OBJECTIVES: The objectives of this study were to identify the predictors of life-threatening ventricular arrhythmias in patients with cardiac sarcoidosis (CS) and to evaluate the role of the implantable cardioverter-defibrillator (ICD) in this patient population. BACKGROUND: ICD implantation is a class IIA recommendation for patients with CS. However, some indications for ICD implantation in CS patients are still unclear and not enough data are available to establish predictors of malignant ventricular tachyarrhythmias in this group of patients. METHODS: We retrospectively identified all consecutive patients who were diagnosed with CS, during the period from March 2002 to April 2010. Cardiac rhythm devices were regularly interrogated and clinical data recorded during follow-up visits. RESULTS: Thirty-three patients (17 male) with CS were identified. The mean age was 53 ± 11. The mean left ventricular ejection fraction (LVEF) was 41 ± 18%. Thirty patients received an ICD. Twelve patients (36.3%) had sustained ventricular arrhythmias. Eleven patients received appropriate therapies and 9 patients received inappropriate shocks, representing 36.7% and 30.0% of the ICD population, respectively. Patients who received appropriate ICD therapies were younger with mean age 47.4 ± 7.8, and had a lower mean LVEF 33.0 ± 12.0 compared to those who did not receive ICD therapies (P = 0.0301 and 0.0341, respectively). There were no other demographic, clinical, electrocardiographic, electrophysiological, or imaging markers that predicted the future occurrence of appropriate ICD therapies in our cohort of patients. CONCLUSIONS: CS is strongly associated with malignant ventricular arrhythmias. No specific predictors of such tachyarrhythmias emerged, other than young age and low LVEF.
OBJECTIVES: The objectives of this study were to identify the predictors of life-threatening ventricular arrhythmias in patients with cardiac sarcoidosis (CS) and to evaluate the role of the implantable cardioverter-defibrillator (ICD) in this patient population. BACKGROUND:ICD implantation is a class IIA recommendation for patients with CS. However, some indications for ICD implantation in CSpatients are still unclear and not enough data are available to establish predictors of malignant ventricular tachyarrhythmias in this group of patients. METHODS: We retrospectively identified all consecutive patients who were diagnosed with CS, during the period from March 2002 to April 2010. Cardiac rhythm devices were regularly interrogated and clinical data recorded during follow-up visits. RESULTS: Thirty-three patients (17 male) with CS were identified. The mean age was 53 ± 11. The mean left ventricular ejection fraction (LVEF) was 41 ± 18%. Thirty patients received an ICD. Twelve patients (36.3%) had sustained ventricular arrhythmias. Eleven patients received appropriate therapies and 9 patients received inappropriate shocks, representing 36.7% and 30.0% of the ICD population, respectively. Patients who received appropriate ICD therapies were younger with mean age 47.4 ± 7.8, and had a lower mean LVEF 33.0 ± 12.0 compared to those who did not receive ICD therapies (P = 0.0301 and 0.0341, respectively). There were no other demographic, clinical, electrocardiographic, electrophysiological, or imaging markers that predicted the future occurrence of appropriate ICD therapies in our cohort of patients. CONCLUSIONS:CS is strongly associated with malignant ventricular arrhythmias. No specific predictors of such tachyarrhythmias emerged, other than young age and low LVEF.
Authors: Paco E Bravo; Ganesh Raghu; David G Rosenthal; Shana Elman; Bradley J Petek; Laurie A Soine; Jeffrey H Maki; Kelley R Branch; Sofia C Masri; Kristen K Patton; James H Caldwell; Eric V Krieger Journal: Int J Cardiol Date: 2017-03-10 Impact factor: 4.164
Authors: Felipe Kazmirczak; Ko-Hsuan Amy Chen; Selcuk Adabag; Lisa von Wald; Henri Roukoz; David G Benditt; Osama Okasha; Afshin Farzaneh-Far; Jeremy Markowitz; Prabhjot S Nijjar; Pratik S Velangi; Maneesh Bhargava; David Perlman; Sue Duval; Mehmet Akçakaya; Chetan Shenoy Journal: Circ Arrhythm Electrophysiol Date: 2019-08-21
Authors: Lynda E Rosenfeld; Mina K Chung; Clifford V Harding; Paolo Spagnolo; Johan Grunewald; Jason Appelbaum; William H Sauer; Daniel A Culver; Jose A Joglar; Ben A Lin; Christine L Jellis; Timm-Michael Dickfeld; Deborah H Kwon; Edward J Miller; Paul C Cremer; Frank Bogun; Jordana Kron; Ashley Bock; Davendra Mehta; Paul Leis; Konstantinos C Siontis; Elizabeth S Kaufman; Thomas Crawford; Peter Zimetbaum; Edwin T Zishiri; Jagmeet P Singh; Kenneth A Ellenbogen; Jonathan Chrispin; Syed Quadri; Logan L Vincent; Kristen K Patton; Steven Kalbfleish; Thomas D Callahan; Francis Murgatroyd; Marc A Judson; David Birnie; David R Okada; Christopher Maulion; Pavan Bhat; Lavanya Bellumkonda; Ron Blankstein; Richard K Cheng; Maryjane A Farr; Jerry D Estep Journal: Circ Arrhythm Electrophysiol Date: 2021-02-16
Authors: David G Rosenthal; Christina D Fang; Christopher A Groh; Gregory Nah; Eric Vittinghoff; Thomas A Dewland; Vasanth Vedantham; Gregory M Marcus Journal: J Am Heart Assoc Date: 2021-02-18 Impact factor: 5.501
Authors: Cristina Di Stefano; Giulia Bruno; Maria C Arciniegas Calle; Gayatri A Acharya; Lynn M Fussner; Patompong Ungprasert; Leslie T Cooper; Lori A Blauwet; Jay H Ryu; Patricia A Pellikka; Eva M Carmona Porquera; Hector R Villarraga Journal: BMC Cardiovasc Disord Date: 2020-01-20 Impact factor: 2.298