Literature DB >> 24440371

Acidified nitrite: a host defence against colonization with C. difficile spores?

R Cunningham1, E Mustoe2, L Spiller2, S Lewis3, N Benjamin4.   

Abstract

Proton pump inhibitor (PPI) use increases the risk of Clostridium difficile infection (CDI) despite C. difficile spores being acid resistant. Swallowed saliva contains nitrite which reacts with gastric acid, producing bactericidal nitrogen oxides. With 5mM nitrite at pH 2 (reflecting normal gastric conditions) all C. difficile spores were killed within 15 min. No reduction in count was seen with the same nitrite concentration at pH 5, representing gastric conditions in patients taking PPIs, even after 60 min. Reduced gastric acidification of salivary nitrite may explain the increased risk of CDI in patients taking PPIs.
Copyright © 2013 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Acidified nitrite; Clostridium difficile infection; Proton pump inhibitor; Spore

Mesh：

Substances：

Year:  2013        PMID： 24440371     DOI： 10.1016/j.jhin.2013.12.003

Source DB:  PubMed          Journal:  J Hosp Infect        ISSN： 0195-6701            Impact factor:   3.926


  6 in total

1.  Action of nitroheterocyclic drugs against Clostridium difficile.

Authors:  Manish Kumar; Sudip Adhikari; Julian G Hurdle
Journal:  Int J Antimicrob Agents       Date:  2014-07-25       Impact factor: 5.283

Review 2.  Dietary intake and bio-activation of nitrite and nitrate in newborn infants.

Authors:  Jesica A Jones; Andrew O Hopper; Gordon G Power; Arlin B Blood
Journal:  Pediatr Res       Date:  2014-10-14       Impact factor: 3.756

Review 3.  Reactive nitrogen species in host-bacterial interactions.

Authors:  Ferric C Fang; Andrés Vázquez-Torres
Journal:  Curr Opin Immunol       Date:  2019-06-12       Impact factor: 7.486

4.  Sodium nitrite blocks the activity of aminoglycosides against Pseudomonas aeruginosa biofilms.

Authors:  Anna C Zemke; Mark T Gladwin; Jennifer M Bomberger
Journal:  Antimicrob Agents Chemother       Date:  2015-03-23       Impact factor: 5.191

5.  Hydrolysis and volatile fatty acids accumulation of waste activated sludge enhanced by the combined use of nitrite and alkaline pH.

Authors:  Cheng Huang; Congcong Liu; Xiuyun Sun; Yinglu Sun; Rui Li; Jiansheng Li; Jinyou Shen; Weiqing Han; Xiaodong Liu; Lianjun Wang
Journal:  Environ Sci Pollut Res Int       Date:  2015-07-24       Impact factor: 4.223

6.  Nitrite modulates bacterial antibiotic susceptibility and biofilm formation in association with airway epithelial cells.

Authors:  Anna C Zemke; Sruti Shiva; Jane L Burns; Samuel M Moskowitz; Joseph M Pilewski; Mark T Gladwin; Jennifer M Bomberger
Journal:  Free Radic Biol Med       Date:  2014-09-16       Impact factor: 7.376
  6 in total

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