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Literature DB >> 24424453

IL-17: a key player in the P. acnes inflammatory cascade?

Diane M Thiboutot¹, Alison M Layton², E Anne Eady².

Abstract

Recent advances in our understanding of inflammatory skin diseases now afford an opportunity to delve deeper into microbial/host interactions in acne. Agak et al. report that Propionibacterium acnes induces IL-17 expression in peripheral blood mononuclear cells and present new evidence that IL-17+ cells are found in the perifollicular infiltrate of comedones. Additional studies are needed to assess the clinical relevance of IL-17 in acne.

Entities: Disease Species

Mesh：

Substances：

Year: 2014 PMID： 24424453 DOI： 10.1038/jid.2013.400

Source DB: PubMed Journal: J Invest Dermatol ISSN： 0022-202X Impact factor: 8.551

18 in total

1. Propionibacterium acnes and lipopolysaccharide induce the expression of antimicrobial peptides and proinflammatory cytokines/chemokines in human sebocytes.

Authors: István Nagy; Andor Pivarcsi; Kornélia Kis; Andrea Koreck; László Bodai; Andrew McDowell; Holger Seltmann; Sheila Patrick; Christos C Zouboulis; Lajos Kemény
Journal: Microbes Infect Date: 2006-05-19 Impact factor: 2.700

2. Cutting edge: all-trans retinoic acid down-regulates TLR2 expression and function.

Authors: Philip T Liu; Stephan R Krutzik; Jenny Kim; Robert L Modlin
Journal: J Immunol Date: 2005-03-01 Impact factor: 5.422

3. The microbial colonization of inflamed acne vulgaris lesions.

Authors: J P Leeming; K T Holland; W J Cuncliffe
Journal: Br J Dermatol Date: 1988-02 Impact factor: 9.302

4. Inflammation and extracellular matrix degradation mediated by activated transcription factors nuclear factor-kappaB and activator protein-1 in inflammatory acne lesions in vivo.

Authors: Sewon Kang; Soyun Cho; Jin Ho Chung; Craig Hammerberg; Gary J Fisher; John J Voorhees
Journal: Am J Pathol Date: 2005-06 Impact factor: 4.307

5. Activation of toll-like receptor 2 in acne triggers inflammatory cytokine responses.

Authors: Jenny Kim; Maria-Teresa Ochoa; Stephan R Krutzik; Osamu Takeuchi; Satoshi Uematsu; Annaliza J Legaspi; Hans D Brightbill; Diana Holland; William J Cunliffe; Shizuo Akira; Peter A Sieling; Paul J Godowski; Robert L Modlin
Journal: J Immunol Date: 2002-08-01 Impact factor: 5.422

6. Pro-inflammatory levels of interleukin-1 alpha-like bioactivity are present in the majority of open comedones in acne vulgaris.

Authors: E Ingham; E A Eady; C E Goodwin; J H Cove; W J Cunliffe
Journal: J Invest Dermatol Date: 1992-06 Impact factor: 8.551

7. Systemic isotretinoin therapy normalizes exaggerated TLR-2-mediated innate immune responses in acne patients.

Authors: Melanie C Dispenza; Ellen B Wolpert; Kathryn L Gilliland; Jenny P Dai; Zhaoyuan Cong; Amanda M Nelson; Diane M Thiboutot
Journal: J Invest Dermatol Date: 2012-04-19 Impact factor: 8.551

8. Protease-activated receptor-2 mediates the expression of inflammatory cytokines, antimicrobial peptides, and matrix metalloproteinases in keratinocytes in response to Propionibacterium acnes.

Authors: Sang Eun Lee; Ji-Min Kim; Se Kyoo Jeong; Jeong Eun Jeon; Hyun-Ju Yoon; Min-Kyung Jeong; Seung Hun Lee
Journal: Arch Dermatol Res Date: 2010-08-10 Impact factor: 3.017

9. Propionibacterium acnes Induces IL-1β secretion via the NLRP3 inflammasome in human monocytes.

Authors: Min Qin; Aslan Pirouz; Myung-Hwa Kim; Stephan R Krutzik; Hermes J Garbán; Jenny Kim
Journal: J Invest Dermatol Date: 2013-07-24 Impact factor: 8.551

10. Propionibacterium acnes Induces an IL-17 Response in Acne Vulgaris that Is Regulated by Vitamin A and Vitamin D.

Authors: George W Agak; Min Qin; Jennifer Nobe; Myung-Hwa Kim; Stephan R Krutzik; Grogan R Tristan; David Elashoff; Hermes J Garbán; Jenny Kim
Journal: J Invest Dermatol Date: 2013-08-07 Impact factor: 8.551

8 in total

1. Altered Gene Expression in Acne Vulgaris Patients Treated by Oral Isotretinoin: A Preliminary Study.

Authors: Yue Zheng; Wei Lai; Yuchen Jiang; Haiyan Chen; Le Han; Xiaoyuan Xie
Journal: Pharmgenomics Pers Med Date: 2020-09-15

2. Phenotype and Antimicrobial Activity of Th17 Cells Induced by Propionibacterium acnes Strains Associated with Healthy and Acne Skin.

Authors: George W Agak; Stephanie Kao; Kelsey Ouyang; Min Qin; David Moon; Ahsan Butt; Jenny Kim
Journal: J Invest Dermatol Date: 2017-08-31 Impact factor: 8.551

3. Serum 25-hydroxy vitamin D levels in patients with acne vulgaris and its association with disease severity.

Authors: Parviz Toossi; Zahra Azizian; Hassan Yavari; Tannaz Hoseinzade Fakhim; Seyed Hadi Sadat Amini; Ramin Enamzade
Journal: Clin Cases Miner Bone Metab Date: 2015-12-29

4. IL-17/Th17 pathway is activated in acne lesions.

Authors: Hanna-Leena Kelhälä; Riitta Palatsi; Nanna Fyhrquist; Sari Lehtimäki; Juha P Väyrynen; Matti Kallioinen; Minna E Kubin; Dario Greco; Kaisa Tasanen; Harri Alenius; Beatrice Bertino; Isabelle Carlavan; Bruno Mehul; Sophie Déret; Pascale Reiniche; Philippe Martel; Carine Marty; Ulrike Blume-Peytavi; Johannes J Voegel; Antti Lauerma
Journal: PLoS One Date: 2014-08-25 Impact factor: 3.240