Literature DB >> 24437554

A new strategy to construct acyclic nucleosides via Ag(I)-catalyzed addition of pronucleophiles to 9-allenyl-9H-purines.

Tao Wei1, Ming-Sheng Xie, Gui-Rong Qu, Hong-Ying Niu, Hai-Ming Guo.   

Abstract

A new strategy to construct acyclic nucleosides with diverse side chains was developed. With Ag(I) salts as catalysts, the hydrocarboxylation, hydroamination, and hydrocarbonation reactions proceeded well, affording acyclic nucleosides in good yields (41 examples, 60-98% yields). Meanwhile, these reactions exhibited high chemoselectivities and E-selectivities.

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Year:  2014        PMID: 24437554     DOI: 10.1021/ol4036566

Source DB:  PubMed          Journal:  Org Lett        ISSN: 1523-7052            Impact factor:   6.005


  2 in total

1.  Expedient synthesis and biological evaluation of alkenyl acyclic nucleoside phosphonate prodrugs.

Authors:  Elisa Pileggi; Michaela Serpi; Graciela Andrei; Dominique Schols; Robert Snoeck; Fabrizio Pertusati
Journal:  Bioorg Med Chem       Date:  2018-05-23       Impact factor: 3.641

2.  Synthesis and Biological Evaluation of Novel Hybrid Molecules Containing Purine, Coumarin and Isoxazoline or Isoxazole Moieties.

Authors:  Michael G Kallitsakis; Angelo Carotti; Marco Catto; Aikaterini Peperidou; Dimitra J Hadjipavlou-Litina; Konstantinos E Litinas
Journal:  Open Med Chem J       Date:  2017-11-30
  2 in total

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