New nitrogenous bisabolene-type sesquiterpenes from a formosan sponge Axinyssa sp.

Chemical investigation of a Formosan sponge Axinyssa sp. has led to the isolation of five nitrogenous bisabolene-type sesquiterpenes 1-5, including two new compounds axinysalines A (1) and B (2). The structures of new compounds were elucidated by analysis of high resolution (HR)-MS and two dimensional (2D)-NMR spectra and comparison of its NMR data with those of known analogues. Compound 1 exhibited moderate to weak cytotoxicity against Molt 4 and K562 cancer cell lines.