Gargi Raychaudhuri1, Anjali Bandyopadhyay2, Dipnarayan Sarkar3, Sarbeswar Mandal3, Sajeeb Mondal4, Pradip Kumar Mitra5. 1. Department of Pathology, College of Medicine and Sagore Dutta Hospital, Kolkata, India ; Sarsuna Satellite Township, Phase - I, House No. H-1/20, Biren Roy Road (West), Kolkata, 700061 India. 2. Department of Pathology, Murshidabad Medical College and Hospital, Berhampore, India. 3. Department of Gynecology and Obstetrics, Institute of Post Graduate Medical Education and Research, Kolkata, India. 4. Department of Pathology, College of Medicine and Sagore Dutta Hospital, Kolkata, India. 5. Institute of Post Graduate Medical Education and Research, Kolkata, India.
Abstract
OBJECTIVE: To evaluate the clinical as well as histomorphologic features in different cases of endometrial hyperplasia along with its relative occurrence. MATERIALS AND METHODS: A one-and-a-half-year prospective study was conducted on histopathologically diagnosed cases of endometrial hyperplasia in a tertiary care hospital. Apart from relevant clinical findings, histomorphologic details were noted and statistically analyzed. OBSERVATIONS: Maximum number (46.5 %) of endometrial hyperplasia occurred in patients of 41-50 years age group. Majority (55.2 %) of the patients were found to be premenopausal. Menorrhagia was the most common (49.6 %) clinical presentation followed by postmenopausal bleeding (30.8 %). Simple hyperplasia without atypia was the most common type (95.6 %) followed by complex hyperplasia without atypia (3.6 %) and complex hyperplasia with atypia (0.8 %), respectively. The study of gland-stroma ratio revealed 65:35 to be the most frequent (34 %) ratio; variable-sized glands with cystic dilatation (60.4 %) was the commonest gland architecture and most of the cases (99.2 %) showed the absence of atypia. Associated histopathological findings included a case each of endometrial adenocarcinoma and undifferentiated endometrial stromal sarcoma along with the common leiomyoma and progesterone effects. CONCLUSION: Menorrhagia was the most common presenting complaint in cases of endometrial hyperplasia. The cases were mostly in the premenopausal age group. Simple endometrial hyperplasia without atypia was the commonest type diagnosed histopathologically. Histopathological examination along with clinical details is essential to give the final opinion regarding the diagnosis.
OBJECTIVE: To evaluate the clinical as well as histomorphologic features in different cases of endometrial hyperplasia along with its relative occurrence. MATERIALS AND METHODS: A one-and-a-half-year prospective study was conducted on histopathologically diagnosed cases of endometrial hyperplasia in a tertiary care hospital. Apart from relevant clinical findings, histomorphologic details were noted and statistically analyzed. OBSERVATIONS: Maximum number (46.5 %) of endometrial hyperplasia occurred in patients of 41-50 years age group. Majority (55.2 %) of the patients were found to be premenopausal. Menorrhagia was the most common (49.6 %) clinical presentation followed by postmenopausal bleeding (30.8 %). Simple hyperplasia without atypia was the most common type (95.6 %) followed by complex hyperplasia without atypia (3.6 %) and complex hyperplasia with atypia (0.8 %), respectively. The study of gland-stroma ratio revealed 65:35 to be the most frequent (34 %) ratio; variable-sized glands with cystic dilatation (60.4 %) was the commonest gland architecture and most of the cases (99.2 %) showed the absence of atypia. Associated histopathological findings included a case each of endometrial adenocarcinoma and undifferentiated endometrial stromal sarcoma along with the common leiomyoma and progesterone effects. CONCLUSION:Menorrhagia was the most common presenting complaint in cases of endometrial hyperplasia. The cases were mostly in the premenopausal age group. Simple endometrial hyperplasia without atypia was the commonest type diagnosed histopathologically. Histopathological examination along with clinical details is essential to give the final opinion regarding the diagnosis.
Authors: J V Lacey; O B Ioffe; B M Ronnett; B B Rush; D A Richesson; N Chatterjee; B Langholz; A G Glass; M E Sherman Journal: Br J Cancer Date: 2007-11-20 Impact factor: 7.640
Authors: A V Kubyshkin; L L Aliev; I I Fomochkina; Ye P Kovalenko; S V Litvinova; T G Filonenko; N V Lomakin; V A Kubyshkin; O V Karapetian Journal: Inflamm Res Date: 2016-06-16 Impact factor: 4.575