Yeon-Ah Sung1, Jee-Young Oh1, Hyewon Chung2, Hyejin Lee3. 1. Department of Internal Medicine, Ewha Womans University School of Medicine, Seoul, South Korea. 2. Department of Obstetrics and Gynecology, Ewha Womans University School of Medicine, Seoul, South Korea. 3. Department of Internal Medicine, Ewha Womans University School of Medicine, Seoul, South Korea. Electronic address: hyejinlee@ewha.ac.kr.
Abstract
OBJECTIVE: To determine the features of polycystic ovary syndrome (PCOS) that are implicated in the associated reproductive and metabolic morbidities. DESIGN: Cross-sectional case-control study. SETTING: Academic medical setting. PATIENT(S): A total of 1,062 women with PCOS and 1,887 women without PCOS. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Physical examination including hirsutism scoring, biochemical and hormone measurements, ovarian ultrasound, and a 75-g oral glucose tolerance test to measure glucose and insulin levels. RESULT(S): A factor analysis identified four dominant factors in women with PCOS. These factors were interpreted as follows: [1] metabolic and hyperandrogenemia factor, [2] oligomenorrhea and hyperandrogenemia factor, [3] blood pressure factor, and [4] ovarian morphology factor. In women with PCOS, hyperandrogenemia was a significant predictor of metabolic syndrome after adjusting for age, body mass index, and insulin resistance in the regression analysis. CONCLUSION(S): A factor analysis identified multiple factors that are responsible for the abnormalities associated with PCOS. Hyperandrogenemia was a common underlying feature of the metabolic and reproductive abnormalities in women with PCOS but not in women without PCOS.
OBJECTIVE: To determine the features of polycystic ovary syndrome (PCOS) that are implicated in the associated reproductive and metabolic morbidities. DESIGN: Cross-sectional case-control study. SETTING: Academic medical setting. PATIENT(S): A total of 1,062 women with PCOS and 1,887 women without PCOS. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Physical examination including hirsutism scoring, biochemical and hormone measurements, ovarian ultrasound, and a 75-g oral glucose tolerance test to measure glucose and insulin levels. RESULT(S): A factor analysis identified four dominant factors in women with PCOS. These factors were interpreted as follows: [1] metabolic and hyperandrogenemia factor, [2] oligomenorrhea and hyperandrogenemia factor, [3] blood pressure factor, and [4] ovarian morphology factor. In women with PCOS, hyperandrogenemia was a significant predictor of metabolic syndrome after adjusting for age, body mass index, and insulin resistance in the regression analysis. CONCLUSION(S): A factor analysis identified multiple factors that are responsible for the abnormalities associated with PCOS. Hyperandrogenemia was a common underlying feature of the metabolic and reproductive abnormalities in women with PCOS but not in women without PCOS.
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