Literature DB >> 24431959

Swim everyday to keep dementia away.

Milind Parle1, Mani Vasudevan1, Nirmal Singh2.   

Abstract

A sound mind resides in a sound body. Many individuals with an active lifestyle show sharp mental skills at an advanced age. Regular exercise has been shown to exert numerous beneficial effects on brawn as well as brain. The present study was undertaken to evaluate the influence of swimming on memory of rodents. A specially designed hexagonal water maze was used for the swimming exposures of animals. The learning and memory parameters were measured using exteroceptive behavioral models such as Elevated plus-maze, Hebb-Williams maze and Passive avoidance apparatus. The rodents (rats and mice) were divided into twelve groups. The swimming exposure to the rodents was for 10- minute period during each session and there were two swimming exposures on each day. Rats and mice were subjected to swimming for -15 and -30 consecutive days. Control group animals were not subjected to swimming during above period. The learning index and memory score of all the animals was recorded on 1(st), 2(nd), 15(th), 16(th), 30(th) and 31(st) day employing above exteroceptive models. It was observed that rodents that underwent swimming regularly for 30- days showed sharp memories, when tested on above behavioral models whereas, control group animals showed decline in memory scores. Those animals, which underwent swimming for 15- days only showed good memory on 16(th) day, which however, declined after 30-days. These results emphasize the role of regular physical exercise particularly swimming in the maintenance and promotion of brain functions. The underlying physiological mechanism for improvement of memory appears to be the result of enhanced neurogenesis. Key PointsMaintaining brain health throughout life is an important public health goal.Our results point out that integration of exercise schedule into the life style of Alzheimer patients is advantageous and worthwhile.Exercising regularly as you get older may not only keep your body in shape, but your brains as well.

Entities:  

Keywords:  Dementia; exercise; neurogenesis; swimming

Year:  2005        PMID: 24431959      PMCID: PMC3880082     

Source DB:  PubMed          Journal:  J Sports Sci Med        ISSN: 1303-2968            Impact factor:   2.988


  38 in total

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2.  Adaptations of glutathione antioxidant system to endurance training are tissue and muscle fiber specific.

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Journal:  Am J Physiol       Date:  1997-01

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Journal:  Proc Natl Acad Sci U S A       Date:  1994-08-02       Impact factor: 11.205

4.  Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus.

Authors:  H van Praag; G Kempermann; F H Gage
Journal:  Nat Neurosci       Date:  1999-03       Impact factor: 24.884

5.  Estrogen and exercise interact to regulate brain-derived neurotrophic factor mRNA and protein expression in the hippocampus.

Authors:  N C Berchtold; J P Kesslak; C J Pike; P A Adlard; C W Cotman
Journal:  Eur J Neurosci       Date:  2001-12       Impact factor: 3.386

6.  Utility of an elevated plus-maze for the evaluation of memory in mice: effects of nootropics, scopolamine and electroconvulsive shock.

Authors:  J Itoh; T Nabeshima; T Kameyama
Journal:  Psychopharmacology (Berl)       Date:  1990       Impact factor: 4.530

7.  Voluntary exercise following traumatic brain injury: brain-derived neurotrophic factor upregulation and recovery of function.

Authors:  G S Griesbach; D A Hovda; R Molteni; A Wu; F Gomez-Pinilla
Journal:  Neuroscience       Date:  2004       Impact factor: 3.590

8.  Effect of exercise on learning, memory and levels of epinephrine in rats' hippocampus.

Authors:  Nasser Ahmadiasl; Hojjatallah Alaei; Osmo Hänninen
Journal:  J Sports Sci Med       Date:  2003-09-01       Impact factor: 2.988

9.  Treadmill exercise improves short-term memory by suppressing ischemia-induced apoptosis of neuronal cells in gerbils.

Authors:  Young-Je Sim; Sung-Soo Kim; Jee-Youn Kim; Mal-Soon Shin; Chang-Ju Kim
Journal:  Neurosci Lett       Date:  2004-12-06       Impact factor: 3.046

10.  Improvement of mouse memory by Myristica fragrans seeds.

Authors:  Milind Parle; Dinesh Dhingra; S K Kulkarni
Journal:  J Med Food       Date:  2004       Impact factor: 2.786

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Authors:  Milind Parle; Nirmal Singh; Mani Vasudevan
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5.  The Ever-Changing Morphology of Hippocampal Granule Neurons in Physiology and Pathology.

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  5 in total

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