AIM: We wished to evaluate any continuing adverse effects upon peak aerobic power and muscle strength associated with either HAART therapy or persistently low CD4⁺ counts in men living with HIV/AIDS. METHODS: We studied 39 HIV/AIDS patients with an average disease history of 6.1 years, and 28 normal sedentary volunteers. All subjects performed tests of peak aerobic power and isokinetic muscle force, and the HIV/AIDS group also completed the Profile of Mood States (POMS) and WHO Quality of Life questionnaires. Blood was sampled for standard measures of immune function (CD4⁺ and CD8⁺ counts) and viral load. RESULTS: Patient values were generally as in the normal subjects and appeared to be uninfluenced by the CD4+ nadir or the use of HAART therapy. However, the isokinetic muscle strength was lower in individuals with a low current CD4⁺ count. Isokinetic strength was also negatively correlated with current CD4⁺ and CD8⁺ counts. CONCLUSION: HAART therapy does not appear to have an adverse long-term effect on either aerobic power or muscle strength. Many ambulatory volunteers living with HIV/AIDS have a normal peak aerobic power. However, isokinetic strength can remain low, particularly in those with low current T-cell counts.
AIM: We wished to evaluate any continuing adverse effects upon peak aerobic power and muscle strength associated with either HAART therapy or persistently low CD4⁺ counts in men living with HIV/AIDS. METHODS: We studied 39 HIV/AIDSpatients with an average disease history of 6.1 years, and 28 normal sedentary volunteers. All subjects performed tests of peak aerobic power and isokinetic muscle force, and the HIV/AIDS group also completed the Profile of Mood States (POMS) and WHO Quality of Life questionnaires. Blood was sampled for standard measures of immune function (CD4⁺ and CD8⁺ counts) and viral load. RESULTS:Patient values were generally as in the normal subjects and appeared to be uninfluenced by the CD4+ nadir or the use of HAART therapy. However, the isokinetic muscle strength was lower in individuals with a low current CD4⁺ count. Isokinetic strength was also negatively correlated with current CD4⁺ and CD8⁺ counts. CONCLUSION: HAART therapy does not appear to have an adverse long-term effect on either aerobic power or muscle strength. Many ambulatory volunteers living with HIV/AIDS have a normal peak aerobic power. However, isokinetic strength can remain low, particularly in those with low current T-cell counts.
Authors: Meredith Greene; Kenneth Covinsky; Jacquie Astemborski; Damani A Piggott; Todd Brown; Sean Leng; Noya Galai; Shruti H Mehta; Jack Guralnik; Kushang V Patel; Gregory D Kirk Journal: AIDS Date: 2014-11-28 Impact factor: 4.177