Can clonidine as a pre-anaesthetic drug decrease bleeding during rhinoplasty surgery?

Clonidine is an antihypertensive drug which acts through facilitation of Alph-2 post-synaptic receptors and in addition to its antihypertensive, anti-anxiety and analgesic effects, its beneficial effects in reducing the bleeding during Neurosurgery and Orthopedics surgeries, delicate surgeries of ear and nasal and sinus endoscopy have been proved. In this study we discuss the effects of this drug in reducing bleeding during rhinoplasty surgery. A double-blinded clinical trial 80 patients have been conducted 40 patients received 5 µg/Kg of oral Clonidine, and 40 patients where placebo. The patients after surgery were divided into 4 groups according to the number of bloody standard gauzes during the surgery. Group 1(less than 2 bloody gauzes), group 2(2-3 bloody gauzes), group 3(4-5 bloody gauzes), group 4(more than 5 bloody gauzes). All the graded achieved results were analyzed using Chi-Square test and Fisher test. Mean and standard deviation (SD) of the amount of bleeding in the group who were receiving Clonidine were less than the witness group. Number of the patients in groups 3 and 4 for those who were receiving Clonidine was obviously fewer (1.8 ± 0.04 vs. 3.1 ± 0.05), (P < 0.05). Oral Clonidine as a pre-anesthetic drug causes decrease in bleeding during rhinoplasty surgery.

RCT Entities:   Population Interventions Outcomes