Aladdin J Mohammad1, Jan-Åke Nilsson1, Lennart T H Jacobsson2, Peter A Merkel3, Carl Turesson1. 1. Department of Clinical Sciences, Section of Rheumatology, Lund University, Lund and Malmö, Sweden Department of Rheumatology, Skåne University Hospital, Lund and Malmö, Sweden. 2. Department of Clinical Sciences, Section of Rheumatology, Lund University, Lund and Malmö, Sweden Department of Inflammation Research and Rheumatology, The Sahlgrenska Academy at Gothenburg University, Gothenburg, Sweden. 3. Division of Rheumatology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Abstract
OBJECTIVES: To study the epidemiology and mortality in patients with biopsy-proven giant cell arteritis (GCA) in southern Sweden. METHODS: The study area was the County of Skåne. Patients with a positive temporal artery biopsy between 1997 and 2010 were identified using a regional register and a structured review of all histopathology reports. Standardised mortality ratios (SMR) were calculated using data for the Swedish population as the reference. RESULTS: There were 840 patients with biopsy-proven GCA (626 women). The annual incidence rate per 100,000 inhabitants aged ≥50 years was 14.1 (95% CI 13.1 to 15.0); 7.7 (6.7 to 8.7) for men and 19.6 (18.1 to 21.1) for women, without seasonal variations. The incidence increased with age, with estimates of 2.0, 11.8, and 31.3 per 100,000 in the age groups 50-60, 61-70, 71-80 years, respectively (p<0.001). The age-standardised and sex-standardised incidence rate decreased from 15.9/100,000 in 1997-2001 to 13.3/100,000 in 2007-2010 (p=0.026). Two hundred and seventy-nine patients (207 women) died during the observation period. Mortality was significantly increased over the first 2 years after GCA diagnosis (SMR 1.52 (95% CI 1.20 to 1.85)), but not with longer follow-up. The estimated excess mortality was greater in women and in patients aged ≤70 years at diagnosis. CONCLUSIONS: In this large population-based study of biopsy-proven GCA from southern Sweden, the incidence of GCA may have decreased over time. Short-term mortality was increased, in particular among those diagnosed at ≤70 years of age, but long-term survival was not impaired. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.
OBJECTIVES: To study the epidemiology and mortality in patients with biopsy-proven giant cell arteritis (GCA) in southern Sweden. METHODS: The study area was the County of Skåne. Patients with a positive temporal artery biopsy between 1997 and 2010 were identified using a regional register and a structured review of all histopathology reports. Standardised mortality ratios (SMR) were calculated using data for the Swedish population as the reference. RESULTS: There were 840 patients with biopsy-proven GCA (626 women). The annual incidence rate per 100,000 inhabitants aged ≥50 years was 14.1 (95% CI 13.1 to 15.0); 7.7 (6.7 to 8.7) for men and 19.6 (18.1 to 21.1) for women, without seasonal variations. The incidence increased with age, with estimates of 2.0, 11.8, and 31.3 per 100,000 in the age groups 50-60, 61-70, 71-80 years, respectively (p<0.001). The age-standardised and sex-standardised incidence rate decreased from 15.9/100,000 in 1997-2001 to 13.3/100,000 in 2007-2010 (p=0.026). Two hundred and seventy-nine patients (207 women) died during the observation period. Mortality was significantly increased over the first 2 years after GCA diagnosis (SMR 1.52 (95% CI 1.20 to 1.85)), but not with longer follow-up. The estimated excess mortality was greater in women and in patients aged ≤70 years at diagnosis. CONCLUSIONS: In this large population-based study of biopsy-proven GCA from southern Sweden, the incidence of GCA may have decreased over time. Short-term mortality was increased, in particular among those diagnosed at ≤70 years of age, but long-term survival was not impaired. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.
Entities:
Keywords:
Epidemiology; Giant Cell Arteritis; Outcomes research
Authors: Edsel B Ing; Dan Ni Wang; Abirami Kirubarajan; Etienne Benard-Seguin; Jingyi Ma; James P Farmer; Michel J Belliveau; Galina Sholohov; Nurhan Torun Journal: Neuroophthalmology Date: 2018-06-19