| Literature DB >> 24424134 |
Yufeng Wang1, Wu Yang2, Heather J Finlay2, Lalgudi S Harikrishnan2, Ji Jiang2, Muthoni G Kamau2, Katy Van Kirk2, David S Nirschl3, David S Taylor4, Alice Ye A Chen4, Xiaohong Yin4, Paul G Sleph4, Richard Z Yang4, Christine S Huang5, Leonard P Adam4, R Michael Lawrence2, Ruth R Wexler2, Mark E Salvati2.
Abstract
A series of diphenylpyridylethanamine-based inhibitors of cholesteryl ester transfer protein with aminoheterocycles appended onto the N-terminus of the chemotype were explored as urea mimetics. Potent compounds were discovered and were further optimized to improve metabolic stability and PXR transactivation profile.Entities:
Keywords: CETP
Mesh：
Substances：
Year: 2014 PMID： 24424134 DOI： 10.1016/j.bmcl.2013.12.088
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823