Roderick Duncan1, Christopher D Graham2, Maria Oto3, Aline Russell4, Laura McKernan5, Sue Copstick4. 1. Department of Neurology, Christchurch Hospital, Christchurch, New Zealand. 2. Department of Psychology, Institute of Psychiatry, King's College London, Guy's Hospital, London, UK. 3. Department of Neurology, Southern General Hospital, Glasgow, UK. 4. Department of Neuropsychology, Southern General Hospital, Glasgow, UK. 5. Department of Clinical Neuropsychology, Southern General Hospital, Glasgow, UK.
Abstract
BACKGROUND AND OBJECTIVES: There have been few studies of long-term outcome in psychogenic non-epileptic seizures (PNES), and none of long-term healthcare utilization. METHODS: We studied attendance with seizures, healthcare use and employment over a 6-month period from the family doctors of 260 consecutive patients with psychogenic non-epileptic seizures (PNES), 5-10 years after diagnosis. RESULTS: We obtained clinical data in 188/260 patients (72.3%), of whom 60 (31.9%) had attended primary or secondary care with seizures in the previous 6 months. Predictors of attendance with seizures included a diagnosis of epilepsy+PNES (OR 5.7, p=0.009), work status (OR 3.9, p=0.027) and social security payments (OR 6.3, p=0.003). Latency to diagnosis was not predictive. Emergency admission data were available in 187 patients, of whom 25 (13.4%) had emergency hospital attendances. Prescription data were available for 172 patients, of whom 154 had 'PNES only'. Of these, 17 (11.0%) remained on antiepileptic medication (AED). 68/172 patients (39.5%) were prescribed antidepressant (AD) drugs. We had psychiatric contact data in 185 patients, of whom 49 (26.5%) had accessed psychiatric services in the last 6 months. CONCLUSIONS: Surprisingly few of our patients had presented with seizures during the study period. Early reductions in both AED use and healthcare use were sustained long term. Although psychiatric and employment outcomes were less encouraging, some aspects of PNES outcome may be better than previously thought. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.
BACKGROUND AND OBJECTIVES: There have been few studies of long-term outcome in psychogenic non-epilepticseizures (PNES), and none of long-term healthcare utilization. METHODS: We studied attendance with seizures, healthcare use and employment over a 6-month period from the family doctors of 260 consecutive patients with psychogenic non-epilepticseizures (PNES), 5-10 years after diagnosis. RESULTS: We obtained clinical data in 188/260 patients (72.3%), of whom 60 (31.9%) had attended primary or secondary care with seizures in the previous 6 months. Predictors of attendance with seizures included a diagnosis of epilepsy+PNES (OR 5.7, p=0.009), work status (OR 3.9, p=0.027) and social security payments (OR 6.3, p=0.003). Latency to diagnosis was not predictive. Emergency admission data were available in 187 patients, of whom 25 (13.4%) had emergency hospital attendances. Prescription data were available for 172 patients, of whom 154 had 'PNES only'. Of these, 17 (11.0%) remained on antiepileptic medication (AED). 68/172 patients (39.5%) were prescribed antidepressant (AD) drugs. We had psychiatric contact data in 185 patients, of whom 49 (26.5%) had accessed psychiatric services in the last 6 months. CONCLUSIONS: Surprisingly few of our patients had presented with seizures during the study period. Early reductions in both AED use and healthcare use were sustained long term. Although psychiatric and employment outcomes were less encouraging, some aspects of PNES outcome may be better than previously thought. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.
Authors: Kousuke Kanemoto; W Curt LaFrance; Roderick Duncan; David Gigineishvili; Sung-Pa Park; Yukari Tadokoro; Hiroko Ikeda; Ravi Paul; Dong Zhou; Go Taniguchi; Mike Kerr; Tomohiro Oshima; Kazutaka Jin; Markus Reuber Journal: Epilepsia Open Date: 2017-06-23