Xiao-Ping Wu 1 , Yan-Jun Gao 1 , Jun-Le Yang 2 , Min Xu 1 , Dong-Hai Sun 1 Show Affiliations »
Abstract
BACKGROUND: Subcortical ischemic vascular dementia (SIVD) is a subtype of dementia associated with abnormalities in the subcortical white matter regions. Recent imaging techniques can be used to detect such abnormalities in vivo. PURPOSE: To examine morphological changes of the corpus callosum in patients with SIVD by using magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI). MATERIAL AND METHODS: MRI was performed to explore changes of cerebral white matter, especially corpus callosum. Brain matter diffusivity was examined with DTI by measuring the fractional anisotropy (FA). Results of 30 patients diagnosed with SIVD and 30 healthy subjects were analyzed and compared. RESULTS: The thicknesses of the genu, the anterior third, middle, and posterior third of the body, and the splenium of the corpus callosum were smaller in SIVD patients compared to healthy controls (0.54 ± 0.08 vs. 0.68 ± 0.09 cm, P = 0.0011; 0.27 ± 0.06 vs. 0.38 ± 0.07 cm, P = 0.002; 0.28 ± 0.05 vs. 0.38 ± 0.08 cm, P = 0.009; 0.18 ± 0.04 vs. 0.26 ± 0.06 cm, P = 0.013; 0.54 ± 0.07 vs. 0.72 ± 0.09 cm, P = 0.003, respectively). The FA values of the genu and splenium of the corpus callosum in patients with SIVD were decreased compared to healthy controls (0.664 ± 0.042 vs. 0.778 ± 0.041, P < 0.001; 0.691 ± 0.038 vs. 0.786 ± 0.039, P = 0.001, respectively). CONCLUSION: Patients with SIVD exhibit corpus callosum atrophy and morphological changes, and these characteristics may be useful for diagnosis. © The Foundation Acta Radiologica 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.
BACKGROUND: Subcortical ischemic vascular dementia (SIVD) is a subtype of dementia associated with abnormalities in the subcortical white matter regions. Recent imaging techniques can be used to detect such abnormalities in vivo. PURPOSE: To examine morphological changes of the corpus callosum in patients with SIVD by using magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI). MATERIAL AND METHODS: MRI was performed to explore changes of cerebral white matter, especially corpus callosum. Brain matter diffusivity was examined with DTI by measuring the fractional anisotropy (FA). Results of 30 patients diagnosed with SIVD and 30 healthy subjects were analyzed and compared. RESULTS: The thicknesses of the genu, the anterior third, middle, and posterior third of the body, and the splenium of the corpus callosum were smaller in SIVD patients compared to healthy controls (0.54 ± 0.08 vs. 0.68 ± 0.09 cm, P = 0.0011; 0.27 ± 0.06 vs. 0.38 ± 0.07 cm, P = 0.002; 0.28 ± 0.05 vs. 0.38 ± 0.08 cm, P = 0.009; 0.18 ± 0.04 vs. 0.26 ± 0.06 cm, P = 0.013; 0.54 ± 0.07 vs. 0.72 ± 0.09 cm, P = 0.003, respectively). The FA values of the genu and splenium of the corpus callosum in patients with SIVD were decreased compared to healthy controls (0.664 ± 0.042 vs. 0.778 ± 0.041, P < 0.001; 0.691 ± 0.038 vs. 0.786 ± 0.039, P = 0.001, respectively). CONCLUSION: Patients with SIVD exhibit corpus callosum atrophy and morphological changes, and these characteristics may be useful for diagnosis. © The Foundation Acta Radiologica 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.
Entities: Disease
Species
Keywords:
Subcortical ischemic vascular dementia (SIVD); corpus callosum; diffusion tensor imaging (DTI)
Mesh： See more »
Year: 2014
PMID： 24445093 DOI： 10.1177/0284185114520863
Source DB: PubMed Journal: Acta Radiol ISSN： 0284-1851 Impact factor: 1.990