Mariam El-Zein1, Marie-Elise Parent2, Jack Siemiatycki3, Marie-Claude Rousseau4. 1. INRS-Institut Armand-Frappier, Université du Québec, Laval, Quebec, Canada. 2. INRS-Institut Armand-Frappier, Université du Québec, Laval, Quebec, Canada; Department of Social and Preventive Medicine, University of Montreal, Montreal, Quebec, Canada; University of Montreal Hospital Research Centre (CRCHUM), Montreal, Quebec, Canada. 3. Department of Social and Preventive Medicine, University of Montreal, Montreal, Quebec, Canada; University of Montreal Hospital Research Centre (CRCHUM), Montreal, Quebec, Canada. 4. INRS-Institut Armand-Frappier, Université du Québec, Laval, Quebec, Canada; Department of Social and Preventive Medicine, University of Montreal, Montreal, Quebec, Canada; University of Montreal Hospital Research Centre (CRCHUM), Montreal, Quebec, Canada. Electronic address: marie-claude.rousseau@iaf.inrs.ca.
Abstract
BACKGROUND: The exact nature and direction of the association between a history of allergic diseases and lung cancer risk remain controversial. OBJECTIVE: To examine the association between self-reported history of allergic diseases and lung cancer using data from a population-based case-control study conducted in the Montreal metropolitan area (1996-2002). METHODS: The study is based on interview data collected from 1,169 incident lung cancer cases and 1,486 controls. Separate logistic regression models were used to estimate the relative risk of lung cancer, using odds ratios (ORs) and 95% confidence intervals (CIs), in subjects with vs without asthma, eczema, or hay fever after adjustment for several sociodemographic and lifestyle factors, including smoking. RESULTS: For asthma, the OR was 0.90 (95% CI 0.65-1.24), which decreased to 0.76 (95% CI 0.54-1.08) for subjects whose onset was more than 2 years before lung cancer diagnosis or interview and then to 0.64 (95% CI 0.44-0.93) when restricted to subjects who reported using medication for their asthma. For eczema, the point estimate was 0.73 (95% CI 0.48-1.12), which decreased to 0.63 (95% CI 0.38-1.07) when considering eczema only in those who reported medication use. Hay fever showed the strongest inverse association with lung cancer (OR 0.37, 95% CI 0.24-0.59). CONCLUSION: All 3 allergic diseases examined were inversely associated with lung cancer, although the strength of the protective effect varied. History of allergic diseases seems to have a protective role in lung cancer incidence, after consideration of potential confounders, including lifetime smoking history.
BACKGROUND: The exact nature and direction of the association between a history of allergic diseases and lung cancer risk remain controversial. OBJECTIVE: To examine the association between self-reported history of allergic diseases and lung cancer using data from a population-based case-control study conducted in the Montreal metropolitan area (1996-2002). METHODS: The study is based on interview data collected from 1,169 incident lung cancer cases and 1,486 controls. Separate logistic regression models were used to estimate the relative risk of lung cancer, using odds ratios (ORs) and 95% confidence intervals (CIs), in subjects with vs without asthma, eczema, or hay fever after adjustment for several sociodemographic and lifestyle factors, including smoking. RESULTS: For asthma, the OR was 0.90 (95% CI 0.65-1.24), which decreased to 0.76 (95% CI 0.54-1.08) for subjects whose onset was more than 2 years before lung cancer diagnosis or interview and then to 0.64 (95% CI 0.44-0.93) when restricted to subjects who reported using medication for their asthma. For eczema, the point estimate was 0.73 (95% CI 0.48-1.12), which decreased to 0.63 (95% CI 0.38-1.07) when considering eczema only in those who reported medication use. Hay fever showed the strongest inverse association with lung cancer (OR 0.37, 95% CI 0.24-0.59). CONCLUSION: All 3 allergic diseases examined were inversely associated with lung cancer, although the strength of the protective effect varied. History of allergic diseases seems to have a protective role in lung cancer incidence, after consideration of potential confounders, including lifetime smoking history.
Authors: Amanda B Muir; Kelly A Whelan; Michael K Dougherty; Bailey Aaron; Brianna Navarre; Seema S Aceves; Evan S Dellon; Elizabeth T Jensen Journal: Clin Exp Allergy Date: 2019-12-20 Impact factor: 5.018
Authors: Ranya Guennoun; Jennet Hojanazarova; Kathryn E Trerice; Marjan Azin; Matthew T McGoldrick; Erik B Schiferle; Michael P Stover; Shadmehr Demehri Journal: Cancers (Basel) Date: 2022-04-27 Impact factor: 6.575