Literature DB >> 2444446

Mu-opioid receptors modulate non-cholinergic constrictor nerves in guinea-pig airways.

N Frossard1, P J Barnes.   

Abstract

A role of opioids as inhibitors of the non-adrenergic non-cholinergic (NANC) excitatory nerves has been studied in the guinea-pig bronchi using electrical field stimulation. Morphine and DAGO gave dose-dependent inhibition of NANC contraction, which was reversed by naloxone, whereas the cholinergic nerve and substance P responses were unaffected. [Met5]enkephalin and [Leu5]enkephalin weakly inhibited NANC contraction, whereas dynorphin-(1-13) had no effect. These results suggest that opiates inhibit NANC bronchoconstriction via mu-opioid receptors.

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Year:  1987        PMID： 2444446     DOI： 10.1016/0014-2999(87)90578-4

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  18 in total

1.  Effect of inhaled morphine on the bronchial response to isocapnic hyperventilation in patients with allergic asthma.

Authors:  M Mestiri; A Lurie; N Frossard; A Lockhart; J Marsac; G Strauch; J F Dessanges
Journal:  Eur J Clin Pharmacol       Date:  1991       Impact factor: 2.953

2.  Non-adrenergic, non-cholinergic neural activation stabilizes smooth-muscle tone independently of eicosanoid factors in guinea-pig isolated airways.

Authors:  A Lindén; A Ullman; C G Löfdahl; B E Skoogh
Journal:  Br J Pharmacol       Date:  1991-10       Impact factor: 8.739

Review 3.  Potassium channels and airway function: new therapeutic prospects.

Authors:  J L Black; P J Barnes
Journal:  Thorax       Date:  1990-03       Impact factor: 9.139

4.  Opioid modulation of non-cholinergic neural bronchoconstriction in guinea-pig in vivo.

Authors:  M G Belvisi; K F Chung; D M Jackson; P J Barnes
Journal:  Br J Pharmacol       Date:  1988-10       Impact factor: 8.739

5.  Capsaicin-induced bronchoconstriction in the guinea-pig: contribution of vagal cholinergic reflexes, local axon reflexes and their modulation by BW443C81.

Authors:  P Buchan; J J Adcock
Journal:  Br J Pharmacol       Date:  1992-02       Impact factor: 8.739

6.  Modulation of non-adrenergic, non-cholinergic neural bronchoconstriction in guinea-pig airways via GABAB-receptors.

Authors:  M G Belvisi; M Ichinose; P J Barnes
Journal:  Br J Pharmacol       Date:  1989-08       Impact factor: 8.739

7.  Modulation of cholinergic neurotransmission in guinea-pig airways by opioids.

Authors:  M G Belvisi; C D Stretton; P J Barnes
Journal:  Br J Pharmacol       Date:  1990-05       Impact factor: 8.739

8.  Formoterol and salbutamol inhibit bradykinin- and histamine-induced airway microvascular leakage in guinea-pig.

Authors:  C Advenier; Y Qian; J D Koune; M Molimard; M L Candenas; E Naline
Journal:  Br J Pharmacol       Date:  1992-04       Impact factor: 8.739

9.  Differential inhibitory effects of opioids on cigarette smoke, capsaicin and electrically-induced goblet cell secretion in guinea-pig trachea.

Authors:  H P Kuo; J A Rohde; P J Barnes; D F Rogers
Journal:  Br J Pharmacol       Date:  1992-02       Impact factor: 8.739

10.  Calcium-activated potassium channels mediate prejunctional inhibition of peripheral sensory nerves.

Authors:  D Stretton; M Miura; M G Belvisi; P J Barnes
Journal:  Proc Natl Acad Sci U S A       Date:  1992-02-15       Impact factor: 11.205
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