Literature DB >> 24425959

Differentiation- and apoptosis-inducing activities of rice bran extracts in a human colon cancer cell line.

Akiko Takashima1, Masanobu Ohtomo1, Tsugio Kikuchi1, Jun Iwashita2, Tatsuya Abe2, Keishi Hata3.   

Abstract

Rice bran water extract (RBWE) and ethanol extract (RBEE) at 1.0 mg/ml markedly inhibited the proliferation of LS174T human colon cancer cells. RBEE but not RBWE induced apoptosis. RBWE promoted the production of intestinal mucin (MUC2). Real-time RT-PCR demonstrated that RBWE up-regulated the expression of MUC2 and sucrase-isomaltase complex (a differentiation marker of colon cancer cells), and attenuated that of proliferating cell nuclear antigen at the mRNA level in a dose-dependent manner. These findings suggested that RBWE suppress the proliferation of colon cancer cells by inducting differentiation not apoptosis.

Entities:  

Keywords:  Colon cancer differentiation; Intestinal mucin; Proliferating cell nuclear antigen; Rice bran extract

Year:  2011        PMID： 24425959      PMCID： PMC3602568          DOI： 10.1007/s13197-011-0368-2

Source DB:  PubMed          Journal:  J Food Sci Technol        ISSN： 0022-1155            Impact factor:   2.701


  19 in total

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Journal:  J Histochem Cytochem       Date:  1999-08       Impact factor: 2.479

2.  Characterization of potentially chemopreventive phenols in extracts of brown rice that inhibit the growth of human breast and colon cancer cells.

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Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2000-11       Impact factor: 4.254

3.  Comparative effects of three cereal brans on plasma lipids, blood pressure, and glucose metabolism in mildly hypercholesterolemic men.

Authors:  M Kestin; R Moss; P M Clifton; P J Nestel
Journal:  Am J Clin Nutr       Date:  1990-10       Impact factor: 7.045

4.  Full-fat rice bran and oat bran similarly reduce hypercholesterolemia in humans.

Authors:  A L Gerhardt; N B Gallo
Journal:  J Nutr       Date:  1998-05       Impact factor: 4.798

5.  Muc2-deficient mice spontaneously develop colitis, indicating that MUC2 is critical for colonic protection.

Authors:  Maria Van der Sluis; Barbara A E De Koning; Adrianus C J M De Bruijn; Anna Velcich; Jules P P Meijerink; Johannes B Van Goudoever; Hans A Büller; Jan Dekker; Isabelle Van Seuningen; Ingrid B Renes; Alexandra W C Einerhand
Journal:  Gastroenterology       Date:  2006-07       Impact factor: 22.682

6.  Induction of markers of normal differentiation in human colon carcinoma cells by the v-rasH oncogene.

Authors:  P Celano; C M Berchtold; M Mabry; M Carroll; D Sidransky; R A Casero; R Lupu
Journal:  Cell Growth Differ       Date:  1993-04

7.  Antioxidative effects of a processed grain food.

Authors:  Y Minamiyama; T Yoshikawa; T Tanigawa; S Takahashi; Y Naito; H Ichikawa; M Kondo
Journal:  J Nutr Sci Vitaminol (Tokyo)       Date:  1994-10       Impact factor: 2.000

8.  Down-regulation of proliferating cell nuclear antigen gene expression occurs during cell cycle arrest induced by human fecal water in colonic HT-29 cells.

Authors:  Huawei Zeng; Cindy D Davis
Journal:  J Nutr       Date:  2003-08       Impact factor: 4.798

Review 9.  Dietary histone deacetylase inhibitors: from cells to mice to man.

Authors:  Roderick H Dashwood; Emily Ho
Journal:  Semin Cancer Biol       Date:  2007-05-05       Impact factor: 15.707

10.  Evaluation of the cancer chemopreventive efficacy of rice bran in genetic mouse models of breast, prostate and intestinal carcinogenesis.

Authors:  R D Verschoyle; P Greaves; H Cai; R E Edwards; W P Steward; A J Gescher
Journal:  Br J Cancer       Date:  2007-01-09       Impact factor: 7.640
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  5 in total

1.  Chemopreventive Effects of Germinated Rough Rice Crude Extract in Inhibiting Azoxymethane-Induced Aberrant Crypt Foci Formation in Sprague-Dawley Rats.

Authors:  Elnaz Saki; Latifah Saiful Yazan; Razana Mohd Ali; Zalinah Ahmad
Journal:  Biomed Res Int       Date:  2017-01-02       Impact factor: 3.411

Review 2.  Scientific Evidence of Rice By-Products for Cancer Prevention: Chemopreventive Properties of Waste Products from Rice Milling on Carcinogenesis In Vitro and In Vivo.

Authors:  Bee Ling Tan; Mohd Esa Norhaizan
Journal:  Biomed Res Int       Date:  2017-01-22       Impact factor: 3.411

Review 3.  The anti-cancer activity and potential clinical application of rice bran extracts and fermentation products.

Authors:  Yonghui Yu; Jingjie Zhang; Jing Wang; Baogao Sun
Journal:  RSC Adv       Date:  2019-06-10       Impact factor: 4.036

4.  Antitumor properties of two traditional aromatic rice genotypes (Kalijira and Chinigura).

Authors:  Mohammad Abdul Mannan; Tushar Chandra Sarker; Ahmad Humayan Kabir; Mostafizur Rahman; Mohammad Firoz Alam
Journal:  Avicenna J Phytomed       Date:  2014-01

5.  Rice bran mineral extract increases the expression of anagen-related molecules in human dermal papilla through wnt/catenin pathway.

Authors:  Yu-Mi Kim; Soon-Joung Kwon; Hyun-Joon Jang; Young-Kwon Seo
Journal:  Food Nutr Res       Date:  2017-12-05       Impact factor: 3.894
  5 in total

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