Methyl 2-[(tert-but-oxy-carbon-yl)amino]-3-(4-hy-droxy-phen-yl)propano-ate.

In the title mol-ecule, C15H21NO5, the dihedral angle between the mean plane of the -N-C(=O)-O- group [maximum deviation = 0.002 (1) Å for the C atom] and the benzene ring is 82.2 (2)°. In the crystal, O-H⋯O and N-H⋯O hydrogen bonds connect the mol-ecules, forming a two-dimensional network parallel to (001).

Related literature

For the biological activity of related compounds, see: Sykes et al. (1999 ▶).

Experimental

Crystal data

C15H21NO5

M = 295.33

Orthorhombic,

a = 8.7879 (8) Å

b = 9.4844 (9) Å

c = 18.9207 (18) Å

V = 1577.0 (3) Å3

Z = 4

Mo Kα radiation

μ = 0.09 mm−1

T = 100 K

0.55 × 0.49 × 0.45 mm

Data collection

Bruker APEXII CCD diffractometer

Absorption correction: multi-scan (SADABS; Sheldrick, 1996 ▶) T min = 0.962, T max = 0.989

9339 measured reflections

3636 independent reflections

3469 reflections with I > 2σ(I)

R int = 0.072

Refinement

R[F 2 > 2σ(F 2)] = 0.039

wR(F 2) = 0.102

S = 1.03

3636 reflections

190 parameters

H-atom parameters constrained

Δρmax = 0.32 e Å−3

Δρmin = −0.20 e Å−3

Data collection: APEX2 (Bruker, 2007 ▶); cell refinement: APEX2; data reduction: SAINT (Bruker, 2007 ▶)’; program(s) used to solve structure: SHELXTL (Sheldrick, 2008 ▶); program(s) used to refine structure: SHELXTL; molecular graphics: SHELXTL and PLATON (Spek, 2009 ▶); software used to prepare material for publication: SHELXTL and publCIF (Westrip, 2010 ▶).

Crystal structure: contains datablock(s) I, global. DOI: 10.1107/S160053681301979X/lh5632sup1.cif

Structure factors: contains datablock(s) I. DOI: 10.1107/S160053681301979X/lh5632Isup2.hkl

Click here for additional data file.

Supplementary material file. DOI: 10.1107/S160053681301979X/lh5632Isup3.cml

Additional supplementary materials: crystallographic information; 3D view; checkCIF report

C15H21NO5	F(000) = 632
Mr = 295.33	Dx = 1.244 Mg m−3
Orthorhombic, P212121	Mo Kα radiation, λ = 0.71073 Å
Hall symbol: P 2ac 2ab	Cell parameters from 9371 reflections
a = 8.7879 (8) Å	θ = 1.0–27.6°
b = 9.4844 (9) Å	µ = 0.09 mm−1
c = 18.9207 (18) Å	T = 100 K
V = 1577.0 (3) Å3	Block, colourless
Z = 4	0.55 × 0.49 × 0.45 mm

Bruker APEXII CCD diffractometer	3636 independent reflections
Radiation source: fine-focus sealed tube	3469 reflections with I > 2σ(I)
Graphite monochromator	Rint = 0.072
φ and ω scans	θmax = 27.6°, θmin = 2.2°
Absorption correction: multi-scan (SADABS; Sheldrick, 1996)	h = −11→9
Tmin = 0.962, Tmax = 0.989	k = −12→8
9339 measured reflections	l = −24→24

Refinement on F2	Primary atom site location: structure-invariant direct methods
Least-squares matrix: full	Secondary atom site location: difference Fourier map
R[F2 > 2σ(F2)] = 0.039	Hydrogen site location: inferred from neighbouring sites
wR(F2) = 0.102	H-atom parameters constrained
S = 1.03	w = 1/[σ2(Fo2) + (0.0581P)2 + 0.1712P] where P = (Fo2 + 2Fc2)/3
3636 reflections	(Δ/σ)max = 0.008
190 parameters	Δρmax = 0.32 e Å−3
0 restraints	Δρmin = −0.20 e Å−3

Geometry. All e.s.d.'s (except the e.s.d. in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell e.s.d.'s are taken into account individually in the estimation of e.s.d.'s in distances, angles and torsion angles; correlations between e.s.d.'s in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell e.s.d.'s is used for estimating e.s.d.'s involving l.s. planes.

Refinement. Refinement of F2 against ALL reflections. The weighted R-factor wR and goodness of fit S are based on F2, conventional R-factors R are based on F, with F set to zero for negative F2. The threshold expression of F2 > σ(F2) is used only for calculating R-factors(gt) etc. and is not relevant to the choice of reflections for refinement. R-factors based on F2 are statistically about twice as large as those based on F, and R-factors based on ALL data will be even larger.

	x	y	z	Uiso*/Ueq
C1	−0.04196 (17)	1.13511 (15)	0.18071 (7)	0.0216 (3)
H1A	−0.1123	1.1434	0.2172	0.026*
C2	−0.03335 (16)	1.01206 (15)	0.14197 (7)	0.0205 (3)
H2A	−0.0978	0.9376	0.1531	0.025*
C3	0.07017 (15)	0.99675 (14)	0.08627 (7)	0.0172 (3)
C4	0.16908 (15)	1.10800 (15)	0.07254 (7)	0.0192 (3)
H4A	0.2409	1.0991	0.0367	0.023*
C5	0.16250 (16)	1.23229 (15)	0.11142 (7)	0.0200 (3)
H5A	0.2297	1.3055	0.1016	0.024*
C6	0.05528 (16)	1.24689 (14)	0.16488 (7)	0.0184 (3)
C7	0.06700 (17)	0.86702 (15)	0.04022 (7)	0.0188 (3)
H7A	0.1336	0.8823	0.0001	0.023*
H7B	−0.0354	0.8547	0.0221	0.023*
C8	0.11575 (14)	0.73007 (14)	0.07772 (7)	0.0166 (3)
H8A	0.0573	0.7217	0.1216	0.020*
C9	0.33960 (15)	0.64306 (14)	0.13963 (7)	0.0159 (3)
C10	0.59030 (15)	0.56854 (15)	0.18449 (7)	0.0199 (3)
C11	0.5429 (2)	0.5555 (2)	0.26171 (8)	0.0302 (3)
H11A	0.5434	0.6471	0.2833	0.045*
H11B	0.6131	0.4950	0.2861	0.045*
H11C	0.4424	0.5161	0.2644	0.045*
C12	0.59178 (18)	0.42703 (17)	0.14678 (8)	0.0280 (3)
H12A	0.6225	0.4403	0.0985	0.042*
H12B	0.4917	0.3866	0.1480	0.042*
H12C	0.6621	0.3649	0.1699	0.042*
C13	0.74355 (17)	0.64103 (19)	0.17817 (9)	0.0305 (3)
H13A	0.7714	0.6480	0.1292	0.046*
H13B	0.8190	0.5872	0.2030	0.046*
H13C	0.7373	0.7338	0.1982	0.046*
C14	0.1469 (2)	0.42237 (17)	−0.04498 (8)	0.0292 (3)
H14A	0.2370	0.3749	−0.0609	0.044*
H14B	0.0943	0.4618	−0.0848	0.044*
H14C	0.0816	0.3563	−0.0213	0.044*
C15	0.07176 (16)	0.60783 (14)	0.02939 (7)	0.0180 (3)
N1	0.27499 (13)	0.73700 (12)	0.09567 (6)	0.0170 (2)
H1B	0.3301	0.8029	0.0778	0.020*
O1	0.04029 (13)	1.36708 (11)	0.20398 (5)	0.0247 (2)
H1C	0.1090	1.4220	0.1939	0.037*
O2	0.18880 (11)	0.53485 (11)	0.00379 (5)	0.0221 (2)
O3	−0.05943 (13)	0.58394 (11)	0.01458 (6)	0.0254 (2)
O4	0.48955 (11)	0.66726 (10)	0.14566 (5)	0.0186 (2)
O5	0.27010 (12)	0.54940 (10)	0.16994 (5)	0.0204 (2)

	U11	U22	U33	U12	U13	U23
C1	0.0215 (7)	0.0263 (7)	0.0171 (6)	−0.0023 (6)	0.0044 (5)	0.0007 (5)
C2	0.0205 (6)	0.0205 (6)	0.0206 (6)	−0.0054 (5)	0.0015 (5)	0.0015 (5)
C3	0.0161 (6)	0.0182 (6)	0.0172 (6)	0.0019 (5)	−0.0039 (5)	0.0011 (5)
C4	0.0145 (6)	0.0235 (7)	0.0195 (6)	0.0009 (5)	0.0020 (5)	0.0009 (5)
C5	0.0176 (6)	0.0208 (6)	0.0217 (6)	−0.0034 (5)	0.0006 (5)	0.0018 (5)
C6	0.0200 (6)	0.0185 (6)	0.0167 (5)	−0.0002 (5)	−0.0023 (5)	0.0006 (5)
C7	0.0179 (6)	0.0208 (6)	0.0178 (6)	0.0018 (5)	−0.0025 (5)	−0.0009 (5)
C8	0.0116 (6)	0.0203 (6)	0.0178 (6)	−0.0004 (5)	−0.0014 (5)	−0.0005 (5)
C9	0.0152 (6)	0.0171 (6)	0.0155 (5)	−0.0002 (5)	0.0007 (5)	−0.0038 (5)
C10	0.0145 (6)	0.0248 (7)	0.0206 (6)	0.0027 (5)	−0.0050 (5)	0.0017 (5)
C11	0.0281 (8)	0.0429 (9)	0.0196 (6)	0.0005 (7)	−0.0040 (6)	0.0012 (6)
C12	0.0281 (8)	0.0264 (7)	0.0296 (7)	0.0064 (6)	−0.0033 (6)	0.0000 (6)
C13	0.0146 (7)	0.0421 (9)	0.0348 (8)	−0.0032 (6)	−0.0069 (6)	0.0052 (7)
C14	0.0364 (9)	0.0281 (7)	0.0232 (7)	−0.0031 (7)	0.0026 (6)	−0.0084 (6)
C15	0.0164 (6)	0.0189 (6)	0.0188 (6)	−0.0003 (5)	−0.0011 (5)	0.0037 (5)
N1	0.0129 (5)	0.0185 (5)	0.0196 (5)	−0.0023 (4)	−0.0008 (4)	0.0012 (4)
O1	0.0269 (5)	0.0215 (5)	0.0256 (5)	−0.0057 (4)	0.0063 (4)	−0.0059 (4)
O2	0.0191 (5)	0.0249 (5)	0.0224 (5)	−0.0012 (4)	0.0020 (4)	−0.0060 (4)
O3	0.0179 (5)	0.0250 (5)	0.0333 (5)	−0.0016 (4)	−0.0080 (4)	−0.0020 (4)
O4	0.0123 (4)	0.0210 (5)	0.0223 (4)	−0.0010 (3)	−0.0038 (4)	0.0031 (4)
O5	0.0175 (5)	0.0214 (5)	0.0221 (4)	−0.0027 (4)	0.0013 (4)	0.0028 (4)

C1—C2	1.380 (2)	C10—O4	1.4834 (16)
C1—C6	1.3942 (19)	C10—C13	1.517 (2)
C1—H1A	0.9300	C10—C12	1.520 (2)
C2—C3	1.3997 (19)	C10—C11	1.524 (2)
C2—H2A	0.9300	C11—H11A	0.9600
C3—C4	1.3915 (19)	C11—H11B	0.9600
C3—C7	1.5079 (18)	C11—H11C	0.9600
C4—C5	1.391 (2)	C12—H12A	0.9600
C4—H4A	0.9300	C12—H12B	0.9600
C5—C6	1.3893 (19)	C12—H12C	0.9600
C5—H5A	0.9300	C13—H13A	0.9600
C6—O1	1.3653 (16)	C13—H13B	0.9600
C7—C8	1.5408 (19)	C13—H13C	0.9600
C7—H7A	0.9700	C14—O2	1.4578 (17)
C7—H7B	0.9700	C14—H14A	0.9600
C8—N1	1.4415 (16)	C14—H14B	0.9600
C8—C15	1.5265 (18)	C14—H14C	0.9600
C8—H8A	0.9800	C15—O3	1.2079 (18)
C9—O5	1.2210 (17)	C15—O2	1.3309 (17)
C9—O4	1.3424 (16)	N1—H1B	0.8600
C9—N1	1.3447 (17)	O1—H1C	0.8200
C2—C1—C6	119.69 (13)	O4—C10—C11	111.29 (12)
C2—C1—H1A	120.2	C13—C10—C11	110.79 (12)
C6—C1—H1A	120.2	C12—C10—C11	112.37 (13)
C1—C2—C3	121.55 (13)	C10—C11—H11A	109.5
C1—C2—H2A	119.2	C10—C11—H11B	109.5
C3—C2—H2A	119.2	H11A—C11—H11B	109.5
C4—C3—C2	117.90 (12)	C10—C11—H11C	109.5
C4—C3—C7	121.49 (12)	H11A—C11—H11C	109.5
C2—C3—C7	120.51 (12)	H11B—C11—H11C	109.5
C5—C4—C3	121.20 (12)	C10—C12—H12A	109.5
C5—C4—H4A	119.4	C10—C12—H12B	109.5
C3—C4—H4A	119.4	H12A—C12—H12B	109.5
C6—C5—C4	119.85 (12)	C10—C12—H12C	109.5
C6—C5—H5A	120.1	H12A—C12—H12C	109.5
C4—C5—H5A	120.1	H12B—C12—H12C	109.5
O1—C6—C5	122.90 (12)	C10—C13—H13A	109.5
O1—C6—C1	117.34 (12)	C10—C13—H13B	109.5
C5—C6—C1	119.75 (12)	H13A—C13—H13B	109.5
C3—C7—C8	114.62 (10)	C10—C13—H13C	109.5
C3—C7—H7A	108.6	H13A—C13—H13C	109.5
C8—C7—H7A	108.6	H13B—C13—H13C	109.5
C3—C7—H7B	108.6	O2—C14—H14A	109.5
C8—C7—H7B	108.6	O2—C14—H14B	109.5
H7A—C7—H7B	107.6	H14A—C14—H14B	109.5
N1—C8—C15	114.93 (11)	O2—C14—H14C	109.5
N1—C8—C7	109.87 (11)	H14A—C14—H14C	109.5
C15—C8—C7	107.10 (10)	H14B—C14—H14C	109.5
N1—C8—H8A	108.2	O3—C15—O2	123.75 (13)
C15—C8—H8A	108.2	O3—C15—C8	121.54 (12)
C7—C8—H8A	108.2	O2—C15—C8	114.67 (11)
O5—C9—O4	125.14 (13)	C9—N1—C8	121.70 (11)
O5—C9—N1	124.15 (13)	C9—N1—H1B	119.2
O4—C9—N1	110.71 (12)	C8—N1—H1B	119.2
O4—C10—C13	101.82 (11)	C6—O1—H1C	109.5
O4—C10—C12	109.26 (11)	C15—O2—C14	114.55 (12)
C13—C10—C12	110.83 (13)	C9—O4—C10	121.33 (11)

D—H···A	D—H	H···A	D···A	D—H···A
N1—H1B···O3i	0.86	2.27	3.0583 (16)	153
O1—H1C···O5ii	0.82	1.92	2.7356 (15)	180

Table 1

Hydrogen-bond geometry (Å, °)

D—H⋯A	D—H	H⋯A	D⋯A	D—H⋯A
N1—H1B⋯O3i	0.86	2.27	3.0583 (16)	153
O1—H1C⋯O5ii	0.82	1.92	2.7356 (15)	180

Symmetry codes: (i) ; (ii) .