Moussab Damlaj1, Ramila Amre, Phil Wong, Jonathan How. 1. Royal Victoria Hospital, Division of Hematology, 687 des pins, C6.82, Montreal, Quebec, Canada H3A 1A1; jonathan.how@mcgill.ca.
Abstract
OBJECTIVES: To examine laser microdissection and mass spectrometry (LMD-MS), which has emerged as a new tool to aid in typing amyloid proteins. RESULTS: ALECT-2 is a potential cause of hepatic amyloidosis best detected by LMD-MS. METHODS: One of the more recently reported proteins is ALECT-2 (leukocyte cell-derived chemotaxin 2) amyloid, found in renal specimens of Hispanic patients. Here we report the first case of hepatic ALECT-2 amyloidosis diagnosed by LMD-MS from a liver biopsy specimen of a 52-year-old Hispanic man and causing portal hypertension with recurrent esophageal variceal bleeding. CONCLUSIONS: ALECT-2 can cause amyloidosis in organs other than the kidneys. It should be strongly considered in Hispanic patients and in those with a globular pattern of amyloid deposition. The incidence of ALECT-2 amyloidosis is likely underreported.
OBJECTIVES: To examine laser microdissection and mass spectrometry (LMD-MS), which has emerged as a new tool to aid in typing amyloid proteins. RESULTS: ALECT-2 is a potential cause of hepatic amyloidosis best detected by LMD-MS. METHODS: One of the more recently reported proteins is ALECT-2 (leukocyte cell-derived chemotaxin 2) amyloid, found in renal specimens of Hispanic patients. Here we report the first case of hepatic ALECT-2 amyloidosis diagnosed by LMD-MS from a liver biopsy specimen of a 52-year-old Hispanic man and causing portal hypertension with recurrent esophageal variceal bleeding. CONCLUSIONS: ALECT-2 can cause amyloidosis in organs other than the kidneys. It should be strongly considered in Hispanic patients and in those with a globular pattern of amyloid deposition. The incidence of ALECT-2 amyloidosis is likely underreported.
Entities:
Keywords:
ALECT-2; Amyloidosis; Laser microdissection and mass spectrometry (LMD-MS)