Comparison of concurrent chemoradiotherapy followed by radical surgery and high-dose-rate intracavitary brachytherapy: a retrospective study of 240 patients with FIGO stage IIB cervical carcinoma.

BACKGROUND: The aim of this study was to compare the long-term survival outcome and late toxicity in patients with FIGO (International Federation of Gynecology and Obstetrics) stage IIB cervical carcinoma after two treatment modalities, ie, concurrent chemoradiotherapy followed by radical surgery and concurrent chemoradiotherapy followed by high-dose-rate intracavitary brachytherapy.
METHODS: Between November 2004 and November 2011, 240 patients with FIGO stage IIB cervical carcinoma were analyzed, comprising 119 patients treated with concurrent chemoradiotherapy followed by radical surgery (group 1) and 121 patients treated with concurrent chemoradiotherapy followed by high-dose-rate intracavitary brachytherapy (group 2). Local control, overall survival, progression-free survival, and treatment-related complications were compared between the two groups.
RESULTS: The median follow-up duration was 36 months. Concurrent chemoradiotherapy followed by radical surgery showed a survival benefit when comparing group 1 and group 2 (3-year overall survival, 94.9% versus 84.6%, P=0.011; 3-year progression-free survival, 91.0% versus 81.8%, P=0.049, respectively). Three-year local pelvic control was 94.6% in group 1 and 93.3% in group 2 (P=0.325). Prognostic factors in group 1 were: age (≤35 years versus >35 years), 3-year progression-free survival (74.1% versus 90.9%, P=0.037); tumor diameter (≥6 cm versus <6 cm); and 3-year progression-free survival, (60.6% versus 92.9%, P=0.004). Prognostic factors in group 2 were: tumor diameter (≥4 cm versus <4 cm); 3-year overall survival (78.0% versus 94.8%, P=0.043); tumor diameter (≥6 cm versus <6 cm); 3-year progression-free survival (42.9% versus 84.2%, P=0.032); and 3-year overall survival (42.9% versus 87.1%, P=0.013). Further, 50 patients (42.02%) in group 1 and 46 patients (38.02%) in group 2 suffered from late complications. Analysis of the difference in composition of late complications showed that the rate of leg edema was higher in group 1 (35.29% versus 4.96%, P=0.000) while the rate of radiation enteritis was higher in group 2 (30.58% versus 5.04%, P=0.000).
CONCLUSION: In patients with FIGO stage IIB cervical carcinoma, concurrent chemoradiotherapy followed by radical surgery achieved higher overall survival and progression-free survival rates in comparison with radical radiotherapy associated with concurrent chemotherapy. Tumor diameter could be a common prognostic factor in these two groups of patients.

Introduction

Concurrent cisplatin-based chemoradiotherapy is the standard treatment for locally advanced cervical carcinoma (LACC) based on five clinical trials (GOG85, Radiation Therapy Oncology Group [RTOG] 9001, GOG123, GOG120, SWOG 8797) and two meta-analyses.1,2 However, the 5-year survival of patients with LACC is still around 70%.3 In the GOG123 trial, survival status after concurrent chemoradiotherapy followed by radical surgery was better than after radiotherapy alone in patients with FIGO (International Federation of Gynecology and Obstetrics) stage IB2 cervical carcinoma, but for FIGO stage IIB, the large-scale international clinical experimental experience concerning surgical benefit is rare, especially in contrast with radical radiotherapy. Neoadjuvant treatments followed by radical surgery have been proposed, with data for overall survival and disease-free survival reported as ranging from 57% to 85% and from 64% to 90%, respectively.4,5 More recently, there have been reports that adjuvant surgery after chemoradiotherapy may represent a more effective strategy by removing radiochemoresistant foci,6–8 so it is still necessary to investigate the surgical benefits in patients with LACC.

About 80% of new cervical carcinoma cases are diagnosed in developing countries,9 and although 72% of patients with FIGO stage IIB cervical carcinoma are treated with definitive radiotherapy according to the annual FIGO report, in most high-risk areas of Asia, the majority of these patients undergo radical hysterectomy. For example, 62.7% of such patients have been reported to receive surgery-based therapy in Japan.10–12 It is becoming increasingly important to compare the benefit of surgery in patients with FIGO stage IIB cervical carcinoma, especially in high-risk Southeast Asia, with the disease reduction achieved in European countries and in the US.

In this paper, we report the results of a comparison between concurrent chemoradiotherapy followed by radical surgery and concurrent chemoradiotherapy followed by high-dose-rate intracavitary brachytherapy in 240 patients with FIGO stage IIB cervical carcinoma in high-risk regions of the People’s Republic of China. Long-term survival and late toxicity were observed, and some prognostic factors are identified.

Materials and methods

Selection criteria

From November 2004 to November 2011, 240 patients with FIGO stage IIB cervical carcinoma were treated at the Department of Radiation Oncology, Xijing Hospital, Fourth Military Medical University, People’s Republic of China. All patients had a Karnofsky performance status ≥70 and had no history of other malignancy or treatment for carcinoma. Pretreatment evaluations comprised the patient’s medical history, a blood count, liver and renal function tests, a gynecologic examination, cervical biopsy, chest X-ray, transvaginal ultrasound, abdominal ultrasonography, and pelvic magnetic resonance imaging (MRI). Tumor sizes were basically determined by MRI imaging. Patients had to have adequate bone marrow, hepatic, and renal function with the following criteria: a leukocyte count ≥3,000/mm3, a platelet count ≥100,000/mm3, hemoglobin ≥10 g/dL, total bilirubin ≤1.5 mg/dL, aspartate aminotransferase/alanine aminotransferase no more than twice the upper limit of normal, and serum creatinine ≤1.5 mg/dL.

Treatment modalities

Concurrent chemoradiotherapy

Pelvic external beam radiotherapy (EBRT) was delivered using three-dimensional conformal radiation techniques and 6 mV or 15 mV photons using a linear accelerator, ie, a Varian 23EX (Varian Medical Systems, Palo Alto, CA, USA) or a 600 C/D (Varian Medical Systems). Patients were immobilized on a custom vacuum mattress in the supine position and underwent a computed tomography simulation scan using a PQS and an AcQSim (Philips Health Care, Andover, MA, USA) with intravenous contrast and a 5 mm slice thickness. The clinical target volume included the gross tumor, cervix, uterus, parametrium, upper part of the vagina to 3 cm below the tumor invasion (according to the T2 MRI image), and regional lymph nodes (common, external, internal iliac, obturator, and presacral). Positive lymph nodes were delineated as having a minimum diameter ≥1 cm, being necrotic, or involving multiple lymph nodes. The planning target volume was defined by uniform three-dimensional expansion around the clinical target volume, using 7 mm margins around the lymph nodes, 10 mm around the vagina and parametrium, and 15 mm around the cervix and gross disease. Treatment was designed and computed using the PLATO system version 2.7.5. The EBRT dose was 40–50 Gy in 20–25 fractions. Radiotherapy was withheld when hematologic toxicity reached grade 4 or nonhematologic toxicity reached grade 3–4. Radiotherapy was resumed when hematologic and nonhematologic toxicity recovered to grade 2.

Concurrent chemotherapy was administered in 4–6 cycles by an intravenous infusion of weekly cisplatin (40 mg/m2) during pelvic EBRT. Chemotherapy was withheld under the following conditions: white blood cell count <2.0 × 109/L, absolute neutrophil count <1.0 × 109/L, platelet count <50 × 109/L, or grade 3–4 radiation enteritis or cystitis.

All 240 patients had a good response to standard treatment, with a decrease in tumor volume of at least 50% according to MRI on completion of concurrent chemoradiotherapy. The patients were divided into two groups, ie, for radical surgery or for high-dose-rate intracavitary brachytherapy. The choice of therapeutic modality depended mainly on patient preference, except in those who could not undergo surgery because of severe cardiac or pulmonary disease. Three such patients received intracavitary brachytherapy because of comorbidity, comprising two with a history of arrhythmia and one older patient (aged 71 years) with a permanent cardiac pacemaker.

Concurrent chemoradiotherapy followed by radical surgery (group 1)

Group 1 patients (n=119) underwent radical abdominal hysterectomy and pelvic lymphadenectomy. The interval between preoperative concurrent chemoradiotherapy and radical surgery was 2–3 weeks. The resected primary and lymph node specimens were processed into sections for hematoxylin and eosin staining and pathologic observation. The pathologic response to neoadjuvant therapy was evaluated based on histopathologic examination of the resected specimens, ie, uterus, vaginal cuff, parametrium, and pelvic lymph nodes.

Radical radiotherapy associated with concurrent chemotherapy (group 2)

Group 2 patients (n=121) underwent radical radiotherapy. The whole pelvic EBRT dose was boosted to 50 Gy in 25 fractions, and positive lymph nodes were boosted to 64–66 Gy. Computed tomography-based image-guided brachytherapy was applied at the conclusion of pelvic EBRT, and concurrently with boost radiation to the lymph nodes. An Ir-192 source was used for high-dose-rate intracavitary brachytherapy. High-dose-rate intracavitary brachytherapy was delivered with 28–35 Gy in 4–5 fractions to 90% of the high-risk clinical target volume (D90), using interstitial implantation or an intracavity applicator (microSelectron-HDR Ir-192 set or Fletcher applicator set, Nucletron, Veenendaal, The Netherlands). The treatment procedure for patients in group 1 and group 2 is shown schematically in Figure 1.

Figure 1

Schematic diagram showing treatment procedure for 240 patients in group 1 and group 2.

Abbreviations: EBRT, external beam radiotherapy; HDR-ICBT, high-dose-rate intracavitary brachytherapy.

Follow-up

Patients were followed up at 3-monthly intervals in the first year and at 6-monthly intervals thereafter with regular gynecologic examination, laboratory studies (blood count, liver and renal function tests), transvaginal ultrasound, abdominal ultrasonography, superficial lymph node examination, and radiographic studies, including chest computed tomography and/or pelvic MRI.

Toxicity assessment was performed according to the RTOG/European Organization for Research and Treatment for Carcinoma late radiation morbidity scoring scheme.13 Surgical complications were classified using the Chassagne grading system.14,15 Overall survival and progression-free survival rates were calculated from the date of surgery or completion of intracavitary brachytherapy to the last follow-up date.

Statistical analysis

Statistical analysis was performed using Statistical Package for the Social Sciences version 17 software (SPSS Inc, Chicago, IL, USA). Overall survival and progression-free survival rates were computed by the Kaplan–Meier method and are shown. Differences in the survival curves were estimated using the log-rank test. Multivariate analysis was performed by linear logistic regression. Other estimations were performed using the chi-square test. P-values less than 0.05 were considered to be statistically significant.

Results

Patient characteristics

The median follow-up is 36 (range 2–75) months. There are 118 patients with a follow-up period of more than 3 years (61 patients in group 1 and 57 patients in group 2). The median age is 45 (range 25–71) years. One hundred and nineteen patients received concurrent chemoradiotherapy followed by radical surgery in group 1, and 121 patients received radical radiotherapy with concurrent chemotherapy (weekly cisplatin 40 mg/m2) in group 2. Of note, none of the patients in group 1 accepted postoperative adjuvant therapy. An overall treatment time of more than 56 days has been correlated with a bad prognosis. All patients in group 1 completed their full treatment in 56 days. However, in group 2, overall treatment time ranged from 45 to 99 days, with a median of 60 days. No patient had an extension of overall treatment time because of severe toxicity. The main reason for extension of overall treatment time in group 2 was socioeconomic problems. Patient characteristics are shown in Table 1.

Table 1

Patient characteristics

Characteristics	Group 1 (n=119)	Group 2 (n=121)	χ2	P-value
	Patients, n (%)	Patients, n (%)
Median age (range, years)	45, 27–65	52, 25–71
>35	110 (92.44%)	117 (96.69%)	2.122	0.165
≤35	9 (7.56%)	4 (3.31%)
KPS score
90	46 (38.66%)	42 (34.71%)	0.402	0.592
80	66 (55.46%)	73 (60.33%)	0.583	0.513
70	7 (5.88%)	6 (4.96%)	0.100	0.783
Tumor diameter (cm) (range, median, mean)	1.2–8.0, 4.5, 4.43	1.5–6.5, 4.0, 3.88
≥4 cm	93 (78.15%)	74 (61.16%)	8.187	0.005**
<4 cm	26 (21.85%)	47 (38.84%)
≥6 cm	11 (9.24%)	7 (5.79%)	1.034	0.337
<6 cm	108 (90.76%)	114 (94.21%)
Pathologic types
SCC	112 (94.12%)	116 (95.87%)	0.387	0.569
non-SCC	7 (5.88%)	5 (4.13%)
LN involvement
+	13 (10.92%)	24 (19.83%)	3.653	0.073
−	106 (89.08%)	97 (80.17%)
EBRT dose
40–45 Gy	39	28	2.766	0.114
46–50 Gy	80	93
Median follow-up (range, months)	36, 7–75	30, 2–70		0.173

Abbreviations: EBRT, external beam radiotherapy; KPS, Karnofsky performance status; SCC, squamous cell carcinoma; LN, lymph node. ** P<0.01.

Survival outcomes

Concurrent chemoradiotherapy followed by radical surgery in group 1 showed a survival benefit compared with group 2 (3-year overall survival 94.9% versus 84.6%, P=0.011; 3-year progression-free survival 91.0% versus 81.8%, P=0.049) (Figure 2). Three-year local pelvic control was 94.6% in group 1 and 93.3% in group 2, respectively (P=0.325).

Figure 2

Overall survival and progression-free survival in group 1 and group 2 patients, respectively. Patients in group 1 show a survival benefit in comparison with those in group 2. Three-year overall survival in group 1 was 94.9% and in group 2 was 84.6% (*P=0.011). Three-year progression-free survival in group 1 was 91.0% and in group 2 was 81.8% (* P=0.049).

Abbreviations: OS, overall survival; PFS, progression-free survival; CCRT, concurrent chemoradiotherapy; ICBT, intracavitary brachytherapy.

In group 1, local regional failure developed in five patients (4.20%). Distant metastasis developed in seven patients (5.88%). One patient developed pelvic recurrence and liver metastasis concurrently. One patient in group 1 developed postoperative intestinal obstruction. In group 2, local regional failure developed in eight patients (6.61%) and distant metastasis developed in 13 patients (10.74%). Of note, one patient died from a second primary tumor (leukemia) in group 2. Distant metastasis was still the main reason for treatment failure in these two groups. No patients died from non-tumor-related diseases or reasons. Treatment failure patterns in the two groups are summarized in Table 2.

Table 2

Treatment failure patterns in group 1 and group 2 patients

	Group 1 (n=119)	Group 2 (n=121)	χ2	P-value
	Patients, n (%)	Patients, n (%)
Pelvic recurrence	5 (4.20%)	8 (6.61%)	0.680	0.570
Total distant metastasis	7 (5.88%)	13 (10.74%)	1.856	0.243
Lung metastasis	3 (2.52%)	6 (4.96%)
Bone metastasis	1 (0.84%)	4 (3.31%)
Lymph node metastasis	2 (1.68%)	4 (3.31%)
Liver metastasis	1 (0.84%)	0
Second primary tumor	0	1 (0.83%)	0.988	1.000
Total treatment failure	11* (9.24%)	22# (18.18%)	4.042	0.060

Notes: no patient has died for non-tumor-related reasons.

One case suffered from pelvic recurrence and liver metastasis concurrently in group 1

One case suffered from bone metastasis and lymph node metastasis concurrently in group 2.

Tumor size as a key prognostic factor

Prognostic factors in group 1 were: age (≤35 years versus >35 years); 3-year progression-free survival (71.4% versus 90.9%, P=0.037); tumor diameter (≥6 cm versus <6 cm); and 3-year progression-free survival (60.6% versus 92.9%, P=0.004). Prognostic factors in group 2 were: tumor diameter (≥4 cm versus <4 cm); 3-year overall survival (78.0% versus 94.8%, P=0.043); tumor diameter (≥6 cm versus <6 cm); 3-year progression-free survival (42.9% versus 84.2%, P=0.032); and 3-year overall survival (42.9% versus 87.1%, P=0.013). These data are shown in Tables 3, 4 and Figure 3.

Table 3

Correlations between clinical/pathologic factors and survival outcome in group 1

Prognostic factors	Patients, n	3-year OS	P-value	Exp (B) HR	95% CI		3-year PFS	P-value	Exp (B) HR	95% CI
					Lower	Upper				Lower	Upper
Age
≤35 years	9	88.9%	0.258	0.278	0.030	2.552	74.1%	0.037*	0.167	0.031	0.894
>35 years	110	95.4%					90.9%
Primary tumor
<4 cm	26	96.2%	0.797	1.353	0.135	13.562	96.0%	0.653	1.468	0.275	7.844
≥4 cm	93	94.6%					87.8%
Primary tumor
<6 cm	108	96.3%	0.122	0.232	0.038	1.405	92.9%	0.004**	0.140	0.036	0.542
≥6 cm	11	81.8%					60.6%
EBRT dose
40–45 Gy	39	87.5%	0.961	0.000	0.000	3.030	87.1%	0.432	0.415	0.046	3.725
46–50 Gy	80	96.6%					93.3%
LN involvement
+	13	92.3%	0.145	0.296	0.057	1.524	80.8%	0.422	0.536	0.117	2.455
−	106	95.2%					90.4%

Abbreviations: CI, confidence interval; HR, hazard ratio; SCC, squamous cell carcinoma; EBRT, external beam radiotherapy; LN, lymph node; OS, overall survival; PFS, progression-free survival * P<0.05; ** P<0.01.

Table 4

Correlations between clinical/pathologic factors and survival outcome in group 2

Prognostic factors	Patients, n	3-year OS	P-value	Exp (B) HR	95% CI		3-year PFS	P-value	Exp (B) HR	95% CI
					Lower	Upper				Lower	Upper
Age
≤35 years	4	75.0%	0.590	1.849	0.198	17.265	75.0%	0.619	1.745	0.195	15.648
>35 years	117	84.9%					82.0%
Primary tumor
<4 cm	47	94.8%	0.043*	0.211	0.047	0.949	89.4%	0.127	0.444	0.157	1.258
≥4 cm	74	78.0%					77.0%
Primary tumor
<6 cm	114	87.1%	0.013*	0.179	0.046	0.700	84.2%	0.032*	0.226	0.058	0.882
≥6 cm	7	42.9%					42.9%
OTT
≥56 days	44	83.1%	0.347	0.602	0.201	1.732	79.2%	0.202	0.523	0.193	1.416
<56 days	77	86.4%					86.2%
LN involvement
+	24	86.4%	0.700	1.276	0.369	4.409	80.3%	0.431	1.632	0.483	5.515
−	97	87.5%					84.2%

Abbreviations: CI, confidence interval; HR, hazard ratio; SCC, squamous cell carcinoma; OTT, overall treatment time; LN, lymph node; OS, overall survival; OTT, overall treatment time; PFS, progression-free survival *P<0.05.

Figure 3

Overall survival and progression-free survival are shown regarding tumor size as a prognostic factor with a boundary of 6 cm in group 1 (A and B) (3-year overall survival, P=0.122; 3-year progression-free survival, P=0.004) and with a boundary of 4 cm in group 2 (C and D) (3-year overall survival, P=0.043; 3-year progression-free survival, P=0.127).

Abbreviations: OS, overall survival; PFS, progression-free survival.

Postoperative pathologic response in group 1

Pathologic responses to neoadjuvant therapy were further evaluated in group 1 based on histopathologic examination. The postoperative pathologic response included complete response, partial response, and residual carcinoma. Complete response was defined as complete disappearance of all macroscopic and microscopic disease; partial response as presence of persistent atypical cells or cervical intraepithelial neoplasia; and residual carcinoma as macroscopic and/or microscopic residual disease. The complete response rate was 27.73% (33/119), the partial response rate was 41.18% (49/119), and the residual carcinoma rate was 31.09% (37/119). The total effective pathologic alleviation rate was 68.91%, including complete responses (33/119, 27.73%) and partial responses (49/119, 41.18%).

Late toxicity

Fifty patients (50/119, 42.02%) in group 1 and 46 patients (46/121, 38.02%) in group 2 suffered late complications (Table 5). Of note, 12 patients in group 1 suffered from at least two types of complications concurrently, and eight patients in group 2 suffered from at least two types of complications concurrently. There was no statistically significant difference in total late complication rate between the two groups, but the composition showed obvious differences. The rate of leg edema in group 1 was higher than in group 2 (35.29% versus 4.96%, P=0.000), and the radiation enteritis rate in group 2 was higher than in group 1 (30.58% versus5.04%, P=0.000). The data indicate that radiation enteritis was more common in group 2 and might be correlated with intracavitary brachytherapy and boost radiation to the lymph nodes. The median number of lymph node dissections was 18 (range 6–42) in group 1, and after subgroup analysis, the data showed that leg edema occurred more frequently when pelvic lymph node dissection was ≥20 (55.56% versus 29.79%, P=0.022).

Table 5

Late complications in group 1 and group 2 patients

Late complication	Group 1 (n=119)	Group 2 (n=121)	χ2	P-value
	Patients, n (%)	Patients, n (%)
Irradiation enteritis	6 (5.04%)	37 (30.58%)	26.603	0.000**
Grade 1	6	23
Grade 2	0	14
Irradiation cystitis	10 (8.40%)	10 (8.26%)	0.002	1.000
Grade 1	10	7
Grade 2	–	3
Leg edema	42 (35.29%)	6 (4.96%)	34.507	0.000**
Grade 1	32	4
Grade 2	10	2
Uronephrosis	5 (4.20%)	1 (0.83%)	2.804	0.118
Thrombus	3 (2.52%)	0	3.089	0.120
Intestinal obstruction	1 (0.84%)	0	1.021	0.496

Note:

P<0.01.

Discussion

The treatment strategy used for LACC has changed over the past two decades. Combined treatment modalities have focused on radical radiotherapy associated with concurrent chemotherapy, preoperative concurrent chemoradiotherapy with completion surgery, and neoadjuvant chemotherapy followed by completion surgery in recent years.16–20 According to the FIGO annual report of 2003, 72% of patients with FIGO stage IIB cervical carcinoma were treated with definitive radiotherapy.12 In contrast, surgery is preferentially utilized over radiotherapy in most high-risk Southeast Asian areas, so it is still important to explore the surgical benefit for LACC patients. In this retrospective study, we used patients who underwent radical radiotherapy associated with concurrent chemotherapy as the historical concurrent control group. Concurrent chemoradiotherapy followed by radical surgery showed a survival benefit in patients with FIGO stage IIB cervical carcinoma.

Both radical radiotherapy and surgery can destroy malignant cervical and paracervical cells as well as regional lymph nodes. However, surgery is recommended in several reports because it can remove chemoradiotherapy-resistant foci.7,21,22 For example, Houvenaeghel et al22 reported on 30 patients with advanced cervical carcinoma and bulky residual disease (≥2 cm) after concurrent chemoradiotherapy who accepted curative surgery. In the absence of para-aortic involvement, 80% of these patients were still alive 5 years after curative surgery. This result suggests that adjuvant surgery might improve the outcome of patients with bulky residual disease after concurrent chemoradiotherapy. Lèguevaque et al18 reported that additional surgery after concurrent chemoradiotherapy followed by brachytherapy improved disease-free survival by reducing pelvic recurrence. In their study, disease-free survival and overall survival were compared in 111 patients with FIGO stage IB1 to IVA disease (mainly FIGO stage IIB [55/111, 49.5%]). The recurrence rate was lower in patients who underwent completion surgery with less than 50% residual tumor than in patients with a good response to concurrent chemoradiotherapy who were therefore treated conservatively (22.4% versus 36.4%, P=0.01). This research suggests that surgery could have a survival benefit for patients who do not have a good response to concurrent chemoradiotherapy by removing chemoradiotherapy-resistant foci.

Pelvic recurrence and distant metastasis could be decreased as a consequence of removal of chemoradiotherapy-resistant foci. Carcopino et al23 reported on the survival outcome in patients with FIGO stage IB–IVA cervical carcinoma who underwent surgery after concurrent chemoradiotherapy. Surgery was curative in 127 cases and pelvic control was achieved in 114 cases. Pelvic control and survival rates were equivalent in patients with stage IB–II and III–IVA disease, suggesting that adjuvant surgery following chemoradiotherapy may improve local control, enabling patients with stage III–IVA disease to have a survival outcome comparable with that of patients with stage IB–II disease. In our study, surgical-based treatment (group 1) also achieved better pelvic control and an improved survival outcome, and this result is consistent with the other published research. For example, Kato et al24 reported a multi-institutional Phase II clinical study from East and Southeast Asia in which 120 patients with LACC (60 with bulky stage IIB disease) accepted concurrent chemoradiotherapy using five cycles of weekly cisplatin. Radiotherapy consisted of pelvic EBRT (total dose 50 Gy) and intracavitary brachytherapy. This treatment modality was similar to that used for group 2 in our study. In that Phase II clinical study, the 2-year pelvic tumor control rate for patients with bulky stage IIB disease was 94.2%. In our study, the 2-year pelvic tumor control rate in group 2 (93.3%) was comparable with that in the report by Kato et al (94.2%).

Distant metastasis is still the main reason for treatment failure. Recent research suggests that local pelvic failure is associated with a higher risk of metastasis. In our study, distant metastasis occurred more frequently in group 2 (13/121, 10.74%) than in group 1 (7/119, 5.88%). We therefore deduced that radical surgery could decrease the risk of metastasis by clearing the pelvic lymph nodes, and could also bring about a survival benefit by removal of radiochemotherapy-resistant foci, thereby improving pelvic control in patients with FIGO stage IIB cervical carcinoma.

Size of the primary tumor is an independent risk factor for local regional failure and survival according to multivariate analysis.25 In a previous study, we showed that preoperative concurrent chemoradiotherapy can improve progression-free survival and overall survival compared with radiotherapy alone when the tumor diameter is less than 5 cm, indicating that the beneficial effect of concurrent chemotherapy might be limited or depend on tumor size.26 In the present work, the size of the primary tumor was still an independent risk factor in group 1 patients with a boundary of 6 cm and those in group 2 with a boundary of 4 cm. The mean tumor diameter in group 1 (4.43 cm) was larger than that in group 2 (3.88 cm), and the difference in tumor size between these two groups was statistically significant for a boundary of 4 cm (P=0.005), but the survival outcome was better in group 1. This result implies that surgical treatment could alleviate the adverse prognostic effect of primary tumor burden. Based on this difference, we deduced that radical surgery could bring about a survival benefit for patients with a bulky tumor burden by removing radiochemotherapy-resistant foci, which is consistent with other published research,18 but this conclusion needs to be validated in a large number of patients.

The use of a three-modality treatment can achieve survival outcomes compared with those achieved by exclusive use of chemoradiotherapy. However, one of the concerns about surgery following chemoradiotherapy is surgical morbidity. Tummers et al21 reported on the outcome of surgery after chemoradiotherapy (with intensity-modulated arc therapy) in 34 patients with LACC, and their complication rates are comparable with those of primary surgery for cervical carcinoma. In our study, the main complication in group 1 was leg edema, and the number of lymph node dissections (≥20) is related to the risk of leg edema. Further study should focus on how to decrease the rate of lymph node metastasis, with a view to determining the feasibility and safety of individualized surgical treatment. We do believe that a new concept of radical surgery based on intraoperative findings might decrease the risk of surgical complications.27 The main complication in group 2 was radiation enteritis (30.58% versus 5.04%, P=0.000). The patient distribution between group 1 and group 2 with regard to EBRT dose was not significantly different (Table 1, P=0.114), so it was deduced that the higher rate of radiation enteritis in group 2 might be related to intracavitary brachytherapy and boost radiation to the lymph nodes. Of 24 patients in group 2 who accepted boost radiation to the lymph nodes, seven (29.2%) developed enteritis.

Overall treatment time is potentially a poor prognostic factor, with a boundary of 56 days for cervical carcinoma. All patients in group 1 received their full treatment in 56 days, with longer treatment courses occurring mainly in group 2 (median 60 days; range 45–99 days). According to research reported by Huang et al, tumor repopulation is indeed a problem.28 Accelerated tumor repopulation has significant implications in low-dose-rate brachytherapy, and dose escalation may be required to compensate for the effects of tumor repopulation if the course of radiation therapy is protracted. In our study, patients in group 2 accepted high-dose-rate but not low-dose-rate intracavitary brachytherapy after EBRT. On the other hand, EBRT dose compensation (0.6 Gy/day) was given to patients with a long EBRT treatment course.

The survival outcome did not show a statistically significant difference with regard to overall treatment time (≥56 days versus <56 days) in group 2. Considering the fact that the median follow-up has been relatively short (36 months), we shall continue our observations to validate this conclusion by extension of follow-up.

In conclusion, this study has shown that concurrent chemoradiotherapy followed by radical surgery could lead to a better survival outcome in comparison with that achieved by radical radiotherapy with weekly cisplatin in 240 patients with FIGO stage IIB cervical carcinoma. Late complications were acceptable and comparable between the two treatment groups. Tumor diameter might also represent a prognostic factor for these patients. In view of the weakness of any conclusion based on a single institution and retrospective experience, we plan to perform a randomized multicenter prospective study in a greater population of subjects to validate our conclusion.