Chien-Han Lai1, Yu-Te Wu2. 1. Department of Psychiatry, Cheng Hsin General Hospital, Taipei City, Taiwan, ROC; Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan, ROC. Electronic address: t122336257@yahoo.com.tw. 2. Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan, ROC; Brain Research Center, National Yang-Ming University, Taipei, Taiwan, ROC.
Abstract
OBJECTIVE: This study is designed to investigate the gray matter volume (GMV) deficits in patients with first-episode medication-naïve major depressive disorder (MDD). METHODS: We enrolled 38 patients with first-episode medication-naïve MDD and 27 controls in this project. Voxel-based morphometry was used to compare GMV differences between two groups. Besides, the relationship between GMV of patients and the severity of clinical symptoms was estimated to confirm the role of GMV deficits in clinical symptoms. The correlation between total GMV and illness duration was also performed to elucidate the impacts of untreated duration on the GMV. RESULTS: We found that first-episode medication-naïve MDD patients had significant GMV deficits in bilateral superior frontal gyri, left middle frontal gyrus, left medial frontal gyrus and left insula. The GMV of patient group was negatively correlated with the severity of clinical symptoms and the illness duration. CONCLUSION: A pattern of GMV deficits in fronto-insula might represent the biomarker for first-episode medication-naïve MDD.
OBJECTIVE: This study is designed to investigate the gray matter volume (GMV) deficits in patients with first-episode medication-naïve major depressive disorder (MDD). METHODS: We enrolled 38 patients with first-episode medication-naïve MDD and 27 controls in this project. Voxel-based morphometry was used to compare GMV differences between two groups. Besides, the relationship between GMV of patients and the severity of clinical symptoms was estimated to confirm the role of GMV deficits in clinical symptoms. The correlation between total GMV and illness duration was also performed to elucidate the impacts of untreated duration on the GMV. RESULTS: We found that first-episode medication-naïve MDDpatients had significant GMV deficits in bilateral superior frontal gyri, left middle frontal gyrus, left medial frontal gyrus and left insula. The GMV of patient group was negatively correlated with the severity of clinical symptoms and the illness duration. CONCLUSION: A pattern of GMV deficits in fronto-insula might represent the biomarker for first-episode medication-naïve MDD.
Authors: Rachel Upthegrove; Paris Lalousis; Pavan Mallikarjun; Katharine Chisholm; Sian Lowri Griffiths; Mariam Iqbal; Mirabel Pelton; Renate Reniers; Alexandra Stainton; Marlene Rosen; Anne Ruef; Dominic B Dwyer; Marian Surman; Theresa Haidl; Nora Penzel; Lana Kambeitz-Llankovic; Alessandro Bertolino; Paolo Brambilla; Stefan Borgwardt; Joseph Kambeitz; Rebekka Lencer; Christos Pantelis; Stephan Ruhrmann; Frauke Schultze-Lutter; Raimo K R Salokangas; Eva Meisenzahl; Stephen J Wood; Nikolaos Koutsouleris Journal: Schizophr Bull Date: 2021-01-23 Impact factor: 9.306
Authors: Meghan Rose Donohue; Rebecca Tillman; Deanna M Barch; Joan Luby; Michael S Gaffrey Journal: Psychiatry Res Neuroimaging Date: 2020-09-17 Impact factor: 2.493
Authors: Kaiping Burrows; Jennifer L Stewart; Rayus Kuplicki; Leandra Figueroa-Hall; Philip A Spechler; Haixia Zheng; Salvador M Guinjoan; Jonathan B Savitz; T Kent Teague; Martin P Paulus Journal: Brain Behav Immun Date: 2021-01-26 Impact factor: 19.227