Literature DB >> 24424865

Diagnosis of melioidosis by means of an ELISA detecting antibodies toPseudomonas pseudomallei exotoxin. Preliminary assay evaluation.

C J Smith1, M Jones, D A Dance, W Chaowagul, N J White.   

Abstract

An ELISA system for the detection of human antibodies toPseudomonas pseudomallei exotoxin is described. Analysis of control sera and sera from patients with culture-positive melioidosis showed that both IgG and IgM antibodies to exotoxin were detectable in patients with melioidosis. This implies that the exotoxin is producedin vivo byP. pseudomallei, and may be involved in the pathogenesis of melioidosis. Furthermore, these rapid and simple assays may prove to be useful for the serodiagnosis of the disease.

Entities:  

Year:  1991        PMID： 24424865     DOI： 10.1007/BF02310916

Source DB:  PubMed          Journal:  World J Microbiol Biotechnol        ISSN： 0959-3993            Impact factor:   3.312


  13 in total

Review 1.  Clinical and laboratory studies of malaria and melioidosis.

Authors:  N J White; D A Dance
Journal:  Trans R Soc Trop Med Hyg       Date:  1988       Impact factor: 2.184

2.  Halving of mortality of severe melioidosis by ceftazidime.

Authors:  N J White; D A Dance; W Chaowagul; Y Wattanagoon; V Wuthiekanun; N Pitakwatchara
Journal:  Lancet       Date:  1989-09-23       Impact factor: 79.321

3.  A competitive immunosorbent assay for detection of Pseudomonas pseudomallei exotoxin.

Authors:  G Ismail; M Noor Embi; O Omar; J C Allen; C J Smith
Journal:  J Med Microbiol       Date:  1987-06       Impact factor: 2.472

4.  Demonstration of human antibodies to Pseudomonas pseudomallei by indirect fluorescent antibody staining.

Authors:  L R Ashdown
Journal:  Pathology       Date:  1981-07       Impact factor: 5.306

5.  Melioidosis: a major cause of community-acquired septicemia in northeastern Thailand.

Authors:  W Chaowagul; N J White; D A Dance; Y Wattanagoon; P Naigowit; T M Davis; S Looareesuwan; N Pitakwatchara
Journal:  J Infect Dis       Date:  1989-05       Impact factor: 5.226

6.  Application of indirect hemagglutination test and indirect fluorescent antibody test for IgM antibody for diagnosis of melioidosis in Thailand.

Authors:  K Khupulsup; B Petchclai
Journal:  Am J Trop Med Hyg       Date:  1986-03       Impact factor: 2.345

7.  Serological diagnosis of human melioidosis with indirect hemagglutination and complement fixation tests.

Authors:  A D Alexander; D L Huxsoll; A R Warner; V Shepler; A Dorsey
Journal:  Appl Microbiol       Date:  1970-11

8.  Protective activity of antibodies to exotoxin A and lipopolysaccharide at the onset of Pseudomonas aeruginosa septicemia in man.

Authors:  M Pollack; L S Young
Journal:  J Clin Invest       Date:  1979-02       Impact factor: 14.808

9.  Enzyme-linked immunosorbent assay for the diagnosis of clinical and subclinical melioidosis.

Authors:  L R Ashdown; R W Johnson; J M Koehler; C A Cooney
Journal:  J Infect Dis       Date:  1989-08       Impact factor: 5.226

10.  DIFFERENTIATION OF EXOTOXIN AND OTHER BIOLOGICALLY ACTIVE SUBSTANCES IN PSEUDOMONAS PSEUDOMALLEI FILTRATES.

Authors:  R J HECKLY
Journal:  J Bacteriol       Date:  1964-12       Impact factor: 3.490
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