Literature DB >> 24418753

Expression and function of a novel isoform of Sox5 in malignant B cells.

Shanique K E Edwards1, Anand Desai2, Yan Liu2, Carissa R Moore2, Ping Xie3.   

Abstract

Using a mouse model with the tumor suppressor TRAF3 deleted from B cells, we identified Sox5 as a gene strikingly up-regulated in B lymphomas. Sox5 proteins were not detected in normal or premalignant TRAF3(-/-) B cells even after treatment with B cell stimuli. The Sox5 expressed in TRAF3(-/-) B lymphomas represents a novel isoform of Sox5, and was localized in the nucleus of malignant B cells. Overexpression of Sox5 inhibited cell cycle progression, and up-regulated the protein levels of p27 and β-catenin in human multiple myeloma cells. Together, our findings indicate that Sox5 regulates the proliferation of malignant B cells.
Copyright © 2013 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  B lymphoma; Multiple myeloma; Sox5; TRAF3; p27; β-Catenin

Mesh：

Substances：

Year:  2013        PMID： 24418753      PMCID： PMC3947564          DOI： 10.1016/j.leukres.2013.12.016

Source DB:  PubMed          Journal:  Leuk Res        ISSN： 0145-2126            Impact factor:   3.156


  52 in total

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Authors:  Chenguang Wang; Yanhong Tai; Michael P Lisanti; D Joshua Liao
Journal:  Cancer Biol Ther       Date:  2011-04-01       Impact factor: 4.742

2.  Clonal B cells in patients with hepatitis C virus-associated mixed cryoglobulinemia contain an expanded anergic CD21low B-cell subset.

Authors:  Edgar D Charles; Claudia Brunetti; Svetlana Marukian; Kimberly D Ritola; Andrew H Talal; Kristen Marks; Ira M Jacobson; Charles M Rice; Lynn B Dustin
Journal:  Blood       Date:  2011-03-18       Impact factor: 22.113

3.  Upregulation of the SOX5 by promoter swapping with the P2RY8 gene in primary splenic follicular lymphoma.

Authors:  C T Storlazzi; F Albano; C Lo Cunsolo; C Doglioni; M C Guastadisegni; L Impera; A Lonoce; S Funes; E Macrì; P Iuzzolino; I Panagopoulos; G Specchia; M Rocchi
Journal:  Leukemia       Date:  2007-06-07       Impact factor: 11.528

4.  Coamplification of DAD-R, SOX5, and EKI1 in human testicular seminomas, with specific overexpression of DAD-R, correlates with reduced levels of apoptosis and earlier clinical manifestation.

Authors:  Gaetano Zafarana; Ad J M Gillis; Ruud J H L M van Gurp; Per G Olsson; Fons Elstrodt; Hans Stoop; José Luis Millán; J Wolter Oosterhuis; Leendert H J Looijenga
Journal:  Cancer Res       Date:  2002-03-15       Impact factor: 12.701

Review 5.  Apoptotic signaling by c-MYC.

Authors:  B Hoffman; D A Liebermann
Journal:  Oncogene       Date:  2008-10-27       Impact factor: 9.867

6.  Transcriptional regulation of an axonemal central apparatus gene, sperm-associated antigen 6, by a SRY-related high mobility group transcription factor, S-SOX5.

Authors:  Elizabeth Anne Kiselak; Xuening Shen; Jingmei Song; David Roberto Gude; Jiannan Wang; Steven L Brody; Jerome F Strauss; Zhibing Zhang
Journal:  J Biol Chem       Date:  2010-07-28       Impact factor: 5.157

7.  SOX5 controls the sequential generation of distinct corticofugal neuron subtypes.

Authors:  Tina Lai; Denis Jabaudon; Bradley J Molyneaux; Eiman Azim; Paola Arlotta; Joao R L Menezes; Jeffrey D Macklis
Journal:  Neuron       Date:  2008-01-24       Impact factor: 17.173

8.  SoxD proteins influence multiple stages of oligodendrocyte development and modulate SoxE protein function.

Authors:  C Claus Stolt; Anita Schlierf; Petra Lommes; Simone Hillgärtner; Torsten Werner; Thomas Kosian; Elisabeth Sock; Nicoletta Kessaris; William D Richardson; Veronique Lefebvre; Michael Wegner
Journal:  Dev Cell       Date:  2006-11       Impact factor: 12.270

9.  The differentiation and stress response factor XBP-1 drives multiple myeloma pathogenesis.

Authors:  Daniel R Carrasco; Kumar Sukhdeo; Marina Protopopova; Raktim Sinha; Miriam Enos; Daniel E Carrasco; Mei Zheng; Mala Mani; Joel Henderson; Geraldine S Pinkus; Nikhil Munshi; James Horner; Elena V Ivanova; Alexei Protopopov; Kenneth C Anderson; Giovanni Tonon; Ronald A DePinho
Journal:  Cancer Cell       Date:  2007-04       Impact factor: 31.743

10.  Transcriptional regulation of chondrogenesis by coactivator Tip60 via chromatin association with Sox9 and Sox5.

Authors:  Takako Hattori; Francoise Coustry; Shelley Stephens; Heidi Eberspaecher; Masaharu Takigawa; Hideyo Yasuda; Benoit de Crombrugghe
Journal:  Nucleic Acids Res       Date:  2008-04-04       Impact factor: 16.971
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  10 in total

1.  SOX5 interacts with YAP1 to drive malignant potential of non-small cell lung cancer cells.

Authors:  Hongbo Zou; Shuang Wang; Songtao Wang; Hong Wu; Jing Yu; Qian Chen; Wei Cui; Ye Yuan; Xianmei Wen; Jian He; Lin Chen; Ruilian Yu; Ming Zhang; Haitao Lan; Guoxiang Jin; Xia Zhang; Xiuwu Bian; Chuan Xu
Journal:  Am J Cancer Res       Date:  2018-05-01       Impact factor: 6.166

Review 2.  TRAF3, ubiquitination, and B-lymphocyte regulation.

Authors:  Wai W Lin; Bruce S Hostager; Gail A Bishop
Journal:  Immunol Rev       Date:  2015-07       Impact factor: 12.988

3.  Pum2 and TDP-43 refine area-specific cytoarchitecture post-mitotically and modulate translation of Sox5, Bcl11b, and Rorb mRNAs in developing mouse neocortex.

Authors:  Melanie Richter; Nagammal Neelagandan; Kawssar Harb; Elia Magrinelli; Hend Harfoush; Katrin Kuechler; Melad Henis; Irm Hermanns-Borgmeyer; Froylan Calderon de Anda; Kent Duncan
Journal:  Elife       Date:  2022-03-09       Impact factor: 8.140

4.  Signaling mechanisms of bortezomib in TRAF3-deficient mouse B lymphoma and human multiple myeloma cells.

Authors:  Shanique K E Edwards; Yeming Han; Yingying Liu; Benjamin Z Kreider; Yan Liu; Sukhdeep Grewal; Anand Desai; Jacqueline Baron; Carissa R Moore; Chang Luo; Ping Xie
Journal:  Leuk Res       Date:  2015-12-19       Impact factor: 3.156

5.  Elevated Choline Kinase α-Mediated Choline Metabolism Supports the Prolonged Survival of TRAF3-Deficient B Lymphocytes.

Authors:  Samantha Gokhale; Wenyun Lu; Sining Zhu; Yingying Liu; Ronald P Hart; Joshua D Rabinowitz; Ping Xie
Journal:  J Immunol       Date:  2019-12-11       Impact factor: 5.422

6.  Targeting TRAF3 Downstream Signaling Pathways in B cell Neoplasms.

Authors:  Carissa R Moore; Shanique Ke Edwards; Ping Xie
Journal:  J Cancer Sci Ther       Date:  2015-02

7.  Integrated Analysis of Dysregulated miRNA-gene Expression in HMGA2-silenced Retinoblastoma Cells.

Authors:  Nalini Venkatesan; Pr Deepa; Madavan Vasudevan; Vikas Khetan; Ashwin M Reddy; Subramanian Krishnakumar
Journal:  Bioinform Biol Insights       Date:  2014-09-04

8.  Mitochondrial Fission Factor Is a Novel Interacting Protein of the Critical B Cell Survival Regulator TRAF3 in B Lymphocytes.

Authors:  Yingying Liu; Samantha Gokhale; Jaeyong Jung; Sining Zhu; Chang Luo; Debanjan Saha; Jessie Yanxiang Guo; Huaye Zhang; Saw Kyin; Wei-Xing Zong; Eileen White; Ping Xie
Journal:  Front Immunol       Date:  2021-10-20       Impact factor: 8.786

9.  High levels of SOX5 decrease proliferative capacity of human B cells, but permit plasmablast differentiation.

Authors:  Mirzokhid Rakhmanov; Heiko Sic; Anne-Kathrin Kienzler; Beate Fischer; Marta Rizzi; Maximilian Seidl; Kerstina Melkaoui; Susanne Unger; Luisa Moehle; Nadine E Schmit; Sachin D Deshmukh; Cemil Korcan Ayata; Wolfgang Schuh; Zhibing Zhang; François-Loic Cosset; Els Verhoeyen; Hans-Hartmut Peter; Reinhard E Voll; Ulrich Salzer; Hermann Eibel; Klaus Warnatz
Journal:  PLoS One       Date:  2014-06-19       Impact factor: 3.240

10.  Mutated in colorectal cancer (MCC) is a novel oncogene in B lymphocytes.

Authors:  Shanique K E Edwards; Jacqueline Baron; Carissa R Moore; Yan Liu; David H Perlman; Ronald P Hart; Ping Xie
Journal:  J Hematol Oncol       Date:  2014-09-09       Impact factor: 17.388
  10 in total

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