Literature DB >> 2442981

Oxatomide inhibits the release of bronchoconstrictor arachidonic acid metabolites (iLTC4 and PGD2) from rat mast cells and guinea-pig lung.

Y Kosaka, H Kawabe, A Ishii.   

Abstract

The effect of oxatomide, an orally active antiallergic drug, on immunoreactive LTC4 (iLTC4) production has been studied in rat peritoneal exudate cells (PEC) and guinea-pig lung fragments using the calcium ionophore A23187 and specific antigen in vitro. Oxatomide (10(-5) M) inhibited iLTC4 release by 70% with A23187 from rat PEC, and by 48% with antigen from guinea-pig lung. Oxatomide is supposed to affect the biosynthesis pathway of leukotrienes, because oxatomide inhibits 5-lipoxygenase from guinea-pig peritoneal leukocytes with an IC50 17 microM. Oxatomide also depressed the release of PGD2 from rat peritoneal mast cells stimulated by A23187 (IC50 4.2 microM). The effects of oxatomide on iLTC4 and PGD2 release were more potent than other antiallergic drugs (DSCG, ketotifen, tranilast).

Entities:  

Mesh：

Substances：

Year:  1987        PMID： 2442981     DOI： 10.1007/bf01974917

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  29 in total

1.  Disodium cromoglycate. Activity in three in vitro models of the immediate hypersensitivity reaction in lung.

Authors:  P Sheard; A M Blair
Journal:  Int Arch Allergy Appl Immunol       Date:  1970

2.  Role of arachidonic acid in the biosynthesis of slow reacting substance of anaphylaxis (SRS-A) from sensitized guinea pig lung fragments: evidence that SRS-A is very similar or identical structurally to nonimmunologically induced forms of SRS.

Authors:  S Watanabe-Kohno; C W Parker
Journal:  J Immunol       Date:  1980-08       Impact factor: 5.422

3.  [Pharmacological properties of N-(3',4'-dimethoxycinnamoyl) anthranilic acid (N-5'), a new anti-atopic agent. (5).--Influence of N-5' on the histamine release from peritoneal exudate cells (author's transl)].

Authors:  M Nakazawa; T Yoshimura; J Naito; H Azuma
Journal:  Nihon Yakurigaku Zasshi       Date:  1978-05

4.  Effect of arachidonic acid metabolism on the release of histamine and SRS (leukotrienes) from guinea-pig lung.

Authors:  N Chakravarty
Journal:  Agents Actions       Date:  1984-04

5.  Prostaglandin D2 in rat brain, spinal cord and pituitary: basal level and regional distribution.

Authors:  S Narumiya; T Ogorochi; K Nakao; O Hayaishi
Journal:  Life Sci       Date:  1982-11-08       Impact factor: 5.037

6.  Contractile effects of a PGH2 analog and PGD2 on intrapulmonary vessels.

Authors:  C A Gruetter; D B McNamara; A L Hyman; P J Kadowitz
Journal:  Am J Physiol       Date:  1978-02

7.  Mediators of arachidonic acid-induced contractions of indomethacin-treated guinea-pig airways: leukotrienes C4 and D4.

Authors:  J F Burka; M H Saad
Journal:  Br J Pharmacol       Date:  1984-03       Impact factor: 8.739

8.  Slow-reacting substances (leukotrienes) contract human airway and pulmonary vascular smooth muscle in vitro.

Authors:  C J Hanna; M K Bach; P D Pare; R R Schellenberg
Journal:  Nature       Date:  1981-03-26       Impact factor: 49.962

9.  [Pharmacological studies on oxatomide: (4) Effect on the histamine release from isolated rat peritoneal exudate cells (PEC) and lung slices].

Authors:  K Ohmori; H Ishii; K Shuto; N Nakamizo
Journal:  Nihon Yakurigaku Zasshi       Date:  1982-12

10.  Pharmacological study of the contractile activity of leukotriene C4 and D4 on isolated human airway smooth muscle.

Authors:  T R Jones; C Davis; E E Daniel
Journal:  Can J Physiol Pharmacol       Date:  1982-05       Impact factor: 2.273
View more
  1 in total

1.  Suppression of PAF-induced bronchoconstriction in the guinea-pig by oxatomide: mechanism of action.

Authors:  F P Nijkamp; G Folkerts; J R Beetens; F De Clerck
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1989-07       Impact factor: 3.000
  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.