Marisa M Fisher1, Deborah Lemay2, Erica A Eugster2. 1. Department of Pediatrics, Indiana University School of Medicine, Riley Hospital for Children, Indianapolis, IN. Electronic address: mamfishe@iu.edu. 2. Department of Pediatrics, Indiana University School of Medicine, Riley Hospital for Children, Indianapolis, IN.
Abstract
OBJECTIVES: To determine time to menarche in girls and testicular volume increase in boys after removal of a histrelin implant, which causes profound hypothalamic-pituitary-gonadal axis suppression. STUDY DESIGN: Medical records of patients treated with a histrelin implant were reviewed. Seventy-one patients (56 girls) treated with the histrelin implant were identified, of these patients, 37 explanted girls (68% naïve) and 6 explanted boys (83% naïve) were included in the analysis. Time to menarche after explantation in girls and time to testicular volume increase after explantation in boys were determined. Additional variables investigated included indication for and duration of treatment, history of menarche (girls), previous therapy, and age at beginning and end of histrelin treatment. RESULTS: Of the girls, 30 were treated for central precocious puberty (CPP), 26 had menarche at an average of 12.75 months after explantation. Of the 30, 7 were treated for other indications, of whom 6 had reached menarche. In girls with CPP, older age at explantation correlated with sooner menarche (P = .04). All boys achieved spontaneous testicular enlargement within 1 year of explantation. CONCLUSIONS: This study documented resumption of puberty after histrelin explantation in treatment naïve and non-naïve boys and girls with and without CPP. Menarche in girls with CPP occurs within a similar timeframe to that observed after other treatment approaches.
OBJECTIVES: To determine time to menarche in girls and testicular volume increase in boys after removal of a histrelin implant, which causes profound hypothalamic-pituitary-gonadal axis suppression. STUDY DESIGN: Medical records of patients treated with a histrelin implant were reviewed. Seventy-one patients (56 girls) treated with the histrelin implant were identified, of these patients, 37 explanted girls (68% naïve) and 6 explanted boys (83% naïve) were included in the analysis. Time to menarche after explantation in girls and time to testicular volume increase after explantation in boys were determined. Additional variables investigated included indication for and duration of treatment, history of menarche (girls), previous therapy, and age at beginning and end of histrelin treatment. RESULTS: Of the girls, 30 were treated for central precocious puberty (CPP), 26 had menarche at an average of 12.75 months after explantation. Of the 30, 7 were treated for other indications, of whom 6 had reached menarche. In girls with CPP, older age at explantation correlated with sooner menarche (P = .04). All boys achieved spontaneous testicular enlargement within 1 year of explantation. CONCLUSIONS: This study documented resumption of puberty after histrelin explantation in treatment naïve and non-naïve boys and girls with and without CPP. Menarche in girls with CPP occurs within a similar timeframe to that observed after other treatment approaches.
Authors: Alessandra Cassio; Milva O Bal; Luigi F Orsini; Antonio Balsamo; Silvia Sansavini; Monia Gennari; Enrico De Cristofaro; Alessandro Cicognani Journal: J Pediatr Date: 2006-10 Impact factor: 4.406
Authors: Erica A Eugster; William Clarke; Gad B Kletter; Peter A Lee; E Kirk Neely; Edward O Reiter; Paul Saenger; Dorothy Shulman; Lawrence Silverman; Lisa Flood; William Gray; David Tierney Journal: J Clin Endocrinol Metab Date: 2007-02-27 Impact factor: 5.958
Authors: Jean-Claude Carel; Erica A Eugster; Alan Rogol; Lucia Ghizzoni; Mark R Palmert; Franco Antoniazzi; Sheri Berenbaum; Jean-Pierre Bourguignon; George P Chrousos; Joël Coste; Sheri Deal; Liat de Vries; Carol Foster; Sabine Heger; Jack Holland; Kirsi Jahnukainen; Anders Juul; Paul Kaplowitz; Najiba Lahlou; Mary M Lee; Peter Lee; Deborah P Merke; E Kirk Neely; Wilma Oostdijk; Moshe Phillip; Robert L Rosenfield; Dorothy Shulman; Dennis Styne; Maïthé Tauber; Jan M Wit Journal: Pediatrics Date: 2009-03-30 Impact factor: 7.124
Authors: Samar Rahhal; William L Clarke; Gad B Kletter; Peter A Lee; E Kirk Neely; Edward O Reiter; Paul Saenger; Dorothy Shulman; Lawrence Silverman; Erica A Eugster Journal: Int J Pediatr Endocrinol Date: 2009-02-26