Literature DB >> 2443473

A new anti-human immunodeficiency virus substance, glycyrrhizin sulfate; endowment of glycyrrhizin with reverse transcriptase-inhibitory activity by chemical modification.

H Nakashima1, T Matsui, O Yoshida, Y Isowa, Y Kido, Y Motoki, M Ito, S Shigeta, T Mori, N Yamamoto.   

Abstract

Glycyrrhizin sulfate (GLS) was synthesized and investigated for antiviral effect on the human immunodeficiency virus (HIV) in vitro in comparison with the parental anti-HIV compound glycyrrhizin (GL). In MT-4 cells after HIV infection, the virus-induced cytopathic effect and the expression of viral antigens were inhibited by 0.25 mg/ml (0.184 mM) of GLS. Moreover, GLS completely inhibited HIV-induced plaque formation in MT-4 cells at a concentration of 1 mg/ml (736 microM), the 50% inhibitory dose being 0.055 mg/ml (40 microM). GLS was found to be an efficient inhibitor of reverse transcriptase. The effect of GLS was 4 times stronger than that of GL in molar terms.

Entities:  

Mesh：

Substances：

Year:  1987        PMID： 2443473

Source DB:  PubMed          Journal:  Jpn J Cancer Res        ISSN： 0910-5050


  8 in total

1.  Inhibition of the activity of recombinant HIV-1 integrase by derivatives of higher terpenoids.

Authors:  E A Semenova; O A Plyasunova; N I Petrenko; N V Uzenkova; E E Shul'ts; G A Tolstikov; A G Pokrovskii
Journal:  Dokl Biochem Biophys       Date:  2003 Jul-Aug       Impact factor: 0.788

Review 2.  Antiviral therapy for human immunodeficiency virus infections.

Authors:  E De Clercq
Journal:  Clin Microbiol Rev       Date:  1995-04       Impact factor: 26.132

3.  Purification and characterization of an avian myeloblastosis and human immunodeficiency virus reverse transcriptase inhibitor, sulfated polysaccharides extracted from sea algae.

Authors:  H Nakashima; Y Kido; N Kobayashi; Y Motoki; M Neushul; N Yamamoto
Journal:  Antimicrob Agents Chemother       Date:  1987-10       Impact factor: 5.191

4.  Modulation by glycyrrhizin of the cell-surface expression of H-2 class I antigens on murine tumour cell lines and normal cell populations.

Authors:  Y H Zhang; T Yoshida; K Isobe; S M Rahman; F Nagase; L Ding; I Nakashima
Journal:  Immunology       Date:  1990-07       Impact factor: 7.397

5.  Role of human immunodeficiency virus (HIV) type 1 envelope in the anti-HIV activity of the betulinic acid derivative IC9564.

Authors:  S L Holz-Smith; I C Sun; L Jin; T J Matthews; K H Lee; C H Chen
Journal:  Antimicrob Agents Chemother       Date:  2001-01       Impact factor: 5.191

6.  Rapid screening method with a cell multisizer for inhibitors of human immunodeficiency virus-induced cell fusion in vitro.

Authors:  H Nakashima; A Tanabe; T S Tochikura; N Yamamoto
Journal:  J Clin Microbiol       Date:  1988-06       Impact factor: 5.948

7.  Inhibition of Homophilic Interactions and Ligand Binding of the Receptor for Advanced Glycation End Products by Heparin and Heparin-Related Carbohydrate Structures.

Authors:  Ari Rouhiainen; Niko-Petteri Nykänen; Juha Kuja-Panula; Päivi Vanttola; Henri J Huttunen; Heikki Rauvala
Journal:  Medicines (Basel)       Date:  2018-07-30

8.  Effect of Jakyakgamcho-Tang Extracts on H2O2-Induced C2C12 Myoblasts.

Authors:  Young Sook Kim; Heung Joo Yuk; Dong Seon Kim
Journal:  Molecules       Date:  2021-01-04       Impact factor: 4.411
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.