P Wang1, S L Lin1, L H Zhang1, Z Li1, Q Liu2, J X Gao3, D M Liu1, J J Bo4, Y R Huang1. 1. Department of Urology, Renji Hospital, Shanghai Jiao Tong University, Shanghai, China. 2. Department of Pathology, Renji Hospital, Shanghai Jiao Tong University, Shanghai, China. 3. Clinical Stem Cell Research Center, Renji Hospital, Shanghai Jiao Tong University, Shanghai, China. 4. Department of Urology, Renji Hospital, Shanghai Jiao Tong University, Shanghai, China. Electronic address: bojuanjie@sina.com.
Abstract
OBJECTIVES: This research aims to specify the prognostic value of P-cadherin on recurrence and progression in non-muscle-invasive bladder cancers (NMIBC). METHODS: A total of 110 NMIBC cases were collected and P-cadherin protein was assessed by immunohistochemical test in these samples. Correlations between P-cadherin expression and clinicopathologic features were analyzed. For recurrence-free and progression-free survival, Kaplan-Meier log-rank test was used. Then Cox univariate and multivariate analyses were further performed. RESULTS: P-cadherin high expression correlated with tumor progression (P = 0.031). Kaplan-Meier results showed that patients with high P-cadherin expression had worse progression-free survival (P = 0.034) but not recurrence-free survival (P = 0.133) than low-expression patients. Cox regression results showed P-cadherin expression was an independent predictor for progression (P = 0.042) but not recurrence (P = 0.139) in NMIBC. CONCLUSIONS: Our results demonstrated that P-cadherin expression correlated with tumor progression and could be taken as an independent predictor for progression in NMIBC.
OBJECTIVES: This research aims to specify the prognostic value of P-cadherin on recurrence and progression in non-muscle-invasive bladder cancers (NMIBC). METHODS: A total of 110 NMIBC cases were collected and P-cadherin protein was assessed by immunohistochemical test in these samples. Correlations between P-cadherin expression and clinicopathologic features were analyzed. For recurrence-free and progression-free survival, Kaplan-Meier log-rank test was used. Then Cox univariate and multivariate analyses were further performed. RESULTS: P-cadherin high expression correlated with tumor progression (P = 0.031). Kaplan-Meier results showed that patients with high P-cadherin expression had worse progression-free survival (P = 0.034) but not recurrence-free survival (P = 0.133) than low-expression patients. Cox regression results showed P-cadherin expression was an independent predictor for progression (P = 0.042) but not recurrence (P = 0.139) in NMIBC. CONCLUSIONS: Our results demonstrated that P-cadherin expression correlated with tumor progression and could be taken as an independent predictor for progression in NMIBC.
Authors: María Victoria Mencucci; Lara Lapyckyj; Marina Rosso; María José Besso; Denise Belgorosky; Mariana Isola; Silvia Vanzulli; Catalina Lodillinsky; Ana María Eiján; Juan Carlos Tejerizo; Matías Ignacio Gonzalez; María Ercilia Zubieta; Mónica Hebe Vazquez-Levin Journal: Front Oncol Date: 2020-03-27 Impact factor: 6.244