| Literature DB >> 24418655 |
Hua-Yi Jiang1, Wei-Guang Wang2, Min Zhou1, Hai-Yan Wu1, Rui Zhan2, Xiao-Nian Li2, Xue Du2, Yan Li2, Jian-Xin Pu3, Han-Dong Sun4.
Abstract
Phytochemical investigation of the aerial parts of Isodon sculponeatus afforded six new 7,20-epoxy-ent-kauranoids, sculponins U-Z (1-6), and 11 known diterpenoids (7-17). The structures of these new compounds were elucidated primarily by means of extensive spectroscopic analysis, and the absolute configuration of 1 was determined by single crystal X-ray diffraction. Compound 5 exhibited weak cytotoxic activity against HL-60, SMMC-7721, MCF-7, and SW-480 cell lines, and it also inhibited NO production in LPS-stimulated RAW264.7 cells, with IC50 value of 13.8 μM.Entities:
Keywords: Anti-inflammatory activity; Bisjaponin A (PubChem CID: 24895695); Cytotoxicity; Diterpenoids; Hebeiabinin B (PubChem CID: 16112773); Isodon sculponeatus; Lushanrubescensin J (PubChem CID: 11297111); Sculponeatin N (PubChem CID: 42643119); X-ray diffraction
Mesh：
Substances：
Year: 2014 PMID： 24418655 DOI： 10.1016/j.fitote.2013.12.025
Source DB: PubMed Journal: Fitoterapia ISSN： 0367-326X Impact factor: 2.882