Greta Snellman1, Liisa Byberg, Eva Warensjö Lemming, Håkan Melhus, Rolf Gedeborg, Hans Mallmin, Alicja Wolk, Karl Michaëlsson. 1. Department of Surgical Sciences (G.S., L.B., E.W.L., K.M., H.Ma.), Section of Orthopedics; Department of Medical Sciences (H.Me.), Section of Clinical Pharmacology; and Department of Surgical Sciences (R.G.), Section of Anesthesiology and Intensive Care, Uppsala University, SE-751 85 Uppsala, Sweden; and Department of Nutritional Epidemiology (A.W.), Institute of Environmental Medicine, Karolinska Institutet, SE-171 77 Stockholm, Sweden.
Abstract
CONTEXT: The importance of dietary vitamin D for osteoporotic fracture prevention is uncertain. OBJECTIVE: Our objective was to investigate associations between dietary vitamin D intake with risk of fracture and osteoporosis. DESIGN AND PARTICIPANTS: In the population-based Swedish Mammography Cohort (including 61 433 women followed for 19 years), diet was assessed by repeated food frequency questionnaires. SETTING: The study was conducted in 2 municipalities in central Sweden. MAIN OUTCOME MEASURE: Incident fractures were identified from registry data. In a subcohort (n = 5022), bone mineral density was determined by dual-energy x-ray absorptiometry and serum 25-hydroxyvitamin D was measured using HPLC-tandem mass spectrometry. RESULTS: A total of 14 738 women experienced any type of first fracture during follow-up, and 3871 had a hip fracture. Multivariable-adjusted hazard ratio (HR) for any first fracture was 0.96 (95% confidence interval, 0.92-1.01) for the lowest (mean, 3.1 μg/d) and 1.02 (0.96-1.07) for the highest (mean, 6.9 μg/d) quintile compared with the third quintile of vitamin D intake. The corresponding HR for a first hip fracture was 1.02 (0.96-1.08) for the lowest and 1.14 (1.03-1.26) for the highest quintile. Intakes >10 μg/d, compared with <5 μg/d, conferred an HR of 1.02 (0.92-1.13) for any fracture and an HR of 1.27 (1.03-1.57) for hip fracture. The intake of vitamin D did not affect the odds for osteoporosis, although higher levels were associated with higher bone mineral density (0.3%-2%, P < .0001). A positive association was observed between vitamin D intake and serum 25-hydroxyvitamin D. CONCLUSIONS: Dietary intakes of vitamin D seem of minor importance for the occurrence of fractures and osteoporosis in community-dwelling Swedish women.
CONTEXT: The importance of dietary vitamin D for osteoporotic fracture prevention is uncertain. OBJECTIVE: Our objective was to investigate associations between dietary vitamin D intake with risk of fracture and osteoporosis. DESIGN AND PARTICIPANTS: In the population-based Swedish Mammography Cohort (including 61 433 women followed for 19 years), diet was assessed by repeated food frequency questionnaires. SETTING: The study was conducted in 2 municipalities in central Sweden. MAIN OUTCOME MEASURE: Incident fractures were identified from registry data. In a subcohort (n = 5022), bone mineral density was determined by dual-energy x-ray absorptiometry and serum 25-hydroxyvitamin D was measured using HPLC-tandem mass spectrometry. RESULTS: A total of 14 738 women experienced any type of first fracture during follow-up, and 3871 had a hip fracture. Multivariable-adjusted hazard ratio (HR) for any first fracture was 0.96 (95% confidence interval, 0.92-1.01) for the lowest (mean, 3.1 μg/d) and 1.02 (0.96-1.07) for the highest (mean, 6.9 μg/d) quintile compared with the third quintile of vitamin D intake. The corresponding HR for a first hip fracture was 1.02 (0.96-1.08) for the lowest and 1.14 (1.03-1.26) for the highest quintile. Intakes >10 μg/d, compared with <5 μg/d, conferred an HR of 1.02 (0.92-1.13) for any fracture and an HR of 1.27 (1.03-1.57) for hip fracture. The intake of vitamin D did not affect the odds for osteoporosis, although higher levels were associated with higher bone mineral density (0.3%-2%, P < .0001). A positive association was observed between vitamin D intake and serum 25-hydroxyvitamin D. CONCLUSIONS: Dietary intakes of vitamin D seem of minor importance for the occurrence of fractures and osteoporosis in community-dwelling Swedish women.
Authors: Ulrika Qundos; Kimi Drobin; Cecilia Mattsson; Mun-Gwan Hong; Ronald Sjöberg; Björn Forsström; David Solomon; Mathias Uhlén; Peter Nilsson; Karl Michaëlsson; Jochen M Schwenk Journal: Proteomics Clin Appl Date: 2015-04-21 Impact factor: 3.494
Authors: Yohannes Adama Melaku; Tiffany K Gill; Sarah L Appleton; Anne W Taylor; Robert Adams; Zumin Shi Journal: Nutrients Date: 2017-10-31 Impact factor: 5.717