Literature DB >> 24438742

New molecular medicine-based scar management strategies.

Anna I Arno1, Gerd G Gauglitz2, Juan P Barret3, Marc G Jeschke4.   

Abstract

Keloids and hypertrophic scars are prevalent disabling conditions with still suboptimal treatments. Basic science and molecular-based medicine research have contributed to unravel new bench-to-bedside scar therapies and to dissect the complex signalling pathways involved. Peptides such as the transforming growth factor beta (TGF-β) superfamily, with Smads, Ski, SnoN, Fussels, endoglin, DS-Sily, Cav-1p, AZX100, thymosin-β4 and other related molecules may emerge as targets to prevent and treat keloids and hypertrophic scars. The aim of this review is to describe the basic complexity of these new molecular scar management strategies and point out new fibrosis research lines.
Copyright © 2013 Elsevier Ltd and ISBI. All rights reserved.

Entities:  

Keywords:  Endoglin; FAP-alpha/DPPIV; Fussels; Keloid; Rapamycin; Review; Scar; Ski; SnoN; TGF-β

Mesh：

Year:  2014        PMID： 24438742      PMCID： PMC4008699          DOI： 10.1016/j.burns.2013.11.010

Source DB:  PubMed          Journal:  Burns        ISSN： 0305-4179            Impact factor:   2.744


  131 in total

Review 1.  The transforming growth factor-betas: structure, signaling, and roles in nervous system development and functions.

Authors:  M Böttner; K Krieglstein; K Unsicker
Journal:  J Neurochem       Date:  2000-12       Impact factor: 5.372

2.  Small leucine-rich proteoglycans, decorin and fibromodulin, are reduced in postburn hypertrophic scar.

Authors:  Dariush Honardoust; Mathew Varkey; Keijiro Hori; Jie Ding; Heather A Shankowsky; Edward E Tredget
Journal:  Wound Repair Regen       Date:  2011-04-21       Impact factor: 3.617

3.  Role of caveolin-1 in the pathogenesis of tissue fibrosis by keloid-derived fibroblasts in vitro.

Authors:  G-Y Zhang; Q Yu; T Cheng; T Liao; C-L Nie; A-Y Wang; X Zheng; X-G Xie; A E Albers; W-Y Gao
Journal:  Br J Dermatol       Date:  2011-02-03       Impact factor: 9.302

4.  Effect of tamoxifen on transforming growth factor beta1 production by keloid and fetal fibroblasts.

Authors:  A A Mikulec; M M Hanasono; J Lum; J M Kadleck; M Kita; R J Koch
Journal:  Arch Facial Plast Surg       Date:  2001 Apr-Jun

Review 5.  Endocytic regulation of TGF-beta signaling.

Authors:  Ye-Guang Chen
Journal:  Cell Res       Date:  2009-01       Impact factor: 25.617

6.  Differential expression of cyclooxygenases in hypertrophic scar and keloid tissues.

Authors:  Luigi Rossiello; Francesco D'Andrea; Roberto Grella; Giuseppe Signoriello; Ciro Abbondanza; Caterina De Rosa; Mariaevelina Prudente; Marianna Morlando; Raffaele Rossiello
Journal:  Wound Repair Regen       Date:  2009 Sep-Oct       Impact factor: 3.617

7.  c-Ski, Smurf2, and Arkadia as regulators of TGF-beta signaling: new targets for managing myofibroblast function and cardiac fibrosis.

Authors:  Ryan H Cunnington; Mansoreh Nazari; Ian M C Dixon
Journal:  Can J Physiol Pharmacol       Date:  2009-10       Impact factor: 2.273

Review 8.  Antioxidative flavonoid quercetin: implication of its intestinal absorption and metabolism.

Authors:  Kaeko Murota; Junji Terao
Journal:  Arch Biochem Biophys       Date:  2003-09-01       Impact factor: 4.013

Review 9.  Mannose 6-phosphate receptor targeting and its applications in human diseases.

Authors:  M Gary-Bobo; P Nirdé; A Jeanjean; A Morère; M Garcia
Journal:  Curr Med Chem       Date:  2007       Impact factor: 4.530

10.  [The expression of fibrillin 1 in pathologic scars and its significance].

Authors:  Fang-Fei Nie; Qi Wang; Ze-Lian Qin
Journal:  Zhonghua Zheng Xing Wai Ke Za Zhi       Date:  2008-09
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  10 in total

Review 1.  Novel pharmacotherapy for burn wounds: what are the advancements.

Authors:  Michael R Hamblin
Journal:  Expert Opin Pharmacother       Date:  2018-12-05       Impact factor: 3.889

2.  Structural Basis for the Interaction of a Human Small Heat Shock Protein with the 14-3-3 Universal Signaling Regulator.

Authors:  Nikolai N Sluchanko; Steven Beelen; Alexandra A Kulikova; Stephen D Weeks; Alfred A Antson; Nikolai B Gusev; Sergei V Strelkov
Journal:  Structure       Date:  2017-01-12       Impact factor: 5.006

Review 3.  Up-to-date approach to manage keloids and hypertrophic scars: a useful guide.

Authors:  Anna I Arno; Gerd G Gauglitz; Juan P Barret; Marc G Jeschke
Journal:  Burns       Date:  2014-04-24       Impact factor: 2.744

Review 4.  The Ubiquitin Proteasome System and Skin Fibrosis.

Authors:  Wanlu Shen; Zhigang Zhang; Jiaqing Ma; Di Lu; Lechun Lyu
Journal:  Mol Diagn Ther       Date:  2021-01-12       Impact factor: 4.074

5.  Lower energy radial shock wave therapy improves characteristics of hypertrophic scar in a rabbit ear model.

Authors:  Jing-Chun Zhao; Bo-Ru Zhang; Kai Shi; Jian Wang; Qing-Hua Yu; Jia-Ao Yu
Journal:  Exp Ther Med       Date:  2017-11-06       Impact factor: 2.447

6.  Using Amniotic Membrane as a Novel Method to Reduce Post-burn Hypertrophic Scar Formation: A Prospective Follow-up Study.

Authors:  Ali Akbar Mohammadi; Shima Eskandari; Hamed Ghoddusi Johari; Ata'ollah Rajabnejad
Journal:  J Cutan Aesthet Surg       Date:  2017 Jan-Mar

7.  Coordinate activities of BRD4 and CDK9 in the transcriptional elongation complex are required for TGFβ-induced Nox4 expression and myofibroblast transdifferentiation.

Authors:  Talha Ijaz; Mohammad Jamaluddin; Yingxin Zhao; Yueqing Zhang; Jayson Jay; Celeste C Finnerty; David N Herndon; Ronald G Tilton; Allan R Brasier
Journal:  Cell Death Dis       Date:  2017-02-09       Impact factor: 8.469

Review 8.  Lasers and ancillary treatments for scar management Part 2: Keloid, hypertrophic, pigmented and acne scars.

Authors:  Rory Boyd McGoldrick; Evgenia Theodorakopoulou; Ernest Anthony Azzopardi; Maxwell Murison
Journal:  Scars Burn Heal       Date:  2017-03-14

Review 9.  Remarkable efficiency of surgical shave excision of keloids followed by intralesional injection of Bleomycin. A retrospective study of 314 cases.

Authors:  Olivier Vanhooteghem
Journal:  Dermatol Ther       Date:  2022-03-13       Impact factor: 3.858

Review 10.  The Emerging Therapeutic Targets for Scar Management: Genetic and Epigenetic Landscapes.

Authors:  Sara Amjadian; Sharif Moradi; Parvaneh Mohammadi
Journal:  Skin Pharmacol Physiol       Date:  2022-06-13       Impact factor: 3.014
  10 in total

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