Ligand-controlled E/Z selectivity and enantioselectivity in palladium-catalyzed allylation of benzofuranones with 1,2-disubstituted allylic carbonates.

The first highly E- and enantioselective allylic alkylation of prochiral carbon nucleophiles with 1,2-disubstituted allylic carbonates is reported. The key to the successful development of this protocol is the ability of modular ion-paired chiral ligands to simultaneously control the E/Z selectivity and enantioselectivity.