Literature DB >> 2442883

Studies on the efficacy of DL-alpha-difluoromethylornithine (DFMO) associated with bleomycin and suramin for treatment of mice infected with metacyclic forms of Trypanosoma brucei brucei.

F Demey.   

Abstract

NMRI mice were treated with DFMO-bleomycin and DFMO-suramin drug combinations at day 8 post-inoculation. The highest percentage of parasitologically non patent mice were attained with DFMO-suramin combination treatments. Parasitological and serological examinations of the non-relapsing mice strongly suggests trypanosome clearance.

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Year:  1987        PMID： 2442883     DOI： 10.1007/bf00570924

Source DB:  PubMed          Journal:  Vet Res Commun        ISSN： 0165-7380            Impact factor:   2.459


  6 in total

1.  Trypanosoma brucei: a rapid "matching" method for estimating the host's parasitemia.

Authors:  W J Herbert; W H Lumsden
Journal:  Exp Parasitol       Date:  1976-12       Impact factor: 2.011

2.  The haematocrit centrifuge technique for the diagnosis of African trypanosomiasis.

Authors:  P T Woo
Journal:  Acta Trop       Date:  1970       Impact factor: 3.112

3.  Experimental infection with two stocks of Trypanosoma brucei gambiense. Study of the evolution by elution techniques of tissues.

Authors:  P M Mulumba; M Wéry
Journal:  Contrib Microbiol Immunol       Date:  1983

4.  New drug combination for experimental late-stage African trypanosomiasis: DL-alpha-difluoromethylornithine (DFMO) with suramin.

Authors:  A B Clarkson; E J Bienen; C J Bacchi; P P McCann; H C Nathan; S H Hutner; A Sjoerdsma
Journal:  Am J Trop Med Hyg       Date:  1984-11       Impact factor: 2.345

5.  Efficacy of combinations of difluoromethylornithine and bleomycin in a mouse model of central nervous system African trypanosomiasis.

Authors:  A B Clarkson; C J Bacchi; G H Mellow; H C Nathan; P P McCann; A Sjoerdsma
Journal:  Proc Natl Acad Sci U S A       Date:  1983-09       Impact factor: 11.205

6.  Polyamine metabolism: a potential therapeutic target in trypanosomes.

Authors:  C J Bacchi; H C Nathan; S H Hutner; P P McCann; A Sjoerdsma
Journal:  Science       Date:  1980-10-17       Impact factor: 47.728
  6 in total

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