Ahmad Naghibzadeh Tahami1, Narges Khanjani2, Vahid Yazdi Feyzabadi3, Masoomeh Varzandeh4, Ali-Akbar Haghdoost5. 1. Research Center for Social Determinants of Health, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran, Physiology Research Center, Kerman University of Medical Sciences, Kerman, Iran. Ahaghdoost@gmail.com. 2. Enviromental Health Research Center, School of Public Health, Kerman University of Medical Sciences, Kerman, Iran. 3. Reseach Center for Health Services Management, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran Department of Health Management and Economics, School of Public Health, Tehran University of Medical Sciences. 4. Department of Forensic Medicine, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. 5. Research Center for Modeling in Health, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran.
Abstract
BACKGROUND: Gastrointestinal cancers, including esophageal, gastric, liver and pancreatic are relatively common in Iran. Furthermore, consumption of opium and its derivatives (O&D) are considerable. This study, aimed to examine the association between consumption of O&D and the incidence of upper gastrointestinal (UGI) cancers. METHODS: In a matched case-control study in Kerman (located in southeast of Iran), 142 patients with UGI cancers and 284 healthy people (matched in terms of age, sex and residence (urban/rural)) were recruited. Variables (using O&D, smoking, alcohol use and diet) were collected using a structured questionnaire. Conditional logistic regression models were used to assess the above mentioned association. RESULTS: Opium use was associated with an increased risk of UGI cancers with an adjusted OR 4.0 (95% CI=2.2-7.0). A very strong dose-response relation was observed between consumption of O&D and the incidence of UGI cancers. (Three consumption levels-none, low and high; OR=18.7; 95% CI=5.5-63.3). This dose-response relationship was also strong even in patients with gastric cancers (OR=9.2; 95% CI=2.5-33.7). CONCLUSION: The results of this study showed that opium consumption can be a strong risk factor for UGI cancers in Iran.
BACKGROUND:Gastrointestinal cancers, including esophageal, gastric, liver and pancreatic are relatively common in Iran. Furthermore, consumption of opium and its derivatives (O&D) are considerable. This study, aimed to examine the association between consumption of O&D and the incidence of upper gastrointestinal (UGI) cancers. METHODS: In a matched case-control study in Kerman (located in southeast of Iran), 142 patients with UGI cancers and 284 healthy people (matched in terms of age, sex and residence (urban/rural)) were recruited. Variables (using O&D, smoking, alcohol use and diet) were collected using a structured questionnaire. Conditional logistic regression models were used to assess the above mentioned association. RESULTS: Opium use was associated with an increased risk of UGI cancers with an adjusted OR 4.0 (95% CI=2.2-7.0). A very strong dose-response relation was observed between consumption of O&D and the incidence of UGI cancers. (Three consumption levels-none, low and high; OR=18.7; 95% CI=5.5-63.3). This dose-response relationship was also strong even in patients with gastric cancers (OR=9.2; 95% CI=2.5-33.7). CONCLUSION: The results of this study showed that opium consumption can be a strong risk factor for UGI cancers in Iran.
Authors: Atieh Rahmati; Ramin Shakeri; Hooman Khademi; Hossein Poutschi; Akram Pourshams; Arash Etemadi; Masoud Khoshnia; Amir Ali Sohrabpour; Ali Aliasgari; Elham Jafari; Farhad Islami; Shahryar Semnani; Abdolsamad Gharravi; Christian C Abnet; Paul D P Pharoah; Paul Brennan; Paolo Boffetta; Sanford M Dawsey; Reza Malekzadeh; Farin Kamangar Journal: Thorax Date: 2016-11-24 Impact factor: 9.139
Authors: Ahmad Naghibzadeh-Tahami; Vahid Yazdi Feyzabadi; Narges Khanjani; Ahad Ashrafi-Asgarabad; Hosniyeh Alizaeh; Vahid Reza Borhaninejad; Mohammad Moradi-Joo; Masoud Zeinali; Mohammad Javad Zahedi; Mahmoud Aghaee-Afshar; Ali Akbar Haghdoost Journal: Iran J Public Health Date: 2016-10 Impact factor: 1.429