| Literature DB >> 24440778 |
Yann Chevolot1, Emmanuelle Laurenceau2, Magali Phaner-Goutorbe2, Virginie Monnier2, Eliane Souteyrand2, Albert Meyer3, Thomas Géhin2, Jean-Jacques Vasseur3, François Morvan4.
Abstract
The present review concerns the recent advances in DNA directed immobilization (DDI) based glycocluster array. The impact of glycan immobilization on subsequent interactions with protein is discussed and the consequent pros and cons of DDI-based glycocluster array are reviewed. Finally, application in the discovery of anti-pathogen molecules is illustrated by screening for galactose or fucose glycoclusters targeting two Pseudomonas aeruginosa virulence factors (PA-IL and PA-IIL).Entities:
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Year: 2014 PMID: 24440778 DOI: 10.1016/j.cbpa.2013.12.009
Source DB: PubMed Journal: Curr Opin Chem Biol ISSN: 1367-5931 Impact factor: 8.822