| Literature DB >> 24428717 |
Xavier Laurent1, Benjamin Bertin, Nicolas Renault, Amaury Farce, Silvia Speca, Ophélie Milhomme, Régis Millet, Pierre Desreumaux, Eric Hénon, Philippe Chavatte.
Abstract
Since the discovery in 1995 of α-galactosylceramide 1 (α-GalCer), also known as KRN7000,1 hundreds of compounds have been synthesized in order to activate invariant natural killer T (iNKT) cells. Such keen interest for this lymphocyte cell type is due to its ability to produce different cytokines that bias the immune response toward a Th1 or Th2 profile. Thus, an understanding of the immune polarization mechanism via iNKT activation may pave the way toward new therapeutics in various domains including cancer and infectious and autoimmune diseases. In this review, we propose an up-to-date analysis of iNKT activators associated with a structure-activity relationship (SAR) study aimed at complementing available reviews by highlighting molecular bases for a selective immune response.Entities:
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Year: 2014 PMID： 24428717 DOI： 10.1021/jm4010863
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446