Peter Feys1, Bo Bibby2, Anders Romberg3, Carme Santoyo4, Benoit Gebara5, Benoit Maertens de Noordhout6, Kathy Knuts7, Francois Bethoux8, Anders Skjerbæk9, Ellen Jensen9, Ilse Baert10, Claude Vaney11, Vincent de Groot12, Ulrik Dalgas13. 1. University of Hasselt, REVAL/BIOMED, Belgium. Electronic address: Peter.Feys@uhasselt.be. 2. University of Aarhus, Department of Biostatistics, Denmark. 3. Masku Neurological Rehabilitation Center, Finland. 4. Neurorehabilitation Unit, CEMCat, Barcelona, Spain. 5. National MS Center Melsbroek, Belgium. 6. Center Neurologique et de Réadaptation Fonctionelle, Fraiture, Belgium. 7. Rehabilitation and MS Center Overpelt, Belgium. 8. MS Mellen Center, Cleveland, United States. 9. MS hospitals, Ry, Denmark; MS hospitals, Haslev, Denmark. 10. University of Hasselt, REVAL/BIOMED, Belgium. 11. Berner Klinik Montana, Switzerland. 12. Vrije Universiteit, Amsterdam, The Netherlands. 13. Aarhus University, Department of Sport Sciences, Denmark.
Abstract
OBJECTIVE: To compare within-day variability of short (10 m walking test at usual and fastest speed; 10MWT) and long (2 and 6-minute walking test; 2MWT/6MWT) tests in persons with multiple sclerosis. DESIGN: Observational study. SETTING: MS rehabilitation and research centers in Europe and US within RIMS (European network for best practice and research in MS rehabilitation). SUBJECTS: Ambulatory persons with MS (Expanded Disability Status Scale 0-6.5). INTERVENTION: Subjects of different centers performed walking tests at 3 time points during a single day. MAIN MEASURES: 10MWT, 2MWT and 6MWT at fastest speed and 10MWT at usual speed. Ninety-five percent limits of agreement were computed using a random effects model with individual pwMS as random effect. Following this model, retest scores are with 95% certainty within these limits of baseline scores. RESULTS: In 102 subjects, within-day variability was constant in absolute units for the 10MWT, 2MWT and 6MWT at fastest speed (+/-0.26, 0.16 and 0.15m/s respectively, corresponding to +/-19.2m and +/-54 m for the 2MWT and 6MWT) independent on the severity of ambulatory dysfunction. This implies a greater relative variability with increasing disability level, often above 20% depending on the applied test. The relative within-day variability of the 10MWT at usual speed was +/-31% independent of ambulatory function. CONCLUSIONS: Absolute values of within-day variability on walking tests at fastest speed were independent of disability level and greater with short compared to long walking tests. Relative within-day variability remained overall constant when measured at usual speed. Crown
OBJECTIVE: To compare within-day variability of short (10 m walking test at usual and fastest speed; 10MWT) and long (2 and 6-minute walking test; 2MWT/6MWT) tests in persons with multiple sclerosis. DESIGN: Observational study. SETTING: MS rehabilitation and research centers in Europe and US within RIMS (European network for best practice and research in MS rehabilitation). SUBJECTS: Ambulatory persons with MS (Expanded Disability Status Scale 0-6.5). INTERVENTION: Subjects of different centers performed walking tests at 3 time points during a single day. MAIN MEASURES: 10MWT, 2MWT and 6MWT at fastest speed and 10MWT at usual speed. Ninety-five percent limits of agreement were computed using a random effects model with individual pwMS as random effect. Following this model, retest scores are with 95% certainty within these limits of baseline scores. RESULTS: In 102 subjects, within-day variability was constant in absolute units for the 10MWT, 2MWT and 6MWT at fastest speed (+/-0.26, 0.16 and 0.15m/s respectively, corresponding to +/-19.2m and +/-54 m for the 2MWT and 6MWT) independent on the severity of ambulatory dysfunction. This implies a greater relative variability with increasing disability level, often above 20% depending on the applied test. The relative within-day variability of the 10MWT at usual speed was +/-31% independent of ambulatory function. CONCLUSIONS: Absolute values of within-day variability on walking tests at fastest speed were independent of disability level and greater with short compared to long walking tests. Relative within-day variability remained overall constant when measured at usual speed. Crown
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