Tzu-Yi Chuang1, Hou-Tai Chang2, Kuei-Pin Chung3, Hui-Shan Cheng4, Chung-Yang Liu5, Yen-Chun Liu6, Hsiu-Han Huang6, Ting-Chen Chou6, Bei-Ling Chang7, Meng-Rui Lee8, Chou-Jui Lin1, Shih-Wei Lee1, Chong-Jen Yu9, Po-Ren Hsueh10. 1. Department of Internal Medicine, Taoyuan General Hospital, Department of Health, Taoyuan, Taiwan. 2. Department of Critical Care Medicine, Far Eastern Memorial Hospital, Taipei, Taiwan. 3. Departments of Laboratory Medicine and Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, No. 7, Chung-Shan S. Rd., Taipei 100, Taiwan; Department of Internal Medicine, National Taiwan University Hospital Hsin-Chu Branch, National Taiwan University College of Medicine, Hsin-Chu, Taiwan. 4. Departments of Laboratory Medicine and Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, No. 7, Chung-Shan S. Rd., Taipei 100, Taiwan. 5. Department of Communications Management, Ming Chuan University, Taipei, Taiwan. 6. Center of Tuberculosis Prevention, Taoyuan General Hospital, Department of Health, Taoyuan, Taiwan. 7. Department of Laboratory Medicine, Taoyuan General Hospital, Department of Health, Taoyuan, Taiwan. 8. Department of Internal Medicine, National Taiwan University Hospital Hsin-Chu Branch, National Taiwan University College of Medicine, Hsin-Chu, Taiwan. 9. Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan. 10. Departments of Laboratory Medicine and Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, No. 7, Chung-Shan S. Rd., Taipei 100, Taiwan. Electronic address: hsporen@ntu.edu.tw.
Abstract
OBJECTIVES: The aim of this study was to delineate the association between high macrophage migration inhibitory factor (MIF) and interleukin 10 (IL-10) levels in the early phase of sepsis and rapidly fatal outcome. METHODS: One hundred and fifty-three adult subjects with the main diagnosis of severe sepsis (including septic shock) admitted directly from the emergency department of two tertiary medical centers and one regional teaching hospital between January 2009 and December 2011, were included prospectively. MIF and IL-10 levels were measured and outcomes were analyzed by Cox regression analysis according to the following outcomes: rapidly fatal outcome (RFO, death within 48 h), late fatal outcome (LFO, death between 48 h and 28 days), and survival at 28 days. RESULTS: Among the three outcome groups, IL-10 levels were significantly higher in the RFO group (p < 0.001) and no significant differences were seen between the LFO and survivor groups. After Cox regression analysis, each incremental elevation of 1000 pg/ml in both IL-10 and MIF was independently associated with RFO in patients with severe sepsis. Each incremental elevation of 1000 pg/ml in IL-10 increased the RFO risk by a factor of 1.312 (95% confidence interval 1.094-1.575; p=0.003); this was the most significant factor leading to RFO in patients with severe sepsis. CONCLUSIONS: Patients with RFO exhibited simultaneously high MIF and IL-10 levels in the early phase of severe sepsis. Incremental increases in both IL-10 and MIF levels were associated with RFO in this patient group, and of the two, IL-10 was the most significant factor linked to RFO.
OBJECTIVES: The aim of this study was to delineate the association between high macrophage migration inhibitory factor (MIF) and interleukin 10 (IL-10) levels in the early phase of sepsis and rapidly fatal outcome. METHODS: One hundred and fifty-three adult subjects with the main diagnosis of severe sepsis (including septic shock) admitted directly from the emergency department of two tertiary medical centers and one regional teaching hospital between January 2009 and December 2011, were included prospectively. MIF and IL-10 levels were measured and outcomes were analyzed by Cox regression analysis according to the following outcomes: rapidly fatal outcome (RFO, death within 48 h), late fatal outcome (LFO, death between 48 h and 28 days), and survival at 28 days. RESULTS: Among the three outcome groups, IL-10 levels were significantly higher in the RFO group (p < 0.001) and no significant differences were seen between the LFO and survivor groups. After Cox regression analysis, each incremental elevation of 1000 pg/ml in both IL-10 and MIF was independently associated with RFO in patients with severe sepsis. Each incremental elevation of 1000 pg/ml in IL-10 increased the RFO risk by a factor of 1.312 (95% confidence interval 1.094-1.575; p=0.003); this was the most significant factor leading to RFO in patients with severe sepsis. CONCLUSIONS:Patients with RFO exhibited simultaneously high MIF and IL-10 levels in the early phase of severe sepsis. Incremental increases in both IL-10 and MIF levels were associated with RFO in this patient group, and of the two, IL-10 was the most significant factor linked to RFO.
Authors: Fumi Varyani; Stephan Löser; Kara J Filbey; Yvonne Harcus; Claire Drurey; Marta Campillo Poveda; Orhan Rasid; Madeleine P J White; Danielle J Smyth; François Gerbe; Philippe Jay; Rick M Maizels Journal: Mucosal Immunol Date: 2022-03-14 Impact factor: 7.313
Authors: Su Jin Kim; Bumkyoo Choi; Kang Sup Kim; Woong Jin Bae; Sung Hoo Hong; Ji Youl Lee; Tae-Kon Hwang; Sae Woong Kim Journal: Biomed Res Int Date: 2015-02-01 Impact factor: 3.411