Literature DB >> 24426369

Acquired Factor VIII Inhibitor: A Rare Etiology for Bruisability and Anemia.

Srikanth Seethala1, Keith Barnes1, Javier Corral1.   

Abstract

Acquired factor VIII inhibitor is a very rare cause of easy bruisability, muscular hematomas, and subsequent anemia in the elderly patient population. The incidence of acquired factor VIII inhibitor is one in one million. Here we report an elderly patient who presented to the hospital for bruising easily fatigue and was found to have acquired factor VIII inhibitor on further investigation. He responded to the treatment appropriately, and hemostasis was achieved successfully with recombinant VII concentrates and eradication of the inhibitor with Imuran and steroid combination.

Entities:  

Keywords:  Acquired factor VIII inhibitor; Anemia; Bruisability; Hematomas; Hemostasis

Year:  2012        PMID: 24426369      PMCID: PMC3710562          DOI: 10.1007/s12288-012-0174-7

Source DB:  PubMed          Journal:  Indian J Hematol Blood Transfus        ISSN: 0971-4502            Impact factor:   0.900


  6 in total

Review 1.  Acquired haemophilia: review and meta-analysis focused on therapy and prognostic factors.

Authors:  Julio Delgado; Victor Jimenez-Yuste; Fernando Hernandez-Navarro; Ana Villar
Journal:  Br J Haematol       Date:  2003-04       Impact factor: 6.998

2.  Successful eradication of acquired factor-VIII-inhibitor using single low-dose rituximab.

Authors:  Martin Wermke; Malte von Bonin; Siegmund Gehrisch; Gabriele Siegert; Gerhard Ehninger; Uwe Platzbecker
Journal:  Haematologica       Date:  2009-11-10       Impact factor: 9.941

Review 3.  Inhibitors of propagation of coagulation (factors VIII, IX and XI): a review of current therapeutic practice.

Authors:  Massimo Franchini; Pier Mannuccio Mannucci
Journal:  Br J Clin Pharmacol       Date:  2011-10       Impact factor: 4.335

Review 4.  Acquired factor VIII inhibitors: pathophysiology and treatment.

Authors:  Alice D Ma; Daniel Carrizosa
Journal:  Hematology Am Soc Hematol Educ Program       Date:  2006

Review 5.  Acquired factor VIII inhibitors.

Authors:  Massimo Franchini; Giuseppe Lippi
Journal:  Blood       Date:  2008-05-07       Impact factor: 22.113

6.  International recommendations on the diagnosis and treatment of patients with acquired hemophilia A.

Authors:  Angela Huth-Kühne; Francesco Baudo; Peter Collins; Jørgen Ingerslev; Craig M Kessler; Hervé Lévesque; Maria Eva Mingot Castellano; Midori Shima; Jean St-Louis
Journal:  Haematologica       Date:  2009-04       Impact factor: 9.941

  6 in total
  1 in total

1.  An Unusual Etiology for Elevation of Activated Partial Thromboplastin Time (aPTT) in SLE: Acquired Hemophilia and Lupus Anticoagulant.

Authors:  Srikanth Seethala; Nathaniel P Collins; George Comerci
Journal:  Case Rep Hematol       Date:  2013-09-26
  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.