. 25 hydroxy vitamin Dinsufficiency was associated with occurrence of asthma (OR = 13.5; 95 % CI = 4.25-42.85: p = 0.000). With decreasing level of asthma control there was increasing strength of association with 25 hydroxy vitamin Dinsufficiency [χ (2) for trend = 24.96 (p = 0.000)]. CONCLUSIONS: 25 hydroxy vitamin Dinsufficiency is associated with bronchial asthma as well as its level of control.
Authors: Heike A Bischoff-Ferrari; Edward Giovannucci; Walter C Willett; Thomas Dietrich; Bess Dawson-Hughes Journal: Am J Clin Nutr Date: 2006-07 Impact factor: 7.045
Authors: S B Rosalki; A Y Foo; A Burlina; W Prellwitz; P Stieber; D Neumeier; G Klein; W A Poppe; H Bodenmüller Journal: Clin Chem Date: 1993-04 Impact factor: 8.327