F Stelma1, M F Bhutta1. 1. MRC Harwell, Harwell Science and Innovation Campus, Didcot, UK.
Abstract
BACKGROUND: Hereditary sensorineural hearing loss is the most frequently occurring birth defect. It has profound effects for the individual and is a substantial burden on society. Insight into disease mechanisms can help to broaden therapeutic options and considerably lower lifetime social costs. In the past few decades, the identification of genes that can cause this type of hearing loss has developed rapidly. OBJECTIVE: This paper provides a concise overview of the currently known genes involved in non-syndromic hereditary hearing loss and their function in the inner ear.
BACKGROUND: Hereditary sensorineural hearing loss is the most frequently occurring birth defect. It has profound effects for the individual and is a substantial burden on society. Insight into disease mechanisms can help to broaden therapeutic options and considerably lower lifetime social costs. In the past few decades, the identification of genes that can cause this type of hearing loss has developed rapidly. OBJECTIVE: This paper provides a concise overview of the currently known genes involved in non-syndromic hereditary hearing loss and their function in the inner ear.
Authors: Rahul Mittal; Amit P Patel; Desiree Nguyen; Debbie R Pan; Vasanti M Jhaveri; Jason R Rudman; Arjuna Dharmaraja; Denise Yan; Yong Feng; Prem Chapagain; David J Lee; Susan H Blanton; Xue Zhong Liu Journal: Gene Date: 2018-01-10 Impact factor: 3.688
Authors: Hela Azaiez; Amanda R Decker; Kevin T Booth; Allen C Simpson; A Eliot Shearer; Patrick L M Huygen; Fengxiao Bu; Michael S Hildebrand; Paul T Ranum; Seiji B Shibata; Ann Turner; Yuzhou Zhang; William J Kimberling; Robert A Cornell; Richard J H Smith Journal: PLoS Genet Date: 2015-03-27 Impact factor: 5.917
Authors: Heiko Locher; John C M J de Groot; Liesbeth van Iperen; Margriet A Huisman; Johan H M Frijns; Susana M Chuva de Sousa Lopes Journal: Dev Neurobiol Date: 2015-02-28 Impact factor: 3.964