Literature DB >> 2444443

Pinacidil increases the background potassium current in single ventricular cells.

T Iijima1, N Taira.   

Abstract

Pinacidil, a new antihypertensive agent, increased the background (inward rectifier) potassium current and abolished its negative slope, and did not change the time-dependent component of the outward (delayed outward) current in single ventricular cells isolated from the guinea-pig heart. These effects must be responsible for the negative inotropic action of this drug.

Entities:  

Mesh：

Substances：

Year:  1987        PMID： 2444443     DOI： 10.1016/0014-2999(87)90421-3

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  10 in total

Review 1.  Pinacidil. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in the treatment of hypertension.

Authors:  H A Friedel; R N Brogden
Journal:  Drugs       Date:  1990-06       Impact factor: 9.546

2.  Pinacidil activates the ATP-sensitive K+ channel in inside-out and cell-attached patch membranes of guinea-pig ventricular myocytes.

Authors:  Z Fan; K Nakayama; M Hiraoka
Journal:  Pflugers Arch       Date:  1990-01       Impact factor: 3.657

3.  Potassium channel openers act through an activation of ATP-sensitive K+ channels in guinea-pig cardiac myocytes.

Authors:  D Escande; D Thuringer; S Le Guern; J Courteix; M Laville; I Cavero
Journal:  Pflugers Arch       Date:  1989-09       Impact factor: 3.657

Review 4.  The pharmacology of ATP-sensitive K+ channels in the heart.

Authors:  D Escande
Journal:  Pflugers Arch       Date:  1989       Impact factor: 3.657

5.  BRL 34915 (cromakalim) activates ATP-sensitive K+ current in cardiac muscle.

Authors:  M C Sanguinetti; A L Scott; G J Zingaro; P K Siegl
Journal:  Proc Natl Acad Sci U S A       Date:  1988-11       Impact factor: 11.205

6.  A novel cardiac potassium channel that is active and conductive at depolarized potentials.

Authors:  D T Yue; E Marban
Journal:  Pflugers Arch       Date:  1988-12       Impact factor: 3.657

7.  Effects of pinacidil, verapamil, and heart rate on afterdepolarizations in the guinea-pig heart in vivo.

Authors:  J Xu; S Zaim; A Pelleg
Journal:  Heart Vessels       Date:  1996       Impact factor: 2.037

8.  The negative inotropic effect of nicorandil is independent of cyclic GMP changes: a comparison with pinacidil and cromakalim in canine atrial muscle.

Authors:  T Yanagisawa; H Hashimoto; N Taira
Journal:  Br J Pharmacol       Date:  1988-10       Impact factor: 8.739

9.  Interaction of potassium channel openers and blockers in canine atrial muscle.

Authors:  T Yanagisawa; H Hashimoto; N Taira
Journal:  Br J Pharmacol       Date:  1989-07       Impact factor: 8.739

10.  Cardiohemodynamic effects of cromakalim and pinacidil, potassium-channel openers, in the dog, special reference to venous return.

Authors:  K Gotanda; H Yokoyama; K Satoh; N Taira
Journal:  Cardiovasc Drugs Ther       Date:  1989-08       Impact factor: 3.727
  10 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.